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Chemopreventive properties and toxicity of kelulut honey in Sprague Dawley rats induced with azoxymethane

Ethnopharmacological Relevance. Colon cancer has been a major problem worldwide. Kelulut honey (KH) is produced by the stingless bees from Trigona species and has strong antioxidant activities that could be one of the potential chemopreventive agents from natural resources. Aim of This Study. This s...

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Main Authors: Saiful Yazan, Latifah, Muhamad Zali, Muhamad Firdaus Shyfiq, Mohd Ali, Razana, Zainal, Nurul Amira, Esa, Nurulaidah, Sapuan, Sarah, Yong, Sze Ong, Yin, Sim Tor, Gopalsamy, Banulata, Fui, Ling Voon, Syed Alwi, Sharifah Sakinah
Format: Article
Language:English
Published: Hindawi Publishing Corporation 2016
Online Access:http://psasir.upm.edu.my/id/eprint/55279/1/Chemopreventive%20Properties%20and%20Toxicity%20of%20Kelulut%20Honey%20in%20Sprague%20Dawley%20Rats%20Induced%20with%20Azoxymethane.pdf
http://psasir.upm.edu.my/id/eprint/55279/
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spelling my.upm.eprints.552792018-08-15T09:04:17Z http://psasir.upm.edu.my/id/eprint/55279/ Chemopreventive properties and toxicity of kelulut honey in Sprague Dawley rats induced with azoxymethane Saiful Yazan, Latifah Muhamad Zali, Muhamad Firdaus Shyfiq Mohd Ali, Razana Zainal, Nurul Amira Esa, Nurulaidah Sapuan, Sarah Yong, Sze Ong Yin, Sim Tor Gopalsamy, Banulata Fui, Ling Voon Syed Alwi, Sharifah Sakinah Ethnopharmacological Relevance. Colon cancer has been a major problem worldwide. Kelulut honey (KH) is produced by the stingless bees from Trigona species and has strong antioxidant activities that could be one of the potential chemopreventive agents from natural resources. Aim of This Study. This study investigated the chemopreventive properties and toxicity of KH in Sprague Dawley rats induced with azoxymethane (AOM). Material and Method. Twenty-four male Sprague Dawley rats aged 5 weeks were divided into 4 groups: (G1) untreated group not induced with AOM, (G2) untreated group induced with AOM, (G3) treated group induced with AOM, and (G4) treated group not induced with AOM. Injection of AOM (15 mg/kg) was via intraperitoneal route once a week for two subsequent weeks. The treatment groups were given oral administration of KH (1183 mg/kg body weight) twice daily for 8 weeks. Results. Treatment with KH significantly reduced the total number of aberrant crypt foci (ACF) and aberrant crypts (AC) and crypt multiplicity. KH was not toxic to the animals since the level of blood profile parameters, liver enzymes, and kidney functions was in normal range. Conclusions. The current finding shows that KH has chemopreventive properties in rats induced with colorectal cancer and also was found not toxic towards the animals. Hindawi Publishing Corporation 2016 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/55279/1/Chemopreventive%20Properties%20and%20Toxicity%20of%20Kelulut%20Honey%20in%20Sprague%20Dawley%20Rats%20Induced%20with%20Azoxymethane.pdf Saiful Yazan, Latifah and Muhamad Zali, Muhamad Firdaus Shyfiq and Mohd Ali, Razana and Zainal, Nurul Amira and Esa, Nurulaidah and Sapuan, Sarah and Yong, Sze Ong and Yin, Sim Tor and Gopalsamy, Banulata and Fui, Ling Voon and Syed Alwi, Sharifah Sakinah (2016) Chemopreventive properties and toxicity of kelulut honey in Sprague Dawley rats induced with azoxymethane. BioMed Research International, 2016. art. no. 4036926. pp. 1-7. ISSN 2314-6133; ESSN: 2314-6141 10.1155/2016/4036926
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Ethnopharmacological Relevance. Colon cancer has been a major problem worldwide. Kelulut honey (KH) is produced by the stingless bees from Trigona species and has strong antioxidant activities that could be one of the potential chemopreventive agents from natural resources. Aim of This Study. This study investigated the chemopreventive properties and toxicity of KH in Sprague Dawley rats induced with azoxymethane (AOM). Material and Method. Twenty-four male Sprague Dawley rats aged 5 weeks were divided into 4 groups: (G1) untreated group not induced with AOM, (G2) untreated group induced with AOM, (G3) treated group induced with AOM, and (G4) treated group not induced with AOM. Injection of AOM (15 mg/kg) was via intraperitoneal route once a week for two subsequent weeks. The treatment groups were given oral administration of KH (1183 mg/kg body weight) twice daily for 8 weeks. Results. Treatment with KH significantly reduced the total number of aberrant crypt foci (ACF) and aberrant crypts (AC) and crypt multiplicity. KH was not toxic to the animals since the level of blood profile parameters, liver enzymes, and kidney functions was in normal range. Conclusions. The current finding shows that KH has chemopreventive properties in rats induced with colorectal cancer and also was found not toxic towards the animals.
format Article
author Saiful Yazan, Latifah
Muhamad Zali, Muhamad Firdaus Shyfiq
Mohd Ali, Razana
Zainal, Nurul Amira
Esa, Nurulaidah
Sapuan, Sarah
Yong, Sze Ong
Yin, Sim Tor
Gopalsamy, Banulata
Fui, Ling Voon
Syed Alwi, Sharifah Sakinah
spellingShingle Saiful Yazan, Latifah
Muhamad Zali, Muhamad Firdaus Shyfiq
Mohd Ali, Razana
Zainal, Nurul Amira
Esa, Nurulaidah
Sapuan, Sarah
Yong, Sze Ong
Yin, Sim Tor
Gopalsamy, Banulata
Fui, Ling Voon
Syed Alwi, Sharifah Sakinah
Chemopreventive properties and toxicity of kelulut honey in Sprague Dawley rats induced with azoxymethane
author_facet Saiful Yazan, Latifah
Muhamad Zali, Muhamad Firdaus Shyfiq
Mohd Ali, Razana
Zainal, Nurul Amira
Esa, Nurulaidah
Sapuan, Sarah
Yong, Sze Ong
Yin, Sim Tor
Gopalsamy, Banulata
Fui, Ling Voon
Syed Alwi, Sharifah Sakinah
author_sort Saiful Yazan, Latifah
title Chemopreventive properties and toxicity of kelulut honey in Sprague Dawley rats induced with azoxymethane
title_short Chemopreventive properties and toxicity of kelulut honey in Sprague Dawley rats induced with azoxymethane
title_full Chemopreventive properties and toxicity of kelulut honey in Sprague Dawley rats induced with azoxymethane
title_fullStr Chemopreventive properties and toxicity of kelulut honey in Sprague Dawley rats induced with azoxymethane
title_full_unstemmed Chemopreventive properties and toxicity of kelulut honey in Sprague Dawley rats induced with azoxymethane
title_sort chemopreventive properties and toxicity of kelulut honey in sprague dawley rats induced with azoxymethane
publisher Hindawi Publishing Corporation
publishDate 2016
url http://psasir.upm.edu.my/id/eprint/55279/1/Chemopreventive%20Properties%20and%20Toxicity%20of%20Kelulut%20Honey%20in%20Sprague%20Dawley%20Rats%20Induced%20with%20Azoxymethane.pdf
http://psasir.upm.edu.my/id/eprint/55279/
_version_ 1643835848166211584
score 13.211869

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