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Proteomic profile of acute myeloid leukaemia: a review update

Proteome analysis is a complex and dynamic process that encompasses several analytical platforms that include protein sequencing, structural or expression proteomics, protein modification, sub-cellular protein localization, protein-protein interaction and biological functional proteomics. In fact, e...

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Main Authors: Almaiman, Amer Abdulrahman, Abdullah, Rasedee, Abdul, Ahmad, Allauddin, Zeenathul, Eid, Eltayeb E. M., Saghir, Sultan Ayesh Mohammed
Format: Article
Language:English
Published: Pharmacotherapy Group, Faculty of Pharmacy, University of Benin 2016
Online Access:http://psasir.upm.edu.my/id/eprint/53696/1/Proteomic%20profile%20of%20acute%20myeloid%20leukaemia.pdf
http://psasir.upm.edu.my/id/eprint/53696/
https://www.ajol.info/index.php/tjpr/article/view/141960
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spelling my.upm.eprints.536962018-01-08T02:07:43Z http://psasir.upm.edu.my/id/eprint/53696/ Proteomic profile of acute myeloid leukaemia: a review update Almaiman, Amer Abdulrahman Abdullah, Rasedee Abdul, Ahmad Allauddin, Zeenathul Eid, Eltayeb E. M. Saghir, Sultan Ayesh Mohammed Proteome analysis is a complex and dynamic process that encompasses several analytical platforms that include protein sequencing, structural or expression proteomics, protein modification, sub-cellular protein localization, protein-protein interaction and biological functional proteomics. In fact, expression proteomics is extensively applied in a majority of biomarker detection studies because it provides a detailed overview of differentially expressed proteins in cellular pathways and disease processes. Proteomics are also effective and dynamic in protein-protein interactions and cross-talks between interacting molecules of the cell. Proteomics has evolved into a crucial tool used to investigate the biochemical changes that possibly lead to development of cancer biomarkers. This review draws attention to the progress and advancements in cancer proteomics technology with the aim of simplifying the understanding of the mechanisms underlying the disease and to contribute to detection of biomarkers in addition to the development of novel treatments. Given that proteome is a dynamic entity of cellular functions in health and disease, it is capable of reflecting the immediate environmental state of cells and tissues as shown in this review. The review shows the possibility of elucidating the pathophysiology of acute myeloid leukaemia (AML) through proteome expressions, thus confirming the viability of proteome analysis in profiling AML. Pharmacotherapy Group, Faculty of Pharmacy, University of Benin 2016-07 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/53696/1/Proteomic%20profile%20of%20acute%20myeloid%20leukaemia.pdf Almaiman, Amer Abdulrahman and Abdullah, Rasedee and Abdul, Ahmad and Allauddin, Zeenathul and Eid, Eltayeb E. M. and Saghir, Sultan Ayesh Mohammed (2016) Proteomic profile of acute myeloid leukaemia: a review update. Tropical Journal of Pharmaceutical Research, 15 (7). pp. 1569-1578. ISSN 1596-5996; ESSN: 1596-9827 https://www.ajol.info/index.php/tjpr/article/view/141960 10.4314/tjpr.v15i7.29
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Proteome analysis is a complex and dynamic process that encompasses several analytical platforms that include protein sequencing, structural or expression proteomics, protein modification, sub-cellular protein localization, protein-protein interaction and biological functional proteomics. In fact, expression proteomics is extensively applied in a majority of biomarker detection studies because it provides a detailed overview of differentially expressed proteins in cellular pathways and disease processes. Proteomics are also effective and dynamic in protein-protein interactions and cross-talks between interacting molecules of the cell. Proteomics has evolved into a crucial tool used to investigate the biochemical changes that possibly lead to development of cancer biomarkers. This review draws attention to the progress and advancements in cancer proteomics technology with the aim of simplifying the understanding of the mechanisms underlying the disease and to contribute to detection of biomarkers in addition to the development of novel treatments. Given that proteome is a dynamic entity of cellular functions in health and disease, it is capable of reflecting the immediate environmental state of cells and tissues as shown in this review. The review shows the possibility of elucidating the pathophysiology of acute myeloid leukaemia (AML) through proteome expressions, thus confirming the viability of proteome analysis in profiling AML.
format Article
author Almaiman, Amer Abdulrahman
Abdullah, Rasedee
Abdul, Ahmad
Allauddin, Zeenathul
Eid, Eltayeb E. M.
Saghir, Sultan Ayesh Mohammed
spellingShingle Almaiman, Amer Abdulrahman
Abdullah, Rasedee
Abdul, Ahmad
Allauddin, Zeenathul
Eid, Eltayeb E. M.
Saghir, Sultan Ayesh Mohammed
Proteomic profile of acute myeloid leukaemia: a review update
author_facet Almaiman, Amer Abdulrahman
Abdullah, Rasedee
Abdul, Ahmad
Allauddin, Zeenathul
Eid, Eltayeb E. M.
Saghir, Sultan Ayesh Mohammed
author_sort Almaiman, Amer Abdulrahman
title Proteomic profile of acute myeloid leukaemia: a review update
title_short Proteomic profile of acute myeloid leukaemia: a review update
title_full Proteomic profile of acute myeloid leukaemia: a review update
title_fullStr Proteomic profile of acute myeloid leukaemia: a review update
title_full_unstemmed Proteomic profile of acute myeloid leukaemia: a review update
title_sort proteomic profile of acute myeloid leukaemia: a review update
publisher Pharmacotherapy Group, Faculty of Pharmacy, University of Benin
publishDate 2016
url http://psasir.upm.edu.my/id/eprint/53696/1/Proteomic%20profile%20of%20acute%20myeloid%20leukaemia.pdf
http://psasir.upm.edu.my/id/eprint/53696/
https://www.ajol.info/index.php/tjpr/article/view/141960
_version_ 1643835462654099456
score 13.211869

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