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Fractional exhaled nitric oxide (FeNO) among office workers in an academic institution, Malaysia – associations with asthma, allergies and office environment

Objective: There are few studies on fractional exhaled nitric oxide (FeNO) and respiratory symptoms among adults in tropical areas. The aim was to study associations between FeNO and selected personal factors, respiratory symptoms, allergies, office characteristics and indoor office exposures among...

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Main Authors: Lim, Fang Lee, Hashim, Zailina, Md Said, Salmiah, Than, Leslie Thian Lung, Hashim, Jamal Hisham, Norback, Dan
Format: Article
Language:English
Published: Taylor & Francis 2016
Online Access:http://psasir.upm.edu.my/id/eprint/47514/1/Fractional%20exhaled%20nitric%20oxide%20%28FeNO%29%20among%20office%20workers%20in%20an%20academic%20institution%2C%20Malaysia%20%E2%80%93%20associations%20with%20asthma%2C%20allergies%20and%20office%20environment.pdf
http://psasir.upm.edu.my/id/eprint/47514/
http://www.tandfonline.com/doi/abs/10.3109/02770903.2015.1077861?journalCode=ijas20
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spelling my.upm.eprints.475142016-05-20T02:59:40Z http://psasir.upm.edu.my/id/eprint/47514/ Fractional exhaled nitric oxide (FeNO) among office workers in an academic institution, Malaysia – associations with asthma, allergies and office environment Lim, Fang Lee Hashim, Zailina Md Said, Salmiah Than, Leslie Thian Lung Hashim, Jamal Hisham Norback, Dan Objective: There are few studies on fractional exhaled nitric oxide (FeNO) and respiratory symptoms among adults in tropical areas. The aim was to study associations between FeNO and selected personal factors, respiratory symptoms, allergies, office characteristics and indoor office exposures among office workers (n = 460) from a university in Malaysia. Methods: Information on health was collected by a questionnaire, skin prick test and FeNO measurement. Temperature, relative air humidity, carbon monoxide and carbon dioxide were measured in the offices. Settled dust was vacuumed in the offices and analyzed for endotoxin, (1,3)-β-glucan and house dust mites allergens, namely Dermatophagoides pteronyssinus (Der p 1) and Dermatophagoides farinae (Der f 1). Two-level linear mixed models and multiple logistic regression were used to analyze the associations. Results: One-fourth (25.9%) of the office workers had elevated FeNO level (≥25 ppb) and 61.5% had HDM, cat, seafood or pollen allergy. Male gender (p < 0.001), current smoking (p = 0.037), height (p < 0.001) and atopy (p < 0.001) were associated with FeNO. The amount of vacuumed dust was associated with FeNO among atopic subjects (p = 0.009). Asthma and rhinitis symptoms were associated with FeNO (p < 0.05), especially among atopic subjects. In particular, a combination of atopy and elevated FeNO were associated with doctor-diagnosed asthma (p < 0.001), rhinitis (p < 0.001) and airway symptoms last 12 months (p < 0.001). Conclusion: Gender, smoking, height and atopy are important risk factors for elevated FeNO levels. A combination of allergy testing and FeNO measurement could be useful in respiratory illness epidemiology studies and patient investigations in tropical areas. Taylor & Francis 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/47514/1/Fractional%20exhaled%20nitric%20oxide%20%28FeNO%29%20among%20office%20workers%20in%20an%20academic%20institution%2C%20Malaysia%20%E2%80%93%20associations%20with%20asthma%2C%20allergies%20and%20office%20environment.pdf Lim, Fang Lee and Hashim, Zailina and Md Said, Salmiah and Than, Leslie Thian Lung and Hashim, Jamal Hisham and Norback, Dan (2016) Fractional exhaled nitric oxide (FeNO) among office workers in an academic institution, Malaysia – associations with asthma, allergies and office environment. Journal of Asthma, 53 (2). pp. 170-178. ISSN 0277-0903; ESSN: 1532-4303 http://www.tandfonline.com/doi/abs/10.3109/02770903.2015.1077861?journalCode=ijas20 10.3109/02770903.2015.1077861
