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Effect of multi-strain probiotics (multi-strain microbial cell preparation) on glycemic control and other diabetes-related outcomes in people with type 2 diabetes: a randomized controlled trial

Aim: Evidence of a possible connection between gut microbiota and several physiological processes linked to type 2 diabetes is increasing. However, the effect of multi-strain probiotics in people with type 2 diabetes remains unclear. This study investigated the effect of multi-strain microbial cell...

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Main Authors: Firouzi, Somayyeh, Abdul Majid, Hazreen, Ismail, Amin, Kamaruddin, Nor Azmi, Mohd Yusof, Barakatun Nisak
Format: Article
Language:English
Published: Springer 2017
Online Access:http://psasir.upm.edu.my/id/eprint/56203/1/Effect%20of%20multi-strain%20probiotics%20%28multi-strain%20microbial%20cell%20preparation%29%20on%20glycemic%20control%20and%20other%20diabetes-related%20outcomes%20in%20people%20with%20type%202%20diabetes%20a%20randomized%20controlled%20trial.pdf
http://psasir.upm.edu.my/id/eprint/56203/
https://rd.springer.com/article/10.1007/s00394-016-1199-8
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spelling my.upm.eprints.562032017-07-04T02:46:16Z http://psasir.upm.edu.my/id/eprint/56203/ Effect of multi-strain probiotics (multi-strain microbial cell preparation) on glycemic control and other diabetes-related outcomes in people with type 2 diabetes: a randomized controlled trial Firouzi, Somayyeh Abdul Majid, Hazreen Ismail, Amin Kamaruddin, Nor Azmi Mohd Yusof, Barakatun Nisak Aim: Evidence of a possible connection between gut microbiota and several physiological processes linked to type 2 diabetes is increasing. However, the effect of multi-strain probiotics in people with type 2 diabetes remains unclear. This study investigated the effect of multi-strain microbial cell preparation—also refers to multi-strain probiotics—on glycemic control and other diabetes-related outcomes in people with type 2 diabetes. Design: A randomized, double-blind, parallel-group, controlled clinical trial. Setting: Diabetes clinic of a teaching hospital in Kuala Lumpur, Malaysia. Participants: A total of 136 participants with type 2 diabetes, aged 30–70 years, were recruited and randomly assigned to receive either probiotics (n = 68) or placebo (n = 68) for 12 weeks. Outcomes: Primary outcomes were glycemic control-related parameters, and secondary outcomes were anthropomorphic variables, lipid profile, blood pressure and high-sensitivity C-reactive protein. The Lactobacillus and Bifidobacterium quantities were measured before and after intervention as an indicator of successful passage of the supplement through gastrointestinal tract. Statistical analysis: Intention-to-treat (ITT) analysis was performed on all participants, while per-protocol (PP) analysis was performed on those participants who had successfully completed the trial with good compliance rate. Results: With respect to primary outcomes, glycated hemoglobin decreased by 0.14 % in the probiotics and increased by 0.02 % in the placebo group in PP analysis (p < 0.05, small effect size of 0.050), while these changes were not significant in ITT analysis. Fasting insulin increased by 1.8 µU/mL in placebo group and decreased by 2.9 µU/mL in probiotics group in PP analysis. These changes were significant between groups at both analyses (p < 0.05, medium effect size of 0.062 in PP analysis and small effect size of 0.033 in ITT analysis). Secondary outcomes did not change significantly. Probiotics successfully passed through the gastrointestinal tract. Conclusion: Probiotics modestly improved HbA1c and fasting insulin in people with type 2 diabetes. Springer 2017 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/56203/1/Effect%20of%20multi-strain%20probiotics%20%28multi-strain%20microbial%20cell%20preparation%29%20on%20glycemic%20control%20and%20other%20diabetes-related%20outcomes%20in%20people%20with%20type%202%20diabetes%20a%20randomized%20controlled%20trial.pdf Firouzi, Somayyeh and Abdul Majid, Hazreen and Ismail, Amin and Kamaruddin, Nor Azmi and Mohd Yusof, Barakatun Nisak (2017) Effect of multi-strain probiotics (multi-strain microbial cell preparation) on glycemic control and other diabetes-related outcomes in people with type 2 diabetes: a randomized controlled trial. European Journal of Nutrition, 56 (4). pp. 1535-1550. ISSN 1436-6207; ESSN: 1436-6215 https://rd.springer.com/article/10.1007/s00394-016-1199-8 10.1007/s00394-016-1199-8
