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In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates

Four compounds, R3PAu[S2CN(CH2CH2OH)2], R = Ph (1) and cyclohexyl (2), and Et3PAuS2CNRꞌ2, Rꞌ = Rꞌ = Et (3) and Rꞌ2 = (CH2)4 (4), have been evaluated for antibacterial activity against a panel of 24 Gram positive (8) and Gram negative (16) bacteria. Based on minimum inhibitory concentration (MIC) sco...

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Main Authors: Chen, Bao Jing, Jamaludin, Nazzatush Shimar, Khoo, Chai Hoon, See, Tian Hong, Sim, Jiun Horng, Cheah, Yoke Kqueen, Abdul Halim, Siti Nadiah, Seng, Hoi Ling, Tiekink, Edward R.T.
Format: Article
Language:English
Published: Elsevier 2016
Online Access:http://psasir.upm.edu.my/id/eprint/54533/1/In%20vitro%20antibacterial%20and%20time%20kill%20evaluation%20of%20mononuclear%20phosphanegold%20%28I%29%20dithiocarbamates.pdf
http://psasir.upm.edu.my/id/eprint/54533/
https://www.sciencedirect.com/science/article/pii/S0162013416302264
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spelling my.upm.eprints.545332018-03-27T04:29:29Z http://psasir.upm.edu.my/id/eprint/54533/ In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates Chen, Bao Jing Jamaludin, Nazzatush Shimar Khoo, Chai Hoon See, Tian Hong Sim, Jiun Horng Cheah, Yoke Kqueen Abdul Halim, Siti Nadiah Seng, Hoi Ling Tiekink, Edward R.T. Four compounds, R3PAu[S2CN(CH2CH2OH)2], R = Ph (1) and cyclohexyl (2), and Et3PAuS2CNRꞌ2, Rꞌ = Rꞌ = Et (3) and Rꞌ2 = (CH2)4 (4), have been evaluated for antibacterial activity against a panel of 24 Gram positive (8) and Gram negative (16) bacteria. Based on minimum inhibitory concentration (MIC) scores, compounds 1 and 2 were shown to be specifically potent against Gram positive bacteria whereas compounds 3 and, to a lesser extent, 4 exhibited broad range activity. All four compounds were active against methicillin resistant Staphylococcus aureus (MRSA). Time kill assays revealed the compounds to exhibit both time- and concentration-dependent pharmacokinetics against susceptible bacteria. Each compound was bactericidal against one or more bacteria with 3 being especially potent after 8 h exposure; compounds 1 and 3 were bactericidal against MRSA. Compound 3 was the most effective bactericide across the series especially toward B. subtilis, S. saprophyticus, A. hydrophila, P. vulgaris, and V. parahaemolyticus. This study demonstrates the potential of this class of compounds as antibacterial agents, either broad range or against specific bacteria. Elsevier 2016-10 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/54533/1/In%20vitro%20antibacterial%20and%20time%20kill%20evaluation%20of%20mononuclear%20phosphanegold%20%28I%29%20dithiocarbamates.pdf Chen, Bao Jing and Jamaludin, Nazzatush Shimar and Khoo, Chai Hoon and See, Tian Hong and Sim, Jiun Horng and Cheah, Yoke Kqueen and Abdul Halim, Siti Nadiah and Seng, Hoi Ling and Tiekink, Edward R.T. (2016) In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates. Journal of Inorganic Biochemistry, 163. pp. 68-80. ISSN 0162-0134; ESSN: 1873-3344 https://www.sciencedirect.com/science/article/pii/S0162013416302264 10.1016/j.jinorgbio.2016.08.002
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Four compounds, R3PAu[S2CN(CH2CH2OH)2], R = Ph (1) and cyclohexyl (2), and Et3PAuS2CNRꞌ2, Rꞌ = Rꞌ = Et (3) and Rꞌ2 = (CH2)4 (4), have been evaluated for antibacterial activity against a panel of 24 Gram positive (8) and Gram negative (16) bacteria. Based on minimum inhibitory concentration (MIC) scores, compounds 1 and 2 were shown to be specifically potent against Gram positive bacteria whereas compounds 3 and, to a lesser extent, 4 exhibited broad range activity. All four compounds were active against methicillin resistant Staphylococcus aureus (MRSA). Time kill assays revealed the compounds to exhibit both time- and concentration-dependent pharmacokinetics against susceptible bacteria. Each compound was bactericidal against one or more bacteria with 3 being especially potent after 8 h exposure; compounds 1 and 3 were bactericidal against MRSA. Compound 3 was the most effective bactericide across the series especially toward B. subtilis, S. saprophyticus, A. hydrophila, P. vulgaris, and V. parahaemolyticus. This study demonstrates the potential of this class of compounds as antibacterial agents, either broad range or against specific bacteria.
format Article
author Chen, Bao Jing
Jamaludin, Nazzatush Shimar
Khoo, Chai Hoon
See, Tian Hong
Sim, Jiun Horng
Cheah, Yoke Kqueen
Abdul Halim, Siti Nadiah
Seng, Hoi Ling
Tiekink, Edward R.T.
spellingShingle Chen, Bao Jing
Jamaludin, Nazzatush Shimar
Khoo, Chai Hoon
See, Tian Hong
Sim, Jiun Horng
Cheah, Yoke Kqueen
Abdul Halim, Siti Nadiah
Seng, Hoi Ling
Tiekink, Edward R.T.
In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates
author_facet Chen, Bao Jing
Jamaludin, Nazzatush Shimar
Khoo, Chai Hoon
See, Tian Hong
Sim, Jiun Horng
Cheah, Yoke Kqueen
Abdul Halim, Siti Nadiah
Seng, Hoi Ling
Tiekink, Edward R.T.
author_sort Chen, Bao Jing
title In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates
title_short In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates
title_full In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates
title_fullStr In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates
title_full_unstemmed In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates
title_sort in vitro antibacterial and time kill evaluation of mononuclear phosphanegold(i) dithiocarbamates
publisher Elsevier
publishDate 2016
url http://psasir.upm.edu.my/id/eprint/54533/1/In%20vitro%20antibacterial%20and%20time%20kill%20evaluation%20of%20mononuclear%20phosphanegold%20%28I%29%20dithiocarbamates.pdf
http://psasir.upm.edu.my/id/eprint/54533/
https://www.sciencedirect.com/science/article/pii/S0162013416302264
_version_ 1643835656342863872
score 13.211869

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