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Isolation, structure elucidation, identification and quantitative analysis of 1'-acetoxychavicol (ACA) from the roots of Chlorophytum boriviliuanum (safed musli)

Chlorophytum borivilianum (safed musli) is a medicinally important plant. Its roots are being employed in folk medicine. Presently, the crude extract of C. borivilianum has been consumed for the treatment such as anti-diabetic, anti-aging, anti-oxidant, anti-ulcer and anti-inflammatory and previous...

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Main Authors: Chua, Bee Lin, Abdullah, Zunoliza, Pin, Kar Yong, Abdullah, Luqman Chuah, Choong, Thomas Shean Yaw, Yusof, Umi Kalsom
Format: Article
Language:English
Published: School of Engineering, Taylor’s University College 2017
Online Access:http://psasir.upm.edu.my/id/eprint/52032/1/Isolation%2C%20structure%20elucidation%2C%20identification%20and%20quantitative%20analysis%20of%201%27-acetoxychavicol%20%28ACA%29%20from%20the%20roots%20of%20Chlorophytum%20boriviliuanum%20%28safed%20musli%29.pdf
http://psasir.upm.edu.my/id/eprint/52032/
http://jestec.taylors.edu.my/V12Issue1.htm
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spelling my.upm.eprints.520322017-05-04T09:08:13Z http://psasir.upm.edu.my/id/eprint/52032/ Isolation, structure elucidation, identification and quantitative analysis of 1'-acetoxychavicol (ACA) from the roots of Chlorophytum boriviliuanum (safed musli) Chua, Bee Lin Abdullah, Zunoliza Pin, Kar Yong Abdullah, Luqman Chuah Choong, Thomas Shean Yaw Yusof, Umi Kalsom Chlorophytum borivilianum (safed musli) is a medicinally important plant. Its roots are being employed in folk medicine. Presently, the crude extract of C. borivilianum has been consumed for the treatment such as anti-diabetic, anti-aging, anti-oxidant, anti-ulcer and anti-inflammatory and previous studies have been carried out to further confirm these remarkable bioactivities of C. borivilianum. In this research, 1’-acetoxychavicol acetate (ACA) was isolated from the roots of C. borivilianum. The structure of ACA was elucidated based on the spectral data of 1H NMR, 13C NMR, DEPT, COSY, HMBC, HMQC and also based on the comparison with the previous literature data. ACA was isolated in an isocratic elution that eluted with hexane and ethyl acetate in the ratio of 10:0.25. In the HPLC analysis, the separation of the crude methanol extract was completed within 20 min and the retention time of ACA in the sample was 7.31 min. The regression equation of the calibration curve was developed and the correlation coefficient was found to be 0.991. This is the first report regarding the presence of ACA in C. borivilianum as well as its genus. For the first time, a high performance liquid chromatographic (HPLC) method with photodiode array detection was developed for the quantitative determination and identification of ACA. School of Engineering, Taylor’s University College 2017 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/52032/1/Isolation%2C%20structure%20elucidation%2C%20identification%20and%20quantitative%20analysis%20of%201%27-acetoxychavicol%20%28ACA%29%20from%20the%20roots%20of%20Chlorophytum%20boriviliuanum%20%28safed%20musli%29.pdf Chua, Bee Lin and Abdullah, Zunoliza and Pin, Kar Yong and Abdullah, Luqman Chuah and Choong, Thomas Shean Yaw and Yusof, Umi Kalsom (2017) Isolation, structure elucidation, identification and quantitative analysis of 1'-acetoxychavicol (ACA) from the roots of Chlorophytum boriviliuanum (safed musli). Journal of Engineering Science and Technology, 12 (1). pp. 198-213. ISSN 1823-4690 http://jestec.taylors.edu.my/V12Issue1.htm
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Chlorophytum borivilianum (safed musli) is a medicinally important plant. Its roots are being employed in folk medicine. Presently, the crude extract of C. borivilianum has been consumed for the treatment such as anti-diabetic, anti-aging, anti-oxidant, anti-ulcer and anti-inflammatory and previous studies have been carried out to further confirm these remarkable bioactivities of C. borivilianum. In this research, 1’-acetoxychavicol acetate (ACA) was isolated from the roots of C. borivilianum. The structure of ACA was elucidated based on the spectral data of 1H NMR, 13C NMR, DEPT, COSY, HMBC, HMQC and also based on the comparison with the previous literature data. ACA was isolated in an isocratic elution that eluted with hexane and ethyl acetate in the ratio of 10:0.25. In the HPLC analysis, the separation of the crude methanol extract was completed within 20 min and the retention time of ACA in the sample was 7.31 min. The regression equation of the calibration curve was developed and the correlation coefficient was found to be 0.991. This is the first report regarding the presence of ACA in C. borivilianum as well as its genus. For the first time, a high performance liquid chromatographic (HPLC) method with photodiode array detection was developed for the quantitative determination and identification of ACA.
format Article
author Chua, Bee Lin
Abdullah, Zunoliza
Pin, Kar Yong
Abdullah, Luqman Chuah
Choong, Thomas Shean Yaw
Yusof, Umi Kalsom
spellingShingle Chua, Bee Lin
Abdullah, Zunoliza
Pin, Kar Yong
Abdullah, Luqman Chuah
Choong, Thomas Shean Yaw
Yusof, Umi Kalsom
Isolation, structure elucidation, identification and quantitative analysis of 1'-acetoxychavicol (ACA) from the roots of Chlorophytum boriviliuanum (safed musli)
author_facet Chua, Bee Lin
Abdullah, Zunoliza
Pin, Kar Yong
Abdullah, Luqman Chuah
Choong, Thomas Shean Yaw
Yusof, Umi Kalsom
author_sort Chua, Bee Lin
title Isolation, structure elucidation, identification and quantitative analysis of 1'-acetoxychavicol (ACA) from the roots of Chlorophytum boriviliuanum (safed musli)
title_short Isolation, structure elucidation, identification and quantitative analysis of 1'-acetoxychavicol (ACA) from the roots of Chlorophytum boriviliuanum (safed musli)
title_full Isolation, structure elucidation, identification and quantitative analysis of 1'-acetoxychavicol (ACA) from the roots of Chlorophytum boriviliuanum (safed musli)
title_fullStr Isolation, structure elucidation, identification and quantitative analysis of 1'-acetoxychavicol (ACA) from the roots of Chlorophytum boriviliuanum (safed musli)
title_full_unstemmed Isolation, structure elucidation, identification and quantitative analysis of 1'-acetoxychavicol (ACA) from the roots of Chlorophytum boriviliuanum (safed musli)
title_sort isolation, structure elucidation, identification and quantitative analysis of 1'-acetoxychavicol (aca) from the roots of chlorophytum boriviliuanum (safed musli)
publisher School of Engineering, Taylor’s University College
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/52032/1/Isolation%2C%20structure%20elucidation%2C%20identification%20and%20quantitative%20analysis%20of%201%27-acetoxychavicol%20%28ACA%29%20from%20the%20roots%20of%20Chlorophytum%20boriviliuanum%20%28safed%20musli%29.pdf
http://psasir.upm.edu.my/id/eprint/52032/
http://jestec.taylors.edu.my/V12Issue1.htm
_version_ 1643835128505434112
score 13.211869

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