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Less utilized prognostic markers in acute myeloid leukaemia

Acute myeloid leukemia (AML) results from the over-proliferation of progenitor cells of the myeloid lineage in the bone marrow. It is a heterogeneous disease that is aggressive and difficult to treat. AML diagnosis is based on clinical as well as laboratory investigations. Risk stratification is imp...

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Main Author: Abdullah, Maha
Format: Article
Language:English
Published: ACT Publishing Group 2016
Online Access:http://psasir.upm.edu.my/id/eprint/54711/1/Less%20utilized%20prognostic%20markers%20in%20acute%20myeloid%20leukemia.pdf
http://psasir.upm.edu.my/id/eprint/54711/
http://www.ghrnet.org/index.php/ijhr/article/view/1519/1868
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spelling my.upm.eprints.547112018-04-19T07:36:14Z http://psasir.upm.edu.my/id/eprint/54711/ Less utilized prognostic markers in acute myeloid leukaemia Abdullah, Maha Acute myeloid leukemia (AML) results from the over-proliferation of progenitor cells of the myeloid lineage in the bone marrow. It is a heterogeneous disease that is aggressive and difficult to treat. AML diagnosis is based on clinical as well as laboratory investigations. Risk stratification is important to assess risk of relapse. Current guidelines for risk stratification are dependent on identification of genetic aberrations particularly chromosomal translocations and gene mutations. Though these are observed in the majority of patients, the best treatment regimen remains elusive. AML blasts are assumed to have transformed from a normal counterpart and maintains many normal regulatory functions. Early features such as stem cell properties has long been proven to be linked to early relapse in AML. Leukaemia stem cells (LSC) are identified by high CD34 and negative CD38 expression. Aberrant expression of a third marker such as Thy-1/CD90 negativity, expression of CLL-1 and IL-3R (CD123), intermediate levels of aldehyde dehydrogenase and co-expression of common chromosomal translocation may be used to distinguish from normal hematopoietic stem cells. In vitro characteristics of AML blasts such as proliferation, survival or response to treatment are also able to predict patient response to therapy, replicative of its interaction with the microenvironment. These potential prognostic markers are well studied but are currently not considered in patient management. ACT Publishing Group 2016 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/54711/1/Less%20utilized%20prognostic%20markers%20in%20acute%20myeloid%20leukemia.pdf Abdullah, Maha (2016) Less utilized prognostic markers in acute myeloid leukaemia. International Journal of Hematology Research, 2 (1). pp. 95-102. ISSN 2409-3548; ESSN: 2409-5680 http://www.ghrnet.org/index.php/ijhr/article/view/1519/1868
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Acute myeloid leukemia (AML) results from the over-proliferation of progenitor cells of the myeloid lineage in the bone marrow. It is a heterogeneous disease that is aggressive and difficult to treat. AML diagnosis is based on clinical as well as laboratory investigations. Risk stratification is important to assess risk of relapse. Current guidelines for risk stratification are dependent on identification of genetic aberrations particularly chromosomal translocations and gene mutations. Though these are observed in the majority of patients, the best treatment regimen remains elusive. AML blasts are assumed to have transformed from a normal counterpart and maintains many normal regulatory functions. Early features such as stem cell properties has long been proven to be linked to early relapse in AML. Leukaemia stem cells (LSC) are identified by high CD34 and negative CD38 expression. Aberrant expression of a third marker such as Thy-1/CD90 negativity, expression of CLL-1 and IL-3R (CD123), intermediate levels of aldehyde dehydrogenase and co-expression of common chromosomal translocation may be used to distinguish from normal hematopoietic stem cells. In vitro characteristics of AML blasts such as proliferation, survival or response to treatment are also able to predict patient response to therapy, replicative of its interaction with the microenvironment. These potential prognostic markers are well studied but are currently not considered in patient management.
format Article
author Abdullah, Maha
spellingShingle Abdullah, Maha
Less utilized prognostic markers in acute myeloid leukaemia
author_facet Abdullah, Maha
author_sort Abdullah, Maha
title Less utilized prognostic markers in acute myeloid leukaemia
title_short Less utilized prognostic markers in acute myeloid leukaemia
title_full Less utilized prognostic markers in acute myeloid leukaemia
title_fullStr Less utilized prognostic markers in acute myeloid leukaemia
title_full_unstemmed Less utilized prognostic markers in acute myeloid leukaemia
title_sort less utilized prognostic markers in acute myeloid leukaemia
publisher ACT Publishing Group
publishDate 2016
url http://psasir.upm.edu.my/id/eprint/54711/1/Less%20utilized%20prognostic%20markers%20in%20acute%20myeloid%20leukemia.pdf
http://psasir.upm.edu.my/id/eprint/54711/
http://www.ghrnet.org/index.php/ijhr/article/view/1519/1868
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score 13.211869

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