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Probiotic or antibiotic: future challenges in medicine

Genetic and environmental factors can affect the intestinal microbiome and microbial metabolome. Among these environmental factors, the consumption of antibiotics can significantly change the intestinal microbiome of individuals and consequently affect the corresponding metagenome. The term 'pr...

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Main Authors: Nami, Yousef, Haghshenas, Babak, Abdullah, Norhafizah, Barzegari, Abolfazl, Awang Biak, Dayang Radiah, Rosli, Rozita, Khosroushahi, Ahmad Yari
Format: Article
Language:English
Published: Society for General Microbiology 2015
Online Access:http://psasir.upm.edu.my/id/eprint/46008/1/Probiotic%20or%20antibiotic%20future%20challenges%20in%20medicine.pdf
http://psasir.upm.edu.my/id/eprint/46008/
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spelling my.upm.eprints.460082018-05-14T08:46:50Z http://psasir.upm.edu.my/id/eprint/46008/ Probiotic or antibiotic: future challenges in medicine Nami, Yousef Haghshenas, Babak Abdullah, Norhafizah Barzegari, Abolfazl Awang Biak, Dayang Radiah Rosli, Rozita Khosroushahi, Ahmad Yari Genetic and environmental factors can affect the intestinal microbiome and microbial metabolome. Among these environmental factors, the consumption of antibiotics can significantly change the intestinal microbiome of individuals and consequently affect the corresponding metagenome. The term 'probiotics' is related to preventive medicine rather than therapeutic procedures and is, thus, considered the opposite of antibiotics. This review discusses the challenges between these opposing treatments in terms of the following points: (i) antibiotic resistance, the relationship between antibiotic consumption and microbiome diversity reduction, antibiotic effect on the metagenome, and disease associated with antibiotics; and (ii) probiotics as living drugs, probiotic effect on epigenetic alterations, and gut microbiome relevance to hygiene indulgence. The intestinal microbiome is more specific for individuals and may be affected by environmental alterations and the occurrence of diseases. Society for General Microbiology 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/46008/1/Probiotic%20or%20antibiotic%20future%20challenges%20in%20medicine.pdf Nami, Yousef and Haghshenas, Babak and Abdullah, Norhafizah and Barzegari, Abolfazl and Awang Biak, Dayang Radiah and Rosli, Rozita and Khosroushahi, Ahmad Yari (2015) Probiotic or antibiotic: future challenges in medicine. Journal of Medical Microbiology, 64 (2). pp. 137-146. ISSN 0022-2615; ESSN: 1473-5644 10.1099/jmm.0.078923-0
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Genetic and environmental factors can affect the intestinal microbiome and microbial metabolome. Among these environmental factors, the consumption of antibiotics can significantly change the intestinal microbiome of individuals and consequently affect the corresponding metagenome. The term 'probiotics' is related to preventive medicine rather than therapeutic procedures and is, thus, considered the opposite of antibiotics. This review discusses the challenges between these opposing treatments in terms of the following points: (i) antibiotic resistance, the relationship between antibiotic consumption and microbiome diversity reduction, antibiotic effect on the metagenome, and disease associated with antibiotics; and (ii) probiotics as living drugs, probiotic effect on epigenetic alterations, and gut microbiome relevance to hygiene indulgence. The intestinal microbiome is more specific for individuals and may be affected by environmental alterations and the occurrence of diseases.
format Article
author Nami, Yousef
Haghshenas, Babak
Abdullah, Norhafizah
Barzegari, Abolfazl
Awang Biak, Dayang Radiah
Rosli, Rozita
Khosroushahi, Ahmad Yari
spellingShingle Nami, Yousef
Haghshenas, Babak
Abdullah, Norhafizah
Barzegari, Abolfazl
Awang Biak, Dayang Radiah
Rosli, Rozita
Khosroushahi, Ahmad Yari
Probiotic or antibiotic: future challenges in medicine
author_facet Nami, Yousef
Haghshenas, Babak
Abdullah, Norhafizah
Barzegari, Abolfazl
Awang Biak, Dayang Radiah
Rosli, Rozita
Khosroushahi, Ahmad Yari
author_sort Nami, Yousef
title Probiotic or antibiotic: future challenges in medicine
title_short Probiotic or antibiotic: future challenges in medicine
title_full Probiotic or antibiotic: future challenges in medicine
title_fullStr Probiotic or antibiotic: future challenges in medicine
title_full_unstemmed Probiotic or antibiotic: future challenges in medicine
title_sort probiotic or antibiotic: future challenges in medicine
publisher Society for General Microbiology
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/46008/1/Probiotic%20or%20antibiotic%20future%20challenges%20in%20medicine.pdf
http://psasir.upm.edu.my/id/eprint/46008/
_version_ 1643833728567345152
score 13.211869

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