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New synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route II)

A series of aminoanthraquinone derivatives were synthesized via two reaction steps. The starting material of 1,4-dihydroxyanthraquinone (1) was subjected toamination and the major product obtained was then further reacted under reduction, methylation and acylation separately to produce 2-(butylamino...

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Main Authors: Juhan, Siti Fadilah, Md Sukari, Mohd Aspollah, Syed Abdul Azziz, Saripah Salbiah, Wong, Chee Fah, Alimon, Hasimah, Mohd Nor, Siti Mariam
Format: Article
Language:English
Published: 2016
Online Access:http://psasir.upm.edu.my/id/eprint/53379/1/New%20synthesised%20aminoanthraquinone%20derivatives.pdf
http://psasir.upm.edu.my/id/eprint/53379/
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spelling my.upm.eprints.533792017-10-25T06:50:42Z http://psasir.upm.edu.my/id/eprint/53379/ New synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route II) Juhan, Siti Fadilah Md Sukari, Mohd Aspollah Syed Abdul Azziz, Saripah Salbiah Wong, Chee Fah Alimon, Hasimah Mohd Nor, Siti Mariam A series of aminoanthraquinone derivatives were synthesized via two reaction steps. The starting material of 1,4-dihydroxyanthraquinone (1) was subjected toamination and the major product obtained was then further reacted under reduction, methylation and acylation separately to produce 2-(butylamino)anthracene-1,4-dione (2), 2-(butylamino)-1-hydroxy-4-methoxyanthracene-9,10-dione (9), 2-(butylamino)-1,4-dimethoxyanthracene-9,10-dione (10), 3-(butylamino)-4-hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-yl-acetate (11), 2-(butylamino)-4-hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-yl-acetate (12) and 2-(butylamino)-9,10-dioxo-9,10-dihydroanthracene-1-yl-acetate (13). Aminoanthraquinone13 exhibitedstrong antimicrobial activities toward Methicillin-Resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Candida albicans and Escherichia coli with MIC values of 0.1, 0.1, 0.1 and 0.5 mg/mL respectively. Aminoanthraquinones 9, 10 and 13 showed strong cytotoxicity against both MCF-7 (IC50 2.0-11.0μg/mL)and Hep-G2 (IC50 1.1-14.0μg/mL) cell lines. 2016-01 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/53379/1/New%20synthesised%20aminoanthraquinone%20derivatives.pdf Juhan, Siti Fadilah and Md Sukari, Mohd Aspollah and Syed Abdul Azziz, Saripah Salbiah and Wong, Chee Fah and Alimon, Hasimah and Mohd Nor, Siti Mariam (2016) New synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route II). International Journal of Contemporary Applied Sciences, 3 (1). pp. 18-33. ISSN 2308-1365
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description A series of aminoanthraquinone derivatives were synthesized via two reaction steps. The starting material of 1,4-dihydroxyanthraquinone (1) was subjected toamination and the major product obtained was then further reacted under reduction, methylation and acylation separately to produce 2-(butylamino)anthracene-1,4-dione (2), 2-(butylamino)-1-hydroxy-4-methoxyanthracene-9,10-dione (9), 2-(butylamino)-1,4-dimethoxyanthracene-9,10-dione (10), 3-(butylamino)-4-hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-yl-acetate (11), 2-(butylamino)-4-hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-yl-acetate (12) and 2-(butylamino)-9,10-dioxo-9,10-dihydroanthracene-1-yl-acetate (13). Aminoanthraquinone13 exhibitedstrong antimicrobial activities toward Methicillin-Resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Candida albicans and Escherichia coli with MIC values of 0.1, 0.1, 0.1 and 0.5 mg/mL respectively. Aminoanthraquinones 9, 10 and 13 showed strong cytotoxicity against both MCF-7 (IC50 2.0-11.0μg/mL)and Hep-G2 (IC50 1.1-14.0μg/mL) cell lines.
format Article
author Juhan, Siti Fadilah
Md Sukari, Mohd Aspollah
Syed Abdul Azziz, Saripah Salbiah
Wong, Chee Fah
Alimon, Hasimah
Mohd Nor, Siti Mariam
spellingShingle Juhan, Siti Fadilah
Md Sukari, Mohd Aspollah
Syed Abdul Azziz, Saripah Salbiah
Wong, Chee Fah
Alimon, Hasimah
Mohd Nor, Siti Mariam
New synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route II)
author_facet Juhan, Siti Fadilah
Md Sukari, Mohd Aspollah
Syed Abdul Azziz, Saripah Salbiah
Wong, Chee Fah
Alimon, Hasimah
Mohd Nor, Siti Mariam
author_sort Juhan, Siti Fadilah
title New synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route II)
title_short New synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route II)
title_full New synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route II)
title_fullStr New synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route II)
title_full_unstemmed New synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route II)
title_sort new synthesised aminoanthraquinone derivatives and its antimicrobial and anticancer activities (route ii)
publishDate 2016
url http://psasir.upm.edu.my/id/eprint/53379/1/New%20synthesised%20aminoanthraquinone%20derivatives.pdf
http://psasir.upm.edu.my/id/eprint/53379/
_version_ 1643835378828836864
score 13.211869

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