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Acute toxicological assessment of seashore mangosteen (Garcinia hombroniana) aqueous extract

Garcinia hombroniana has been used in Malay traditional medicine to treat various disorders such as abdominal pain and gonorrhea, and little is known about its toxicological properties. This study investigated the acute toxicological effects of the plant’s leaves aqueous extract using theoral acute...

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Main Authors:	Othman, Dyary Hiewa, Abdul Kadir, Arifah, Kumar Sharma, Reuben Sunil, Abdullah, Rasedee, Md. Sukari, Mohd Aspollah, Zakaria, Zainul Amiruddin, Ahmad, Zuraini, Abdullah, Muhammad Nazrul Hakim
Format:	Article
Language:	English
Published:	Veterinary Association Malaysia 2016
Online Access:	http://psasir.upm.edu.my/id/eprint/50398/1/2016-Issue-2_Dr-Arifah.pdf http://psasir.upm.edu.my/id/eprint/50398/ http://jvm.vam.org.my/wp-content/uploads/2016/12/2016-Issue-2_Dr-Arifah.pdf
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spelling	my.upm.eprints.503982017-02-28T05:37:50Z http://psasir.upm.edu.my/id/eprint/50398/ Acute toxicological assessment of seashore mangosteen (Garcinia hombroniana) aqueous extract Othman, Dyary Hiewa Abdul Kadir, Arifah Kumar Sharma, Reuben Sunil Abdullah, Rasedee Md. Sukari, Mohd Aspollah Zakaria, Zainul Amiruddin Ahmad, Zuraini Abdullah, Muhammad Nazrul Hakim Garcinia hombroniana has been used in Malay traditional medicine to treat various disorders such as abdominal pain and gonorrhea, and little is known about its toxicological properties. This study investigated the acute toxicological effects of the plant’s leaves aqueous extract using theoral acute toxic class (ATC) method. Twenty-four female Sprague-Dawley rats were divided into T1, T2, T3 and control groups. The T1, T2 and T3 rats administered a single oral dose of 300, 2000 and 5000 mg/kg of G. hombroniana leaves aqueous extract, respectively. The animals were checked daily for abnormal clinical signs and mortality rate for 14 days. The body weight, daily food and water consumption were recorded. The haematological and biochemical parameters of blood as well as relative organ weight and tissues histology such as heart, kidney, liver and spleen were evaluated. Results have shown significantly decreased (p< 0.05) food and water consumption in T2 and T3 rats, which returned to normal after 72 hr post administration. No significant differences (p≥0.05) in the haematological and serum biochemical parameters in the treated rat groups, compared to the untreated control animals. An increase in the relative weight of spleen was noticed in T3 animals. Congestion of the splenic, hepatic, cardiac and renal tissues was seen in T2 and T3 rats. The oral LD50 was higher than 5000 mg/kg of body weight. Thus, it can be concluded that G. hombroniana aqueous extract shows little toxicity in the laboratory rats and the therapeutic potentials should be further investigated. Veterinary Association Malaysia 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/50398/1/2016-Issue-2_Dr-Arifah.pdf Othman, Dyary Hiewa and Abdul Kadir, Arifah and Kumar Sharma, Reuben Sunil and Abdullah, Rasedee and Md. Sukari, Mohd Aspollah and Zakaria, Zainul Amiruddin and Ahmad, Zuraini and Abdullah, Muhammad Nazrul Hakim (2016) Acute toxicological assessment of seashore mangosteen (Garcinia hombroniana) aqueous extract. Jurnal Veterinar Malaysia, 28 (2). pp. 4-11. ISSN 9128-2506 http://jvm.vam.org.my/wp-content/uploads/2016/12/2016-Issue-2_Dr-Arifah.pdf
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
language	English
description	Garcinia hombroniana has been used in Malay traditional medicine to treat various disorders such as abdominal pain and gonorrhea, and little is known about its toxicological properties. This study investigated the acute toxicological effects of the plant’s leaves aqueous extract using theoral acute toxic class (ATC) method. Twenty-four female Sprague-Dawley rats were divided into T1, T2, T3 and control groups. The T1, T2 and T3 rats administered a single oral dose of 300, 2000 and 5000 mg/kg of G. hombroniana leaves aqueous extract, respectively. The animals were checked daily for abnormal clinical signs and mortality rate for 14 days. The body weight, daily food and water consumption were recorded. The haematological and biochemical parameters of blood as well as relative organ weight and tissues histology such as heart, kidney, liver and spleen were evaluated. Results have shown significantly decreased (p< 0.05) food and water consumption in T2 and T3 rats, which returned to normal after 72 hr post administration. No significant differences (p≥0.05) in the haematological and serum biochemical parameters in the treated rat groups, compared to the untreated control animals. An increase in the relative weight of spleen was noticed in T3 animals. Congestion of the splenic, hepatic, cardiac and renal tissues was seen in T2 and T3 rats. The oral LD50 was higher than 5000 mg/kg of body weight. Thus, it can be concluded that G. hombroniana aqueous extract shows little toxicity in the laboratory rats and the therapeutic potentials should be further investigated.
format	Article
author	Othman, Dyary Hiewa Abdul Kadir, Arifah Kumar Sharma, Reuben Sunil Abdullah, Rasedee Md. Sukari, Mohd Aspollah Zakaria, Zainul Amiruddin Ahmad, Zuraini Abdullah, Muhammad Nazrul Hakim
spellingShingle	Othman, Dyary Hiewa Abdul Kadir, Arifah Kumar Sharma, Reuben Sunil Abdullah, Rasedee Md. Sukari, Mohd Aspollah Zakaria, Zainul Amiruddin Ahmad, Zuraini Abdullah, Muhammad Nazrul Hakim Acute toxicological assessment of seashore mangosteen (Garcinia hombroniana) aqueous extract
author_facet	Othman, Dyary Hiewa Abdul Kadir, Arifah Kumar Sharma, Reuben Sunil Abdullah, Rasedee Md. Sukari, Mohd Aspollah Zakaria, Zainul Amiruddin Ahmad, Zuraini Abdullah, Muhammad Nazrul Hakim
author_sort	Othman, Dyary Hiewa
title	Acute toxicological assessment of seashore mangosteen (Garcinia hombroniana) aqueous extract
title_short	Acute toxicological assessment of seashore mangosteen (Garcinia hombroniana) aqueous extract
title_full	Acute toxicological assessment of seashore mangosteen (Garcinia hombroniana) aqueous extract
title_fullStr	Acute toxicological assessment of seashore mangosteen (Garcinia hombroniana) aqueous extract
title_full_unstemmed	Acute toxicological assessment of seashore mangosteen (Garcinia hombroniana) aqueous extract
title_sort	acute toxicological assessment of seashore mangosteen (garcinia hombroniana) aqueous extract
publisher	Veterinary Association Malaysia
publishDate	2016
url	http://psasir.upm.edu.my/id/eprint/50398/1/2016-Issue-2_Dr-Arifah.pdf http://psasir.upm.edu.my/id/eprint/50398/ http://jvm.vam.org.my/wp-content/uploads/2016/12/2016-Issue-2_Dr-Arifah.pdf
_version_	1643834651193638912
score	13.211869

Acute toxicological assessment of seashore mangosteen (Garcinia hombroniana) aqueous extract

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