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Antidepressant-like effect of lipid extract of Channa striatus in chronic unpredictable mild stress model of depression in rats

This study evaluated the antidepressant-like effect of lipid extract of C. striatus in chronic unpredictablemild stress (CUMS)model of depression in male rats and its mechanism of action. The animals were subjected to CUMS for six weeks by using variety of stressors. At the end of CUMS protocol, ani...

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Main Authors: Abdul Shukkoor, Mohamed Saleem, Baharuldin, Mohamad Taufik Hidayat, Mat Jais, Abdul Manan, Mohamad Moklas, Mohamad Aris, Fakurazi, Sharida
Format: Article
Language:English
Published: Hindawi Publishing Corporation 2016
Online Access:http://psasir.upm.edu.my/id/eprint/55080/1/Antidepressant-like%20effect%20of%20lipid%20extract%20of%20Channa%20striatus%20in%20chronic%20unpredictable%20mild%20stress%20model%20of%20depression%20in%20rats.pdf
http://psasir.upm.edu.my/id/eprint/55080/
https://www.hindawi.com/journals/ecam/
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spelling my.upm.eprints.550802018-01-19T03:54:46Z http://psasir.upm.edu.my/id/eprint/55080/ Antidepressant-like effect of lipid extract of Channa striatus in chronic unpredictable mild stress model of depression in rats Abdul Shukkoor, Mohamed Saleem Baharuldin, Mohamad Taufik Hidayat Mat Jais, Abdul Manan Mohamad Moklas, Mohamad Aris Fakurazi, Sharida This study evaluated the antidepressant-like effect of lipid extract of C. striatus in chronic unpredictablemild stress (CUMS)model of depression in male rats and its mechanism of action. The animals were subjected to CUMS for six weeks by using variety of stressors. At the end of CUMS protocol, animals were subjected to forced swimming test (FST) and open field test followed by biochemical assay. The CUMS protocol produced depressive-like behavior in rats by decreasing the body weight, decreasing the sucrose preference, and increasing the duration of immobility in FST. The CUMS protocol increased plasma corticosterone and decreased hippocampal and prefrontal cortex levels of monoamines (serotonin, noradrenaline, and dopamine) and brain-derived neurotrophic factor. Further, the CUMS protocol increased interleukin-6 (in hippocampus and prefrontal cortex) and nuclear factor-kappa B (in prefrontal cortex but not in hippocampus).The lipid extract of C. striatus (125, 250, and 500mg/kg) significantly ( Hindawi Publishing Corporation 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/55080/1/Antidepressant-like%20effect%20of%20lipid%20extract%20of%20Channa%20striatus%20in%20chronic%20unpredictable%20mild%20stress%20model%20of%20depression%20in%20rats.pdf Abdul Shukkoor, Mohamed Saleem and Baharuldin, Mohamad Taufik Hidayat and Mat Jais, Abdul Manan and Mohamad Moklas, Mohamad Aris and Fakurazi, Sharida (2016) Antidepressant-like effect of lipid extract of Channa striatus in chronic unpredictable mild stress model of depression in rats. Evidence-Based Complementary and Alternative Medicine . art. no. 2986090. pp. 1-17. ISSN 1741-4288 https://www.hindawi.com/journals/ecam/ 10.1155/2016/2986090
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description This study evaluated the antidepressant-like effect of lipid extract of C. striatus in chronic unpredictablemild stress (CUMS)model of depression in male rats and its mechanism of action. The animals were subjected to CUMS for six weeks by using variety of stressors. At the end of CUMS protocol, animals were subjected to forced swimming test (FST) and open field test followed by biochemical assay. The CUMS protocol produced depressive-like behavior in rats by decreasing the body weight, decreasing the sucrose preference, and increasing the duration of immobility in FST. The CUMS protocol increased plasma corticosterone and decreased hippocampal and prefrontal cortex levels of monoamines (serotonin, noradrenaline, and dopamine) and brain-derived neurotrophic factor. Further, the CUMS protocol increased interleukin-6 (in hippocampus and prefrontal cortex) and nuclear factor-kappa B (in prefrontal cortex but not in hippocampus).The lipid extract of C. striatus (125, 250, and 500mg/kg) significantly (
format Article
author Abdul Shukkoor, Mohamed Saleem
Baharuldin, Mohamad Taufik Hidayat
Mat Jais, Abdul Manan
Mohamad Moklas, Mohamad Aris
Fakurazi, Sharida
spellingShingle Abdul Shukkoor, Mohamed Saleem
Baharuldin, Mohamad Taufik Hidayat
Mat Jais, Abdul Manan
Mohamad Moklas, Mohamad Aris
Fakurazi, Sharida
Antidepressant-like effect of lipid extract of Channa striatus in chronic unpredictable mild stress model of depression in rats
author_facet Abdul Shukkoor, Mohamed Saleem
Baharuldin, Mohamad Taufik Hidayat
Mat Jais, Abdul Manan
Mohamad Moklas, Mohamad Aris
Fakurazi, Sharida
author_sort Abdul Shukkoor, Mohamed Saleem
title Antidepressant-like effect of lipid extract of Channa striatus in chronic unpredictable mild stress model of depression in rats
title_short Antidepressant-like effect of lipid extract of Channa striatus in chronic unpredictable mild stress model of depression in rats
title_full Antidepressant-like effect of lipid extract of Channa striatus in chronic unpredictable mild stress model of depression in rats
title_fullStr Antidepressant-like effect of lipid extract of Channa striatus in chronic unpredictable mild stress model of depression in rats
title_full_unstemmed Antidepressant-like effect of lipid extract of Channa striatus in chronic unpredictable mild stress model of depression in rats
title_sort antidepressant-like effect of lipid extract of channa striatus in chronic unpredictable mild stress model of depression in rats
publisher Hindawi Publishing Corporation
publishDate 2016
url http://psasir.upm.edu.my/id/eprint/55080/1/Antidepressant-like%20effect%20of%20lipid%20extract%20of%20Channa%20striatus%20in%20chronic%20unpredictable%20mild%20stress%20model%20of%20depression%20in%20rats.pdf
http://psasir.upm.edu.my/id/eprint/55080/
https://www.hindawi.com/journals/ecam/
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score 13.211869

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