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Stem cells therapy for treatment of ocular disorders

Sustenance of visual function is the ultimate focus of ophthalmologists. Failure of complete recovery of visual function and complications that follow conventional treatments have shifted search to a new form of therapy using stem cells. Stem cell progenitors play a major role in replenishing degene...

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Main Authors: Sivan, Padma Priya, Syed, Sakinah, Mok, Pooi Ling, Higuchi, Akon, Murugan, Kadarkarai, A. Alarfaj, Abdullah, Munusamy, Murugan A., Hamat, Rukman Awang, Umezawa, Akihiro, Kumar, Suresh
Format: Article
Language:English
Published: Hindawi Publishing Corporation 2016
Online Access:http://psasir.upm.edu.my/id/eprint/53893/1/Stem%20cells%20therapy%20for%20treatment%20of%20ocular%20disorders.pdf
http://psasir.upm.edu.my/id/eprint/53893/
https://www.hindawi.com/journals/sci/2016/8304879/abs/
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spelling my.upm.eprints.538932018-02-20T08:52:03Z http://psasir.upm.edu.my/id/eprint/53893/ Stem cells therapy for treatment of ocular disorders Sivan, Padma Priya Syed, Sakinah Mok, Pooi Ling Higuchi, Akon Murugan, Kadarkarai A. Alarfaj, Abdullah Munusamy, Murugan A. Hamat, Rukman Awang Umezawa, Akihiro Kumar, Suresh Sustenance of visual function is the ultimate focus of ophthalmologists. Failure of complete recovery of visual function and complications that follow conventional treatments have shifted search to a new form of therapy using stem cells. Stem cell progenitors play a major role in replenishing degenerated cells despite being present in low quantity and quiescence in our body. Unlike other tissues and cells, regeneration of new optic cells responsible for visual function is rarely observed. Understanding the transcription factors and genes responsible for optic cells development will assist scientists in formulating a strategy to activate and direct stem cells renewal and differentiation. We review the processes of human eye development and address the strategies that have been exploited in an effort to regain visual function in the preclinical and clinical state. The update of clinical findings of patients receiving stem cell treatment is also presented. Hindawi Publishing Corporation 2016 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/53893/1/Stem%20cells%20therapy%20for%20treatment%20of%20ocular%20disorders.pdf Sivan, Padma Priya and Syed, Sakinah and Mok, Pooi Ling and Higuchi, Akon and Murugan, Kadarkarai and A. Alarfaj, Abdullah and Munusamy, Murugan A. and Hamat, Rukman Awang and Umezawa, Akihiro and Kumar, Suresh (2016) Stem cells therapy for treatment of ocular disorders. Stem Cells International, 2016. art. no. 8304879. pp. 1-18. ISSN 1687-966X; ESSN: 1687-9678 https://www.hindawi.com/journals/sci/2016/8304879/abs/ 10.1155/2016/8304879
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Sustenance of visual function is the ultimate focus of ophthalmologists. Failure of complete recovery of visual function and complications that follow conventional treatments have shifted search to a new form of therapy using stem cells. Stem cell progenitors play a major role in replenishing degenerated cells despite being present in low quantity and quiescence in our body. Unlike other tissues and cells, regeneration of new optic cells responsible for visual function is rarely observed. Understanding the transcription factors and genes responsible for optic cells development will assist scientists in formulating a strategy to activate and direct stem cells renewal and differentiation. We review the processes of human eye development and address the strategies that have been exploited in an effort to regain visual function in the preclinical and clinical state. The update of clinical findings of patients receiving stem cell treatment is also presented.
format Article
author Sivan, Padma Priya
Syed, Sakinah
Mok, Pooi Ling
Higuchi, Akon
Murugan, Kadarkarai
A. Alarfaj, Abdullah
Munusamy, Murugan A.
Hamat, Rukman Awang
Umezawa, Akihiro
Kumar, Suresh
spellingShingle Sivan, Padma Priya
Syed, Sakinah
Mok, Pooi Ling
Higuchi, Akon
Murugan, Kadarkarai
A. Alarfaj, Abdullah
Munusamy, Murugan A.
Hamat, Rukman Awang
Umezawa, Akihiro
Kumar, Suresh
Stem cells therapy for treatment of ocular disorders
author_facet Sivan, Padma Priya
Syed, Sakinah
Mok, Pooi Ling
Higuchi, Akon
Murugan, Kadarkarai
A. Alarfaj, Abdullah
Munusamy, Murugan A.
Hamat, Rukman Awang
Umezawa, Akihiro
Kumar, Suresh
author_sort Sivan, Padma Priya
title Stem cells therapy for treatment of ocular disorders
title_short Stem cells therapy for treatment of ocular disorders
title_full Stem cells therapy for treatment of ocular disorders
title_fullStr Stem cells therapy for treatment of ocular disorders
title_full_unstemmed Stem cells therapy for treatment of ocular disorders
title_sort stem cells therapy for treatment of ocular disorders
publisher Hindawi Publishing Corporation
publishDate 2016
url http://psasir.upm.edu.my/id/eprint/53893/1/Stem%20cells%20therapy%20for%20treatment%20of%20ocular%20disorders.pdf
http://psasir.upm.edu.my/id/eprint/53893/
https://www.hindawi.com/journals/sci/2016/8304879/abs/
_version_ 1643835516815147008
score 13.211869

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