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Potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome

Introduction: Metabolic syndrome is associated with low-grade, chronic inflammation. Our study aimed to evaluate the effects of tocotrienols supplementation on cytokines and lipid profile in adults with metabolic syndrome. Methods: In a 16-week randomised, double-blind, placebo-controlled trial, 70...

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Main Authors: Heng, Kiang Soon, Abdul Rahman, Hejar, Stanslas, Johnson, Ooi, Cheow Peng, Loh, Su Peng
Format: Article
Language:English
Published: Nutrition Society of Malaysia 2015
Online Access:http://psasir.upm.edu.my/id/eprint/51979/1/Potential%20of%20mixed%20tocotrienol%20supplementation%20to%20reduce%20cholesterol%20and%20cytokines%20level%20in%20adults%20with%20metabolic%20syndrome.pdf
http://psasir.upm.edu.my/id/eprint/51979/
http://www.nutriweb.org.my/publications/mjn0021_2/9-%20Loh%20SP%20231-244.php
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spelling my.upm.eprints.519792017-05-04T04:44:28Z http://psasir.upm.edu.my/id/eprint/51979/ Potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome Heng, Kiang Soon Abdul Rahman, Hejar Stanslas, Johnson Ooi, Cheow Peng Loh, Su Peng Introduction: Metabolic syndrome is associated with low-grade, chronic inflammation. Our study aimed to evaluate the effects of tocotrienols supplementation on cytokines and lipid profile in adults with metabolic syndrome. Methods: In a 16-week randomised, double-blind, placebo-controlled trial, 70 adults with metabolic syndrome aged 20-60 years were randomly assigned to a mixed tocotrienols group (n=35) that received 400mg/day of mixed tocotrienols or a placebo group (n=35) that received capsules containing soy bean oil. At baseline, week 8 and week 16, anthropometric, body composition and blood pressure measurements were conducted. At baseline and week 16 only, serum levels of total cholesterol (TC) and high density lipoprotein (HDL)-cholesterol, plasma levels of fasting plasma glucose (FPG), interleukin-6 (IL-6), tumouxr necrosis factor- a (TNF-a), leptin, adiponectin and high sensitivity C-reactive protein were also determined. Changes in dietary intake and physical activity level between baseline, week 8 and week 16 were also assessed. Results: In the tocotrienols group, significant reductions from baseline were found in diastolic blood pressure (p=0.001), TC (p=0.008), LDL-cholesterol (p=0.022), HDL-cholesterol (p<0.001), IL-6 (p=0.024) and TNF-a (p=0.013) at week sixteen. However, the changes in the tocotrienols group were not significantly different from those of the placebo group. Conclusion: The 16-week mixed tocotrienols supplementation exerted potential beneficial effects on cytokines and lipid profile in adults with metabolic syndrome. The results might have been confounded by the physiological effects produced by the soy bean oil in the placebo capsule. Nutrition Society of Malaysia 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/51979/1/Potential%20of%20mixed%20tocotrienol%20supplementation%20to%20reduce%20cholesterol%20and%20cytokines%20level%20in%20adults%20with%20metabolic%20syndrome.pdf Heng, Kiang Soon and Abdul Rahman, Hejar and Stanslas, Johnson and Ooi, Cheow Peng and Loh, Su Peng (2015) Potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome. Malaysian Journal of Nutrition, 21 (2). pp. 231-243. ISSN 1394-035X http://www.nutriweb.org.my/publications/mjn0021_2/9-%20Loh%20SP%20231-244.php
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Introduction: Metabolic syndrome is associated with low-grade, chronic inflammation. Our study aimed to evaluate the effects of tocotrienols supplementation on cytokines and lipid profile in adults with metabolic syndrome. Methods: In a 16-week randomised, double-blind, placebo-controlled trial, 70 adults with metabolic syndrome aged 20-60 years were randomly assigned to a mixed tocotrienols group (n=35) that received 400mg/day of mixed tocotrienols or a placebo group (n=35) that received capsules containing soy bean oil. At baseline, week 8 and week 16, anthropometric, body composition and blood pressure measurements were conducted. At baseline and week 16 only, serum levels of total cholesterol (TC) and high density lipoprotein (HDL)-cholesterol, plasma levels of fasting plasma glucose (FPG), interleukin-6 (IL-6), tumouxr necrosis factor- a (TNF-a), leptin, adiponectin and high sensitivity C-reactive protein were also determined. Changes in dietary intake and physical activity level between baseline, week 8 and week 16 were also assessed. Results: In the tocotrienols group, significant reductions from baseline were found in diastolic blood pressure (p=0.001), TC (p=0.008), LDL-cholesterol (p=0.022), HDL-cholesterol (p<0.001), IL-6 (p=0.024) and TNF-a (p=0.013) at week sixteen. However, the changes in the tocotrienols group were not significantly different from those of the placebo group. Conclusion: The 16-week mixed tocotrienols supplementation exerted potential beneficial effects on cytokines and lipid profile in adults with metabolic syndrome. The results might have been confounded by the physiological effects produced by the soy bean oil in the placebo capsule.
format Article
author Heng, Kiang Soon
Abdul Rahman, Hejar
Stanslas, Johnson
Ooi, Cheow Peng
Loh, Su Peng
spellingShingle Heng, Kiang Soon
Abdul Rahman, Hejar
Stanslas, Johnson
Ooi, Cheow Peng
Loh, Su Peng
Potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome
author_facet Heng, Kiang Soon
Abdul Rahman, Hejar
Stanslas, Johnson
Ooi, Cheow Peng
Loh, Su Peng
author_sort Heng, Kiang Soon
title Potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome
title_short Potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome
title_full Potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome
title_fullStr Potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome
title_full_unstemmed Potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome
title_sort potential of mixed tocotrienol supplementation to reduce cholesterol and cytokines level in adults with metabolic syndrome
publisher Nutrition Society of Malaysia
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/51979/1/Potential%20of%20mixed%20tocotrienol%20supplementation%20to%20reduce%20cholesterol%20and%20cytokines%20level%20in%20adults%20with%20metabolic%20syndrome.pdf
http://psasir.upm.edu.my/id/eprint/51979/
http://www.nutriweb.org.my/publications/mjn0021_2/9-%20Loh%20SP%20231-244.php
_version_ 1643835112961343488
score 13.211869

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