Cover Image

Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats

Introduction: This study was conducted to determine immunological and metabolic effects of different concentrations of ginger rhizome (Zingiber officinale Roscoe) in streptozotocin (STZ)-nicotinamide (NA) induced diabetic rats. Methods: Forty-eight fasted male Sprague-Dawley rats were induced diabet...

Full description

Saved in:
Bibliographic Details
Main Authors: Mojani, Mansooreh Sadat, Rahmat, Asmah, Ramasamy, Rajesh, Sarmadi, Vahid Hosseinpour, Sandrasaigaran, Pratheep, Vellasamy, Shalini, Hejazi, Seyed Majid Akhavan
Format: Article
Language:English
Published: Nutrition Society of Malaysia 2016
Online Access:http://psasir.upm.edu.my/id/eprint/54791/1/Metabolic%20and%20immunologic%20alterations%20of%20ginger%20rhizome%20among%20streptozotocin-nicotinamide%20induced%20diabetic%20rats.pdf
http://psasir.upm.edu.my/id/eprint/54791/
https://www.cabdirect.org/cabdirect/abstract/20173161042
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.54791
record_format eprints
spelling my.upm.eprints.547912018-04-24T04:59:49Z http://psasir.upm.edu.my/id/eprint/54791/ Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats Mojani, Mansooreh Sadat Rahmat, Asmah Ramasamy, Rajesh Sarmadi, Vahid Hosseinpour Sandrasaigaran, Pratheep Vellasamy, Shalini Hejazi, Seyed Majid Akhavan Introduction: This study was conducted to determine immunological and metabolic effects of different concentrations of ginger rhizome (Zingiber officinale Roscoe) in streptozotocin (STZ)-nicotinamide (NA) induced diabetic rats. Methods: Forty-eight fasted male Sprague-Dawley rats were induced diabetes using a single intraperitoneal injection of NA(110 mg/kg b.w.) and STZ (65 mg/kg b.w, 15 min after NA). Diabetic rats orally received either different concentrations (250, 500 and 750 mg/kg body weight) of ginger rhizome suspension or glibenclamide (10 mg/kg body weight) for 6 weeks. Two control diabetic and normal groups were gavaged with only distilled water as a vehicle. Results: The results indicated that the lower concentrations of ginger modulated body weight, fasting blood glucose, level of triglyceride and tumor necrosis factor-α (TNF-α) (p<0.05). In contrast, ginger could not enhance atherogenic indices due to a decline in the level of HDL-c. Immunological features of ginger were evident by a significant lymphocyte proliferation in all treated groups at stimulation by 5 mg/ml PHA (p<0.001). Level of CD45ra+ (B cell marker) increased significantly in the lowest dose of ginger (p<0.05, 58%), and 250 mg/kg body weight of ginger was found to be safe for not altering the level of CD4+CD25+ marker (p>0.05). Conclusion: Ginger indicated better impact on metabolic and immunologic parameters in lower doses of supplementation compared with high doses of treatment. Nutrition Society of Malaysia 2016 Article NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/54791/1/Metabolic%20and%20immunologic%20alterations%20of%20ginger%20rhizome%20among%20streptozotocin-nicotinamide%20induced%20diabetic%20rats.pdf Mojani, Mansooreh Sadat and Rahmat, Asmah and Ramasamy, Rajesh and Sarmadi, Vahid Hosseinpour and Sandrasaigaran, Pratheep and Vellasamy, Shalini and Hejazi, Seyed Majid Akhavan (2016) Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats. Malaysian Journal of Nutrition, 22 (3). pp. 421-432. ISSN 1394-035X https://www.cabdirect.org/cabdirect/abstract/20173161042
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Introduction: This study was conducted to determine immunological and metabolic effects of different concentrations of ginger rhizome (Zingiber officinale Roscoe) in streptozotocin (STZ)-nicotinamide (NA) induced diabetic rats. Methods: Forty-eight fasted male Sprague-Dawley rats were induced diabetes using a single intraperitoneal injection of NA(110 mg/kg b.w.) and STZ (65 mg/kg b.w, 15 min after NA). Diabetic rats orally received either different concentrations (250, 500 and 750 mg/kg body weight) of ginger rhizome suspension or glibenclamide (10 mg/kg body weight) for 6 weeks. Two control diabetic and normal groups were gavaged with only distilled water as a vehicle. Results: The results indicated that the lower concentrations of ginger modulated body weight, fasting blood glucose, level of triglyceride and tumor necrosis factor-α (TNF-α) (p<0.05). In contrast, ginger could not enhance atherogenic indices due to a decline in the level of HDL-c. Immunological features of ginger were evident by a significant lymphocyte proliferation in all treated groups at stimulation by 5 mg/ml PHA (p<0.001). Level of CD45ra+ (B cell marker) increased significantly in the lowest dose of ginger (p<0.05, 58%), and 250 mg/kg body weight of ginger was found to be safe for not altering the level of CD4+CD25+ marker (p>0.05). Conclusion: Ginger indicated better impact on metabolic and immunologic parameters in lower doses of supplementation compared with high doses of treatment.
format Article
author Mojani, Mansooreh Sadat
Rahmat, Asmah
Ramasamy, Rajesh
Sarmadi, Vahid Hosseinpour
Sandrasaigaran, Pratheep
Vellasamy, Shalini
Hejazi, Seyed Majid Akhavan
spellingShingle Mojani, Mansooreh Sadat
Rahmat, Asmah
Ramasamy, Rajesh
Sarmadi, Vahid Hosseinpour
Sandrasaigaran, Pratheep
Vellasamy, Shalini
Hejazi, Seyed Majid Akhavan
Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats
author_facet Mojani, Mansooreh Sadat
Rahmat, Asmah
Ramasamy, Rajesh
Sarmadi, Vahid Hosseinpour
Sandrasaigaran, Pratheep
Vellasamy, Shalini
Hejazi, Seyed Majid Akhavan
author_sort Mojani, Mansooreh Sadat
title Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats
title_short Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats
title_full Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats
title_fullStr Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats
title_full_unstemmed Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats
title_sort metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats
publisher Nutrition Society of Malaysia
publishDate 2016
url http://psasir.upm.edu.my/id/eprint/54791/1/Metabolic%20and%20immunologic%20alterations%20of%20ginger%20rhizome%20among%20streptozotocin-nicotinamide%20induced%20diabetic%20rats.pdf
http://psasir.upm.edu.my/id/eprint/54791/
https://www.cabdirect.org/cabdirect/abstract/20173161042
_version_ 1643835707153711104
score 13.211869

Similar Items