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Hypolipidemic activity of an aqueous extract of Morinda citrifolia fruit in normal and streptozotocin-induced diabetic rats

This study was undertaken to investigate the hypolipidemic activity of Morinda citrifolia fruit extract. Aqueous extract of M. citrifolia in concentrations ranging from 0.25 g/kg (low dose), 0.50 g/kg (medium dose) and 1.00 g/kg (high dose) were orally administered on streptozotocin-induced diabetic...

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Main Authors: Hassan, Hadijah, Mohd Yatim, Ayub, Hambali, Zarida, Ahamad, Normah
Format: Article
Language:English
Published: Malaysian Agricultural Research and Development Institute (MARDI) 2008
Online Access:http://psasir.upm.edu.my/id/eprint/48887/1/Hypolipidemic%20activity%20of%20an%20aqueous%20extract%20of%20Morinda%20citrifolia%20fruit%20in%20normal%20and%20streptozotocin-induced%20diabetic%20rats.pdf
http://psasir.upm.edu.my/id/eprint/48887/
http://ejtafs.mardi.gov.my/index.php/publication/issues/archive/37-2008/volume-36-no1/108-360109
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spelling my.upm.eprints.488872016-12-29T09:48:30Z http://psasir.upm.edu.my/id/eprint/48887/ Hypolipidemic activity of an aqueous extract of Morinda citrifolia fruit in normal and streptozotocin-induced diabetic rats Hassan, Hadijah Mohd Yatim, Ayub Hambali, Zarida Ahamad, Normah This study was undertaken to investigate the hypolipidemic activity of Morinda citrifolia fruit extract. Aqueous extract of M. citrifolia in concentrations ranging from 0.25 g/kg (low dose), 0.50 g/kg (medium dose) and 1.00 g/kg (high dose) were orally administered on streptozotocin-induced diabetic rats for 6 weeks. The hypolipidemic effect of M. citrifolia extract in rats was determined by measuring the total lipid, total cholesterol and triglyceride concentrations in blood (plasma) and liver tissue. The administration of medium dose of M. citrifolia extract had significantly (p <0.05) reduced the cholesterol content in blood and liver of normal rats as compared to the normal control rats. For the diabetic rats, the administration of medium and high doses of M. citrifolia extracts successfully reduced the plasma triglyceride level significantly (p <0.05) as compared to diabetic control rats. The concentration of triglyceride and total lipid in the liver were also decreased significantly (p <0.05) in the diabetic rats which had received high dose of M. citrifolia extract as compared to control rats. Results showed that M. citrifolia exhibits the potential in lowering the concentration of certain lipid components in blood and tissue of experimental rats. Malaysian Agricultural Research and Development Institute (MARDI) 2008 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/48887/1/Hypolipidemic%20activity%20of%20an%20aqueous%20extract%20of%20Morinda%20citrifolia%20fruit%20in%20normal%20and%20streptozotocin-induced%20diabetic%20rats.pdf Hassan, Hadijah and Mohd Yatim, Ayub and Hambali, Zarida and Ahamad, Normah (2008) Hypolipidemic activity of an aqueous extract of Morinda citrifolia fruit in normal and streptozotocin-induced diabetic rats. Journal of Tropical Agriculture and Food Science, 36 (1). pp. 77-85. ISSN 1394-9829; ESSN: 2289-9650 http://ejtafs.mardi.gov.my/index.php/publication/issues/archive/37-2008/volume-36-no1/108-360109
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description This study was undertaken to investigate the hypolipidemic activity of Morinda citrifolia fruit extract. Aqueous extract of M. citrifolia in concentrations ranging from 0.25 g/kg (low dose), 0.50 g/kg (medium dose) and 1.00 g/kg (high dose) were orally administered on streptozotocin-induced diabetic rats for 6 weeks. The hypolipidemic effect of M. citrifolia extract in rats was determined by measuring the total lipid, total cholesterol and triglyceride concentrations in blood (plasma) and liver tissue. The administration of medium dose of M. citrifolia extract had significantly (p <0.05) reduced the cholesterol content in blood and liver of normal rats as compared to the normal control rats. For the diabetic rats, the administration of medium and high doses of M. citrifolia extracts successfully reduced the plasma triglyceride level significantly (p <0.05) as compared to diabetic control rats. The concentration of triglyceride and total lipid in the liver were also decreased significantly (p <0.05) in the diabetic rats which had received high dose of M. citrifolia extract as compared to control rats. Results showed that M. citrifolia exhibits the potential in lowering the concentration of certain lipid components in blood and tissue of experimental rats.
format Article
author Hassan, Hadijah
Mohd Yatim, Ayub
Hambali, Zarida
Ahamad, Normah
spellingShingle Hassan, Hadijah
Mohd Yatim, Ayub
Hambali, Zarida
Ahamad, Normah
Hypolipidemic activity of an aqueous extract of Morinda citrifolia fruit in normal and streptozotocin-induced diabetic rats
author_facet Hassan, Hadijah
Mohd Yatim, Ayub
Hambali, Zarida
Ahamad, Normah
author_sort Hassan, Hadijah
title Hypolipidemic activity of an aqueous extract of Morinda citrifolia fruit in normal and streptozotocin-induced diabetic rats
title_short Hypolipidemic activity of an aqueous extract of Morinda citrifolia fruit in normal and streptozotocin-induced diabetic rats
title_full Hypolipidemic activity of an aqueous extract of Morinda citrifolia fruit in normal and streptozotocin-induced diabetic rats
title_fullStr Hypolipidemic activity of an aqueous extract of Morinda citrifolia fruit in normal and streptozotocin-induced diabetic rats
title_full_unstemmed Hypolipidemic activity of an aqueous extract of Morinda citrifolia fruit in normal and streptozotocin-induced diabetic rats
title_sort hypolipidemic activity of an aqueous extract of morinda citrifolia fruit in normal and streptozotocin-induced diabetic rats
publisher Malaysian Agricultural Research and Development Institute (MARDI)
publishDate 2008
url http://psasir.upm.edu.my/id/eprint/48887/1/Hypolipidemic%20activity%20of%20an%20aqueous%20extract%20of%20Morinda%20citrifolia%20fruit%20in%20normal%20and%20streptozotocin-induced%20diabetic%20rats.pdf
http://psasir.upm.edu.my/id/eprint/48887/
http://ejtafs.mardi.gov.my/index.php/publication/issues/archive/37-2008/volume-36-no1/108-360109
_version_ 1643834306561310720
score 13.211869

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