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Xanthorrhizol: a review of its pharmacological activities and anticancer properties

Xanthorrhizol (XNT) is a bisabolane-type sesquiterpenoid compound extracted from Curcuma xanthorrhiza Roxb. It has been well established to possess a variety of biological activities such as anticancer, antimicrobial, anti-inflammatory, antioxidant, antihyperglycemic, antihypertensive, antiplatelet,...

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Main Authors: Oon, Seok Fang, Nallappan, Meenakshii, Tee, Thiam Tsui, Shohaimi, Shamarina, Kassim, Nur Kartinee, Sa'ariwijaya, Mohd Shazrul Fazry, Cheah, Yew Hoong
Format: Article
Language:English
Published: BioMed Central 2015
Online Access:http://psasir.upm.edu.my/id/eprint/46908/1/Xanthorrhizol%3B%20a%20review%20of%20its%20pharmacological%20activities%20and%20anticancer%20properties.pdf
http://psasir.upm.edu.my/id/eprint/46908/
https://cancerci.biomedcentral.com/articles/10.1186/s12935-015-0255-4
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spelling my.upm.eprints.469082022-05-25T03:35:13Z http://psasir.upm.edu.my/id/eprint/46908/ Xanthorrhizol: a review of its pharmacological activities and anticancer properties Oon, Seok Fang Nallappan, Meenakshii Tee, Thiam Tsui Shohaimi, Shamarina Kassim, Nur Kartinee Sa'ariwijaya, Mohd Shazrul Fazry Cheah, Yew Hoong Xanthorrhizol (XNT) is a bisabolane-type sesquiterpenoid compound extracted from Curcuma xanthorrhiza Roxb. It has been well established to possess a variety of biological activities such as anticancer, antimicrobial, anti-inflammatory, antioxidant, antihyperglycemic, antihypertensive, antiplatelet, nephroprotective, hepatoprotective, estrogenic and anti-estrogenic effects. Since many synthetic drugs possess toxic side effects and are unable to support the increasing prevalence of disease, there is significant interest in developing natural product as new therapeutics. XNT is a very potent natural bioactive compound that could fulfil the current need for new drug discovery. Despite its importance, a comprehensive review of XNT’s pharmacological activities has not been published in the scientific literature to date. Here, the present review aims to summarize the available information in this area, focus on its anticancer properties and indicate the current status of the research. This helps to facilitate the understanding of XNT’s pharmacological role in drug discovery, thus suggesting areas where further research is required. BioMed Central 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/46908/1/Xanthorrhizol%3B%20a%20review%20of%20its%20pharmacological%20activities%20and%20anticancer%20properties.pdf Oon, Seok Fang and Nallappan, Meenakshii and Tee, Thiam Tsui and Shohaimi, Shamarina and Kassim, Nur Kartinee and Sa'ariwijaya, Mohd Shazrul Fazry and Cheah, Yew Hoong (2015) Xanthorrhizol: a review of its pharmacological activities and anticancer properties. Cancer Cell International, 15. art. no. 100. pp. 1-15. ISSN 1475-2867 https://cancerci.biomedcentral.com/articles/10.1186/s12935-015-0255-4 10.1186/s12935-015-0255-4
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Xanthorrhizol (XNT) is a bisabolane-type sesquiterpenoid compound extracted from Curcuma xanthorrhiza Roxb. It has been well established to possess a variety of biological activities such as anticancer, antimicrobial, anti-inflammatory, antioxidant, antihyperglycemic, antihypertensive, antiplatelet, nephroprotective, hepatoprotective, estrogenic and anti-estrogenic effects. Since many synthetic drugs possess toxic side effects and are unable to support the increasing prevalence of disease, there is significant interest in developing natural product as new therapeutics. XNT is a very potent natural bioactive compound that could fulfil the current need for new drug discovery. Despite its importance, a comprehensive review of XNT’s pharmacological activities has not been published in the scientific literature to date. Here, the present review aims to summarize the available information in this area, focus on its anticancer properties and indicate the current status of the research. This helps to facilitate the understanding of XNT’s pharmacological role in drug discovery, thus suggesting areas where further research is required.
format Article
author Oon, Seok Fang
Nallappan, Meenakshii
Tee, Thiam Tsui
Shohaimi, Shamarina
Kassim, Nur Kartinee
Sa'ariwijaya, Mohd Shazrul Fazry
Cheah, Yew Hoong
spellingShingle Oon, Seok Fang
Nallappan, Meenakshii
Tee, Thiam Tsui
Shohaimi, Shamarina
Kassim, Nur Kartinee
Sa'ariwijaya, Mohd Shazrul Fazry
Cheah, Yew Hoong
Xanthorrhizol: a review of its pharmacological activities and anticancer properties
author_facet Oon, Seok Fang
Nallappan, Meenakshii
Tee, Thiam Tsui
Shohaimi, Shamarina
Kassim, Nur Kartinee
Sa'ariwijaya, Mohd Shazrul Fazry
Cheah, Yew Hoong
author_sort Oon, Seok Fang
title Xanthorrhizol: a review of its pharmacological activities and anticancer properties
title_short Xanthorrhizol: a review of its pharmacological activities and anticancer properties
title_full Xanthorrhizol: a review of its pharmacological activities and anticancer properties
title_fullStr Xanthorrhizol: a review of its pharmacological activities and anticancer properties
title_full_unstemmed Xanthorrhizol: a review of its pharmacological activities and anticancer properties
title_sort xanthorrhizol: a review of its pharmacological activities and anticancer properties
publisher BioMed Central
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/46908/1/Xanthorrhizol%3B%20a%20review%20of%20its%20pharmacological%20activities%20and%20anticancer%20properties.pdf
http://psasir.upm.edu.my/id/eprint/46908/
https://cancerci.biomedcentral.com/articles/10.1186/s12935-015-0255-4
_version_ 1734301571858038784
score 13.211869

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