Staff View: In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract

In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract

The anti-Trypanosoma evansi activity of Garcinia hombroniana (seashore mangosteen) leaves aqueous extract was tested on experimentally infected Sprague–Dawley rats. Treatment of infected rats with G. hombroniana extract resulted in a significantly extended post-infection longevity (p < 0.05), com...

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Main Authors:	Dyary, Hiewa O., Abd. Kadir, Arifah, Sharma, Reuben Sunil Kumar, Abdullah, Rasedee, Md. Sukari, Mohd Aspollah, Zakaria, Zainul Amiruddin, Ahmad, Zuraini, Somchit, Muhammad Nazrul
Format:	Article
Language:	English
Published:	Elsevier 2015
Online Access:	http://psasir.upm.edu.my/id/eprint/45114/1/GARCINIA.pdf http://psasir.upm.edu.my/id/eprint/45114/ https://www.sciencedirect.com/science/article/pii/S0034528815000612?via%3Dihub
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id	my.upm.eprints.45114
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spelling	my.upm.eprints.451142021-04-16T02:56:38Z http://psasir.upm.edu.my/id/eprint/45114/ In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract Dyary, Hiewa O. Abd. Kadir, Arifah Sharma, Reuben Sunil Kumar Abdullah, Rasedee Md. Sukari, Mohd Aspollah Zakaria, Zainul Amiruddin Ahmad, Zuraini Somchit, Muhammad Nazrul The anti-Trypanosoma evansi activity of Garcinia hombroniana (seashore mangosteen) leaves aqueous extract was tested on experimentally infected Sprague–Dawley rats. Treatment of infected rats with G. hombroniana extract resulted in a significantly extended post-infection longevity (p < 0.05), compared to the untreated control group. The possible mode of antitrypanosomal effect of the plant extract was also investigated on cultured T. evansi in HMI-9 medium with the addition of 25 µg/ml G. hombroniana aqueous extract. It was observed that the addition of G. hombroniana extract resulted in the inhibition of trypanosomal kinetoplast division, with no significant inhibitory effect on nuclear division. It is concluded from the current study that the aqueous extract of G. hombroniana has a potential antitrypanosomal activity through the inhibition of kinetoplast division, as one of the possible mechanisms of its antitrypanosomal effect. This plant could serve as a possible source of new antitrypanosomal compounds. Elsevier 2015-06 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/45114/1/GARCINIA.pdf Dyary, Hiewa O. and Abd. Kadir, Arifah and Sharma, Reuben Sunil Kumar and Abdullah, Rasedee and Md. Sukari, Mohd Aspollah and Zakaria, Zainul Amiruddin and Ahmad, Zuraini and Somchit, Muhammad Nazrul (2015) In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract. Research in Veterinary Science, 100. pp. 226-231. ISSN 0034-5288; ESSN: 1532-2661 https://www.sciencedirect.com/science/article/pii/S0034528815000612?via%3Dihub 10.1016/j.rvsc.2015.03.007
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
language	English
description	The anti-Trypanosoma evansi activity of Garcinia hombroniana (seashore mangosteen) leaves aqueous extract was tested on experimentally infected Sprague–Dawley rats. Treatment of infected rats with G. hombroniana extract resulted in a significantly extended post-infection longevity (p < 0.05), compared to the untreated control group. The possible mode of antitrypanosomal effect of the plant extract was also investigated on cultured T. evansi in HMI-9 medium with the addition of 25 µg/ml G. hombroniana aqueous extract. It was observed that the addition of G. hombroniana extract resulted in the inhibition of trypanosomal kinetoplast division, with no significant inhibitory effect on nuclear division. It is concluded from the current study that the aqueous extract of G. hombroniana has a potential antitrypanosomal activity through the inhibition of kinetoplast division, as one of the possible mechanisms of its antitrypanosomal effect. This plant could serve as a possible source of new antitrypanosomal compounds.
format	Article
author	Dyary, Hiewa O. Abd. Kadir, Arifah Sharma, Reuben Sunil Kumar Abdullah, Rasedee Md. Sukari, Mohd Aspollah Zakaria, Zainul Amiruddin Ahmad, Zuraini Somchit, Muhammad Nazrul
spellingShingle	Dyary, Hiewa O. Abd. Kadir, Arifah Sharma, Reuben Sunil Kumar Abdullah, Rasedee Md. Sukari, Mohd Aspollah Zakaria, Zainul Amiruddin Ahmad, Zuraini Somchit, Muhammad Nazrul In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract
author_facet	Dyary, Hiewa O. Abd. Kadir, Arifah Sharma, Reuben Sunil Kumar Abdullah, Rasedee Md. Sukari, Mohd Aspollah Zakaria, Zainul Amiruddin Ahmad, Zuraini Somchit, Muhammad Nazrul
author_sort	Dyary, Hiewa O.
title	In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract
title_short	In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract
title_full	In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract
title_fullStr	In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract
title_full_unstemmed	In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract
title_sort	in vivo antitrypanosomal activity of garcinia hombroniana aqueous extract
publisher	Elsevier
publishDate	2015
url	http://psasir.upm.edu.my/id/eprint/45114/1/GARCINIA.pdf http://psasir.upm.edu.my/id/eprint/45114/ https://www.sciencedirect.com/science/article/pii/S0034528815000612?via%3Dihub
_version_	1698698918180683776
score	13.211869

In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract

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