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Objective: There are few studies on fractional exhaled nitric oxide (FeNO) and respiratory symptoms among adults in tropical areas. The aim was to study associations between FeNO and selected personal factors, respiratory symptoms, allergies, office characteristics and indoor office exposures among office workers (n = 460) from a university in Malaysia. Methods: Information on health was collected by a questionnaire, skin prick test and FeNO measurement. Temperature, relative air humidity, carbon monoxide and carbon dioxide were measured in the offices. Settled dust was vacuumed in the offices and analyzed for endotoxin, (1,3)-β-glucan and house dust mites allergens, namely Dermatophagoides pteronyssinus (Der p 1) and Dermatophagoides farinae (Der f 1). Two-level linear mixed models and multiple logistic regression were used to analyze the associations. Results: One-fourth (25.9%) of the office workers had elevated FeNO level (≥25 ppb) and 61.5% had HDM, cat, seafood or pollen allergy. Male gender (p < 0.001), current smoking (p = 0.037), height (p < 0.001) and atopy (p < 0.001) were associated with FeNO. The amount of vacuumed dust was associated with FeNO among atopic subjects (p = 0.009). Asthma and rhinitis symptoms were associated with FeNO (p < 0.05), especially among atopic subjects. In particular, a combination of atopy and elevated FeNO were associated with doctor-diagnosed asthma (p < 0.001), rhinitis (p < 0.001) and airway symptoms last 12 months (p < 0.001). Conclusion: Gender, smoking, height and atopy are important risk factors for elevated FeNO levels. A combination of allergy testing and FeNO measurement could be useful in respiratory illness epidemiology studies and patient investigations in tropical areas.
format Article
author Lim, Fang Lee
Hashim, Zailina
Md Said, Salmiah
Than, Leslie Thian Lung
Hashim, Jamal Hisham
Norback, Dan
spellingShingle Lim, Fang Lee
Hashim, Zailina
Md Said, Salmiah
Than, Leslie Thian Lung
Hashim, Jamal Hisham
Norback, Dan
Fractional exhaled nitric oxide (FeNO) among office workers in an academic institution, Malaysia – associations with asthma, allergies and office environment
author_facet Lim, Fang Lee
Hashim, Zailina
Md Said, Salmiah
Than, Leslie Thian Lung
Hashim, Jamal Hisham
Norback, Dan
author_sort Lim, Fang Lee
title Fractional exhaled nitric oxide (FeNO) among office workers in an academic institution, Malaysia – associations with asthma, allergies and office environment
title_short Fractional exhaled nitric oxide (FeNO) among office workers in an academic institution, Malaysia – associations with asthma, allergies and office environment
title_full Fractional exhaled nitric oxide (FeNO) among office workers in an academic institution, Malaysia – associations with asthma, allergies and office environment
title_fullStr Fractional exhaled nitric oxide (FeNO) among office workers in an academic institution, Malaysia – associations with asthma, allergies and office environment
title_full_unstemmed Fractional exhaled nitric oxide (FeNO) among office workers in an academic institution, Malaysia – associations with asthma, allergies and office environment
title_sort fractional exhaled nitric oxide (feno) among office workers in an academic institution, malaysia – associations with asthma, allergies and office environment
publisher Taylor & Francis
publishDate 2016
url http://psasir.upm.edu.my/id/eprint/47514/1/Fractional%20exhaled%20nitric%20oxide%20%28FeNO%29%20among%20office%20workers%20in%20an%20academic%20institution%2C%20Malaysia%20%E2%80%93%20associations%20with%20asthma%2C%20allergies%20and%20office%20environment.pdf
http://psasir.upm.edu.my/id/eprint/47514/
http://www.tandfonline.com/doi/abs/10.3109/02770903.2015.1077861?journalCode=ijas20
_version_ 1643833900983648256
score 13.211869

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