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Effects of Centella asiatica extract and powder on hydrogen peroxide-treated Sprague-Dawley rats

A study was conducted to investigate the effect of Centella asiatica extract and powder on dietary intake, body weight, organ weights and blood lipid peroxidation of hydrogen peroxide (H2O2)-treated male Sprague-Dawley rats. The experimental rats were fed with 0.3% (w/w) C. asiatica extract, 1.5% (w...

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Main Authors: Hussin, Mahanom, Abdul Hamid, Azizah, Mohamed, Suhaila, Saari, Nazamid, Ismail, Maznah, Bejo, Mohd Hair
Format: Article
Language:English
Published: Malaysian Agricultural Research and Development Institute (MARDI) 2011
Online Access:http://psasir.upm.edu.my/id/eprint/48884/1/Effects%20of%20Centella%20asiatica%20extract%20and%20powder%20on%20hydrogen%20peroxide-treated%2045%20Sprague-Dawley%20rats.pdf
http://psasir.upm.edu.my/id/eprint/48884/
http://ejtafs.mardi.gov.my/index.php/publication/issues/archive/25-2011/volume-39-no1/32-390106
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spelling my.upm.eprints.488842016-12-29T09:34:38Z http://psasir.upm.edu.my/id/eprint/48884/ Effects of Centella asiatica extract and powder on hydrogen peroxide-treated Sprague-Dawley rats Hussin, Mahanom Abdul Hamid, Azizah Mohamed, Suhaila Saari, Nazamid Ismail, Maznah Bejo, Mohd Hair A study was conducted to investigate the effect of Centella asiatica extract and powder on dietary intake, body weight, organ weights and blood lipid peroxidation of hydrogen peroxide (H2O2)-treated male Sprague-Dawley rats. The experimental rats were fed with 0.3% (w/w) C. asiatica extract, 1.5% (w/w) C. asiatica powder, 5.0% (w/w) C. asiatica powder and 0.3% (w/w) a-tocopherol for 6 weeks. To induce oxidative stress, the rats were given drinking water spiked with 0.03% (v/v) H2O2. The amount of dietary intake, organ and body weight, and malonaldehyde (MDA) level throughout the study were monitored. Histopathological examination of selected organs was done at the end of the study. The results showed that MDA level was significantly (p <0.05) higher in the normal rats compared to treated rats. Dietary supplementation of C. asiatica (extract and powder) and a-tocopherol significantly (p <0.05) reduced lipid peroxidation in the experimental rats. However, there were no significant differences in dietary intake and histopathology observations of the organs of the rats. Malaysian Agricultural Research and Development Institute (MARDI) 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/48884/1/Effects%20of%20Centella%20asiatica%20extract%20and%20powder%20on%20hydrogen%20peroxide-treated%2045%20Sprague-Dawley%20rats.pdf Hussin, Mahanom and Abdul Hamid, Azizah and Mohamed, Suhaila and Saari, Nazamid and Ismail, Maznah and Bejo, Mohd Hair (2011) Effects of Centella asiatica extract and powder on hydrogen peroxide-treated Sprague-Dawley rats. Journal of Tropical Agriculture and Food Science, 39 (1). pp. 1-10. ISSN 1394-9829; ESSN: 2289-9650 http://ejtafs.mardi.gov.my/index.php/publication/issues/archive/25-2011/volume-39-no1/32-390106
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description A study was conducted to investigate the effect of Centella asiatica extract and powder on dietary intake, body weight, organ weights and blood lipid peroxidation of hydrogen peroxide (H2O2)-treated male Sprague-Dawley rats. The experimental rats were fed with 0.3% (w/w) C. asiatica extract, 1.5% (w/w) C. asiatica powder, 5.0% (w/w) C. asiatica powder and 0.3% (w/w) a-tocopherol for 6 weeks. To induce oxidative stress, the rats were given drinking water spiked with 0.03% (v/v) H2O2. The amount of dietary intake, organ and body weight, and malonaldehyde (MDA) level throughout the study were monitored. Histopathological examination of selected organs was done at the end of the study. The results showed that MDA level was significantly (p <0.05) higher in the normal rats compared to treated rats. Dietary supplementation of C. asiatica (extract and powder) and a-tocopherol significantly (p <0.05) reduced lipid peroxidation in the experimental rats. However, there were no significant differences in dietary intake and histopathology observations of the organs of the rats.
format Article
author Hussin, Mahanom
Abdul Hamid, Azizah
Mohamed, Suhaila
Saari, Nazamid
Ismail, Maznah
Bejo, Mohd Hair
spellingShingle Hussin, Mahanom
Abdul Hamid, Azizah
Mohamed, Suhaila
Saari, Nazamid
Ismail, Maznah
Bejo, Mohd Hair
Effects of Centella asiatica extract and powder on hydrogen peroxide-treated Sprague-Dawley rats
author_facet Hussin, Mahanom
Abdul Hamid, Azizah
Mohamed, Suhaila
Saari, Nazamid
Ismail, Maznah
Bejo, Mohd Hair
author_sort Hussin, Mahanom
title Effects of Centella asiatica extract and powder on hydrogen peroxide-treated Sprague-Dawley rats
title_short Effects of Centella asiatica extract and powder on hydrogen peroxide-treated Sprague-Dawley rats
title_full Effects of Centella asiatica extract and powder on hydrogen peroxide-treated Sprague-Dawley rats
title_fullStr Effects of Centella asiatica extract and powder on hydrogen peroxide-treated Sprague-Dawley rats
title_full_unstemmed Effects of Centella asiatica extract and powder on hydrogen peroxide-treated Sprague-Dawley rats
title_sort effects of centella asiatica extract and powder on hydrogen peroxide-treated sprague-dawley rats
publisher Malaysian Agricultural Research and Development Institute (MARDI)
publishDate 2011
url http://psasir.upm.edu.my/id/eprint/48884/1/Effects%20of%20Centella%20asiatica%20extract%20and%20powder%20on%20hydrogen%20peroxide-treated%2045%20Sprague-Dawley%20rats.pdf
http://psasir.upm.edu.my/id/eprint/48884/
http://ejtafs.mardi.gov.my/index.php/publication/issues/archive/25-2011/volume-39-no1/32-390106
_version_ 1643834305674215424
score 13.211869

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