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Aim: Evidence of a possible connection between gut microbiota and several physiological processes linked to type 2 diabetes is increasing. However, the effect of multi-strain probiotics in people with type 2 diabetes remains unclear. This study investigated the effect of multi-strain microbial cell preparation—also refers to multi-strain probiotics—on glycemic control and other diabetes-related outcomes in people with type 2 diabetes. Design: A randomized, double-blind, parallel-group, controlled clinical trial. Setting: Diabetes clinic of a teaching hospital in Kuala Lumpur, Malaysia. Participants: A total of 136 participants with type 2 diabetes, aged 30–70 years, were recruited and randomly assigned to receive either probiotics (n = 68) or placebo (n = 68) for 12 weeks. Outcomes: Primary outcomes were glycemic control-related parameters, and secondary outcomes were anthropomorphic variables, lipid profile, blood pressure and high-sensitivity C-reactive protein. The Lactobacillus and Bifidobacterium quantities were measured before and after intervention as an indicator of successful passage of the supplement through gastrointestinal tract. Statistical analysis: Intention-to-treat (ITT) analysis was performed on all participants, while per-protocol (PP) analysis was performed on those participants who had successfully completed the trial with good compliance rate. Results: With respect to primary outcomes, glycated hemoglobin decreased by 0.14 % in the probiotics and increased by 0.02 % in the placebo group in PP analysis (p < 0.05, small effect size of 0.050), while these changes were not significant in ITT analysis. Fasting insulin increased by 1.8 µU/mL in placebo group and decreased by 2.9 µU/mL in probiotics group in PP analysis. These changes were significant between groups at both analyses (p < 0.05, medium effect size of 0.062 in PP analysis and small effect size of 0.033 in ITT analysis). Secondary outcomes did not change significantly. Probiotics successfully passed through the gastrointestinal tract. Conclusion: Probiotics modestly improved HbA1c and fasting insulin in people with type 2 diabetes.
format Article
author Firouzi, Somayyeh
Abdul Majid, Hazreen
Ismail, Amin
Kamaruddin, Nor Azmi
Mohd Yusof, Barakatun Nisak
spellingShingle Firouzi, Somayyeh
Abdul Majid, Hazreen
Ismail, Amin
Kamaruddin, Nor Azmi
Mohd Yusof, Barakatun Nisak
Effect of multi-strain probiotics (multi-strain microbial cell preparation) on glycemic control and other diabetes-related outcomes in people with type 2 diabetes: a randomized controlled trial
author_facet Firouzi, Somayyeh
Abdul Majid, Hazreen
Ismail, Amin
Kamaruddin, Nor Azmi
Mohd Yusof, Barakatun Nisak
author_sort Firouzi, Somayyeh
title Effect of multi-strain probiotics (multi-strain microbial cell preparation) on glycemic control and other diabetes-related outcomes in people with type 2 diabetes: a randomized controlled trial
title_short Effect of multi-strain probiotics (multi-strain microbial cell preparation) on glycemic control and other diabetes-related outcomes in people with type 2 diabetes: a randomized controlled trial
title_full Effect of multi-strain probiotics (multi-strain microbial cell preparation) on glycemic control and other diabetes-related outcomes in people with type 2 diabetes: a randomized controlled trial
title_fullStr Effect of multi-strain probiotics (multi-strain microbial cell preparation) on glycemic control and other diabetes-related outcomes in people with type 2 diabetes: a randomized controlled trial
title_full_unstemmed Effect of multi-strain probiotics (multi-strain microbial cell preparation) on glycemic control and other diabetes-related outcomes in people with type 2 diabetes: a randomized controlled trial
title_sort effect of multi-strain probiotics (multi-strain microbial cell preparation) on glycemic control and other diabetes-related outcomes in people with type 2 diabetes: a randomized controlled trial
publisher Springer
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/56203/1/Effect%20of%20multi-strain%20probiotics%20%28multi-strain%20microbial%20cell%20preparation%29%20on%20glycemic%20control%20and%20other%20diabetes-related%20outcomes%20in%20people%20with%20type%202%20diabetes%20a%20randomized%20controlled%20trial.pdf
http://psasir.upm.edu.my/id/eprint/56203/
https://rd.springer.com/article/10.1007/s00394-016-1199-8
_version_ 1643836121152487424
score 13.211869

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