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Comparative study of antioxidant level and activity from leaf extracts of Annona muricata Linn obtained from different locations

Annona muricata Linn possesses an anti-tumorigenic effect towards cancer. Several of its bioactive components have already been assessed in previous findings. However, none of the previous studies actually addressed the important consideration of the association between cultivation area of this medi...

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Main Authors: Syed Najmuddin, Syed Umar Faruq, Mohammed Alitheen, Noorjahan Banu, Hamid, Muhajir, Nik Abd Rahman, Nik Mohd Afizan
Format: Article
Language:English
Published: Universiti Putra Malaysia Press 2017
Online Access:http://psasir.upm.edu.my/id/eprint/51638/1/9-JTAS-087-2016-5thProof.pdf
http://psasir.upm.edu.my/id/eprint/51638/
http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2040%20(1)%20Feb.%202017/9-JTAS-087-2016-5thProof.pdf
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spelling my.upm.eprints.516382017-04-05T05:28:40Z http://psasir.upm.edu.my/id/eprint/51638/ Comparative study of antioxidant level and activity from leaf extracts of Annona muricata Linn obtained from different locations Syed Najmuddin, Syed Umar Faruq Mohammed Alitheen, Noorjahan Banu Hamid, Muhajir Nik Abd Rahman, Nik Mohd Afizan Annona muricata Linn possesses an anti-tumorigenic effect towards cancer. Several of its bioactive components have already been assessed in previous findings. However, none of the previous studies actually addressed the important consideration of the association between cultivation area of this medicinal plant and its bioactive compounds/antioxidants. In this study, the antioxidant level and antioxidant activity of 19 Annona muricata collected from different locations were evaluated by phenolic and flavonoid assays together with Oxygen Radical Absorbance Capacity (ORAC), Ferric Reducing Ability of Plasma (FRAP) and 1,1-Diphenyl-2-picryl-hydrazyl (DPPH) assays. M1 was found to have an attractive antioxidant profile as it had the highest content of phenolics (73.2 µg/mL GAE) and flavonoids (191.4 µg/mL CE) and also the highest antioxidant capacity in ORAC assay (254.7 µM). Additionally, it had a favourably high ferric ion reducing capacity (15.55 µM Fe2+/µg) and the best free DPPH-radical scavenging activity (IC50=143.5 µg/mL). On the contrary, R1 showed the lowest level of phenolics with a GAE value of 21.92 µg/mL, ranked second lowest in flavonoid content (65.42 µg/mL CE), and it had the least antioxidant capacity in ORAC (94.66 µM), FRAP (4.17 µM Fe2+/µg) and DPPH assays (1597 µg/mL), making it the least desirable antioxidant source. Based on this finding, it was concluded that Annona muricata Linn had varied antioxidant levels and activity regarding its cultivation area; hence, it would be a guide in the selection of potential candidates for natural antioxidants in phytopharmacy. Universiti Putra Malaysia Press 2017 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/51638/1/9-JTAS-087-2016-5thProof.pdf Syed Najmuddin, Syed Umar Faruq and Mohammed Alitheen, Noorjahan Banu and Hamid, Muhajir and Nik Abd Rahman, Nik Mohd Afizan (2017) Comparative study of antioxidant level and activity from leaf extracts of Annona muricata Linn obtained from different locations. Pertanika Journal of Tropical Agricultural Science, 40 (1). pp. 119-130. ISSN 1511-3701; ESSN: 2231-8542 http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2040%20(1)%20Feb.%202017/9-JTAS-087-2016-5thProof.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Annona muricata Linn possesses an anti-tumorigenic effect towards cancer. Several of its bioactive components have already been assessed in previous findings. However, none of the previous studies actually addressed the important consideration of the association between cultivation area of this medicinal plant and its bioactive compounds/antioxidants. In this study, the antioxidant level and antioxidant activity of 19 Annona muricata collected from different locations were evaluated by phenolic and flavonoid assays together with Oxygen Radical Absorbance Capacity (ORAC), Ferric Reducing Ability of Plasma (FRAP) and 1,1-Diphenyl-2-picryl-hydrazyl (DPPH) assays. M1 was found to have an attractive antioxidant profile as it had the highest content of phenolics (73.2 µg/mL GAE) and flavonoids (191.4 µg/mL CE) and also the highest antioxidant capacity in ORAC assay (254.7 µM). Additionally, it had a favourably high ferric ion reducing capacity (15.55 µM Fe2+/µg) and the best free DPPH-radical scavenging activity (IC50=143.5 µg/mL). On the contrary, R1 showed the lowest level of phenolics with a GAE value of 21.92 µg/mL, ranked second lowest in flavonoid content (65.42 µg/mL CE), and it had the least antioxidant capacity in ORAC (94.66 µM), FRAP (4.17 µM Fe2+/µg) and DPPH assays (1597 µg/mL), making it the least desirable antioxidant source. Based on this finding, it was concluded that Annona muricata Linn had varied antioxidant levels and activity regarding its cultivation area; hence, it would be a guide in the selection of potential candidates for natural antioxidants in phytopharmacy.
format Article
author Syed Najmuddin, Syed Umar Faruq
Mohammed Alitheen, Noorjahan Banu
Hamid, Muhajir
Nik Abd Rahman, Nik Mohd Afizan
spellingShingle Syed Najmuddin, Syed Umar Faruq
Mohammed Alitheen, Noorjahan Banu
Hamid, Muhajir
Nik Abd Rahman, Nik Mohd Afizan
Comparative study of antioxidant level and activity from leaf extracts of Annona muricata Linn obtained from different locations
author_facet Syed Najmuddin, Syed Umar Faruq
Mohammed Alitheen, Noorjahan Banu
Hamid, Muhajir
Nik Abd Rahman, Nik Mohd Afizan
author_sort Syed Najmuddin, Syed Umar Faruq
title Comparative study of antioxidant level and activity from leaf extracts of Annona muricata Linn obtained from different locations
title_short Comparative study of antioxidant level and activity from leaf extracts of Annona muricata Linn obtained from different locations
title_full Comparative study of antioxidant level and activity from leaf extracts of Annona muricata Linn obtained from different locations
title_fullStr Comparative study of antioxidant level and activity from leaf extracts of Annona muricata Linn obtained from different locations
title_full_unstemmed Comparative study of antioxidant level and activity from leaf extracts of Annona muricata Linn obtained from different locations
title_sort comparative study of antioxidant level and activity from leaf extracts of annona muricata linn obtained from different locations
publisher Universiti Putra Malaysia Press
publishDate 2017
url http://psasir.upm.edu.my/id/eprint/51638/1/9-JTAS-087-2016-5thProof.pdf
http://psasir.upm.edu.my/id/eprint/51638/
http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2040%20(1)%20Feb.%202017/9-JTAS-087-2016-5thProof.pdf
_version_ 1643835012408147968
score 13.211869

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