Silicon nanowire interface circuit for DNA detection

Detection and quantification of DNA is critical to many areas of life sciences and health care, from disease diagnosis to drug screening. The transduction of DNA through electrochemical methods have a fast response rate and with a conductometric device like the silicon nanowire which can be fabricat...

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Main Authors: Usman, Kamilu Iman, Hamidon, Mohd Nizar, Abd Rahman, Siti Fatimah, Sim, Guan Ling
Format: Article
Language:English
Published: Universiti Putra Malaysia Press 2017
Online Access:http://psasir.upm.edu.my/id/eprint/55881/1/29-JTS%28S%29-0143-2016-4thProof.pdf
http://psasir.upm.edu.my/id/eprint/55881/
http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JST%20Vol.%2025%20(S)%20Feb.%202017/29-JTS(S)-0143-2016-4thProof.pdf
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spelling my.upm.eprints.558812017-07-05T03:35:12Z http://psasir.upm.edu.my/id/eprint/55881/ Silicon nanowire interface circuit for DNA detection Usman, Kamilu Iman Hamidon, Mohd Nizar Abd Rahman, Siti Fatimah Sim, Guan Ling Detection and quantification of DNA is critical to many areas of life sciences and health care, from disease diagnosis to drug screening. The transduction of DNA through electrochemical methods have a fast response rate and with a conductometric device like the silicon nanowire which can be fabricated to have a similar diameter of the DNA molecule being targeted, detection is real-time. Critical to this is the interfacing of a current-source and an amplifier capable of achieving a maximum of 10 pico ampere input bias. In this project, we fabricated a silicon nanowire using the top down approach and built a circuit that can mimic the output signal as low as 12 nA and achieved a gain of 1 million to be interfaced with the nanowire for real-time DNA detection. Universiti Putra Malaysia Press 2017 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/55881/1/29-JTS%28S%29-0143-2016-4thProof.pdf Usman, Kamilu Iman and Hamidon, Mohd Nizar and Abd Rahman, Siti Fatimah and Sim, Guan Ling (2017) Silicon nanowire interface circuit for DNA detection. Pertanika Journal of Science & Technology, 25 (spec. Feb.). pp. 251-258. ISSN 0128-7680; ESSN: 2231-8526 http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JST%20Vol.%2025%20(S)%20Feb.%202017/29-JTS(S)-0143-2016-4thProof.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Detection and quantification of DNA is critical to many areas of life sciences and health care, from disease diagnosis to drug screening. The transduction of DNA through electrochemical methods have a fast response rate and with a conductometric device like the silicon nanowire which can be fabricated to have a similar diameter of the DNA molecule being targeted, detection is real-time. Critical to this is the interfacing of a current-source and an amplifier capable of achieving a maximum of 10 pico ampere input bias. In this project, we fabricated a silicon nanowire using the top down approach and built a circuit that can mimic the output signal as low as 12 nA and achieved a gain of 1 million to be interfaced with the nanowire for real-time DNA detection.
format Article
author Usman, Kamilu Iman
Hamidon, Mohd Nizar
Abd Rahman, Siti Fatimah
Sim, Guan Ling
spellingShingle Usman, Kamilu Iman
Hamidon, Mohd Nizar
Abd Rahman, Siti Fatimah
Sim, Guan Ling
Silicon nanowire interface circuit for DNA detection
author_facet Usman, Kamilu Iman
Hamidon, Mohd Nizar
Abd Rahman, Siti Fatimah
Sim, Guan Ling
author_sort Usman, Kamilu Iman
title Silicon nanowire interface circuit for DNA detection
title_short Silicon nanowire interface circuit for DNA detection
title_full Silicon nanowire interface circuit for DNA detection
title_fullStr Silicon nanowire interface circuit for DNA detection
title_full_unstemmed Silicon nanowire interface circuit for DNA detection
title_sort silicon nanowire interface circuit for dna detection
publisher Universiti Putra Malaysia Press
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/55881/1/29-JTS%28S%29-0143-2016-4thProof.pdf
http://psasir.upm.edu.my/id/eprint/55881/
http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JST%20Vol.%2025%20(S)%20Feb.%202017/29-JTS(S)-0143-2016-4thProof.pdf
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score 13.211869