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Does high public health expenditure slow down economic growth?

The Fritillaria imperialis is an ornamental flower that can be found in various parts of the world including Iraq, Afghanistan, Pakistan, and the Himalayas. The use of this plant as traditional remedy is widely known. This study aims to unveil the anti-cancer potentials of Isopimara-7,15-Dien-19-Oic...

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Main Authors: Sirag, Abdalla, Mohamed Nor, Norashidah, Raja Abdullah, Nik Mustapha, Karimi, Mohammad
Format: Article
Language:English
Published: ASERS Publishing 2016
Online Access:http://psasir.upm.edu.my/id/eprint/55560/1/Does%20high%20public%20health%20expenditure%20slow%20down%20economic%20growth.docx.pdf
http://psasir.upm.edu.my/id/eprint/55560/
https://www.ceeol.com/search/article-detail?id=535511
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spelling my.upm.eprints.555602017-08-14T10:03:15Z http://psasir.upm.edu.my/id/eprint/55560/ Does high public health expenditure slow down economic growth? Sirag, Abdalla Mohamed Nor, Norashidah Raja Abdullah, Nik Mustapha Karimi, Mohammad The Fritillaria imperialis is an ornamental flower that can be found in various parts of the world including Iraq, Afghanistan, Pakistan, and the Himalayas. The use of this plant as traditional remedy is widely known. This study aims to unveil the anti-cancer potentials of Isopimara-7,15-Dien-19-Oic Acid, extracted from the bulbs of F. imperialis in cervical cancer cell line, HeLa cells. Flow cytometry analysis of cell death, gene expression analysis via cDNA microarray and protein array were performed. Based on the results, Isopimara-7,15-Dien-19-Oic acid simultaneously induced cell death and promoted cell survival. The execution of apoptosis was apparent based on the flow cytometry results and regulation of both pro and anti-apoptotic genes. Additionally, the regulation of anti-oxidant genes were up-regulated especially thioredoxin, glutathione and superoxide dismutase- related genes. Moreover, the treatment also induced the activation of pro-survival heat shock proteins. Collectively, Isopimara-7,15-Dien-19-Oic Acid managed to induce cellular stress in HeLa cells and activate several anti- and pro survival pathways. ASERS Publishing 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/55560/1/Does%20high%20public%20health%20expenditure%20slow%20down%20economic%20growth.docx.pdf Sirag, Abdalla and Mohamed Nor, Norashidah and Raja Abdullah, Nik Mustapha and Karimi, Mohammad (2016) Does high public health expenditure slow down economic growth? Journal of Applied Economic Sciences, 11 (1(39)). pp. 5-17. ISSN 1843-6110 https://www.ceeol.com/search/article-detail?id=535511
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The Fritillaria imperialis is an ornamental flower that can be found in various parts of the world including Iraq, Afghanistan, Pakistan, and the Himalayas. The use of this plant as traditional remedy is widely known. This study aims to unveil the anti-cancer potentials of Isopimara-7,15-Dien-19-Oic Acid, extracted from the bulbs of F. imperialis in cervical cancer cell line, HeLa cells. Flow cytometry analysis of cell death, gene expression analysis via cDNA microarray and protein array were performed. Based on the results, Isopimara-7,15-Dien-19-Oic acid simultaneously induced cell death and promoted cell survival. The execution of apoptosis was apparent based on the flow cytometry results and regulation of both pro and anti-apoptotic genes. Additionally, the regulation of anti-oxidant genes were up-regulated especially thioredoxin, glutathione and superoxide dismutase- related genes. Moreover, the treatment also induced the activation of pro-survival heat shock proteins. Collectively, Isopimara-7,15-Dien-19-Oic Acid managed to induce cellular stress in HeLa cells and activate several anti- and pro survival pathways.
format Article
author Sirag, Abdalla
Mohamed Nor, Norashidah
Raja Abdullah, Nik Mustapha
Karimi, Mohammad
spellingShingle Sirag, Abdalla
Mohamed Nor, Norashidah
Raja Abdullah, Nik Mustapha
Karimi, Mohammad
Does high public health expenditure slow down economic growth?
author_facet Sirag, Abdalla
Mohamed Nor, Norashidah
Raja Abdullah, Nik Mustapha
Karimi, Mohammad
author_sort Sirag, Abdalla
title Does high public health expenditure slow down economic growth?
title_short Does high public health expenditure slow down economic growth?
title_full Does high public health expenditure slow down economic growth?
title_fullStr Does high public health expenditure slow down economic growth?
title_full_unstemmed Does high public health expenditure slow down economic growth?
title_sort does high public health expenditure slow down economic growth?
publisher ASERS Publishing
publishDate 2016
url http://psasir.upm.edu.my/id/eprint/55560/1/Does%20high%20public%20health%20expenditure%20slow%20down%20economic%20growth.docx.pdf
http://psasir.upm.edu.my/id/eprint/55560/
https://www.ceeol.com/search/article-detail?id=535511
_version_ 1643835931406368768
score 13.211869

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