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Sensitive and specific protein sensing using single-mode tapered fiber immobilized with biorecognition molecules

We examine and demonstrate a biosensor using single-mode tapered fiber that has been immobilized with biorecognition molecules to sense targeted proteins. Interaction of evanescent waves with the external medium surrounding the tapered region produces an interferometric-patterned spectrum, which shi...

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Main Authors: Mustapha Kamil, Y., Abu Bakar, Muhammad Hafiz, Mustapa, M. A., Yaacob, Mohd. Hanif, Amir Hamzah, Amir Syahir, Mahdi, Mohd Adzir
Format: Article
Language:English
Published: Institute of Electrical and Electronics Engineers 2015
Online Access:http://psasir.upm.edu.my/id/eprint/46263/1/Sensitive%20and%20specific%20protein%20sensing%20using%20single-mode%20tapered%20fiber%20immobilized%20with%20biorecognition%20molecules.pdf
http://psasir.upm.edu.my/id/eprint/46263/
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spelling my.upm.eprints.462632018-05-02T05:09:08Z http://psasir.upm.edu.my/id/eprint/46263/ Sensitive and specific protein sensing using single-mode tapered fiber immobilized with biorecognition molecules Mustapha Kamil, Y. Abu Bakar, Muhammad Hafiz Mustapa, M. A. Yaacob, Mohd. Hanif Amir Hamzah, Amir Syahir Mahdi, Mohd Adzir We examine and demonstrate a biosensor using single-mode tapered fiber that has been immobilized with biorecognition molecules to sense targeted proteins. Interaction of evanescent waves with the external medium surrounding the tapered region produces an interferometric-patterned spectrum, which shifts correspondingly to any changes of refractive index (RI) in the external medium. The proposed setup managed to obtain an RI sensitivity and concentration sensitivity of 2526.8 nm/RIU and 20.368 nm/μM, respectively, which, to our knowledge, is highly sensitive when compared with previous studies. The dynamic performance, good specificity, and high sensitivity of the proposed method highlight an immensely beneficial choice for immunological diagnostics. Institute of Electrical and Electronics Engineers 2015-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/46263/1/Sensitive%20and%20specific%20protein%20sensing%20using%20single-mode%20tapered%20fiber%20immobilized%20with%20biorecognition%20molecules.pdf Mustapha Kamil, Y. and Abu Bakar, Muhammad Hafiz and Mustapa, M. A. and Yaacob, Mohd. Hanif and Amir Hamzah, Amir Syahir and Mahdi, Mohd Adzir (2015) Sensitive and specific protein sensing using single-mode tapered fiber immobilized with biorecognition molecules. IEEE Photonics Journal, 7 (6). art. no. 3700109. pp. 1-9. ISSN 1943-0655 10.1109/JPHOT.2015.2490486
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description We examine and demonstrate a biosensor using single-mode tapered fiber that has been immobilized with biorecognition molecules to sense targeted proteins. Interaction of evanescent waves with the external medium surrounding the tapered region produces an interferometric-patterned spectrum, which shifts correspondingly to any changes of refractive index (RI) in the external medium. The proposed setup managed to obtain an RI sensitivity and concentration sensitivity of 2526.8 nm/RIU and 20.368 nm/μM, respectively, which, to our knowledge, is highly sensitive when compared with previous studies. The dynamic performance, good specificity, and high sensitivity of the proposed method highlight an immensely beneficial choice for immunological diagnostics.
format Article
author Mustapha Kamil, Y.
Abu Bakar, Muhammad Hafiz
Mustapa, M. A.
Yaacob, Mohd. Hanif
Amir Hamzah, Amir Syahir
Mahdi, Mohd Adzir
spellingShingle Mustapha Kamil, Y.
Abu Bakar, Muhammad Hafiz
Mustapa, M. A.
Yaacob, Mohd. Hanif
Amir Hamzah, Amir Syahir
Mahdi, Mohd Adzir
Sensitive and specific protein sensing using single-mode tapered fiber immobilized with biorecognition molecules
author_facet Mustapha Kamil, Y.
Abu Bakar, Muhammad Hafiz
Mustapa, M. A.
Yaacob, Mohd. Hanif
Amir Hamzah, Amir Syahir
Mahdi, Mohd Adzir
author_sort Mustapha Kamil, Y.
title Sensitive and specific protein sensing using single-mode tapered fiber immobilized with biorecognition molecules
title_short Sensitive and specific protein sensing using single-mode tapered fiber immobilized with biorecognition molecules
title_full Sensitive and specific protein sensing using single-mode tapered fiber immobilized with biorecognition molecules
title_fullStr Sensitive and specific protein sensing using single-mode tapered fiber immobilized with biorecognition molecules
title_full_unstemmed Sensitive and specific protein sensing using single-mode tapered fiber immobilized with biorecognition molecules
title_sort sensitive and specific protein sensing using single-mode tapered fiber immobilized with biorecognition molecules
publisher Institute of Electrical and Electronics Engineers
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/46263/1/Sensitive%20and%20specific%20protein%20sensing%20using%20single-mode%20tapered%20fiber%20immobilized%20with%20biorecognition%20molecules.pdf
http://psasir.upm.edu.my/id/eprint/46263/
_version_ 1643833749734948864
score 13.211869

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