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The Efficacy of Selected Herbs in Delaying the Ageing Process as Indicated by the Reduction in Plasma Malondialdehyde Levels

Effects of selected herbs in delaying ageing in rats were studied by measuring the activity of plasma malondialdehyde (MDA) as an index of lipid peroxidation status. Likewise, the activities of anti-oxidative enzymes such as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (G...

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Main Author: Ismail, Imilia
Format: Thesis
Language:English
Published: 2004
Online Access:http://psasir.upm.edu.my/id/eprint/45/1/1000548959_fpv_2004_20.pdf
http://psasir.upm.edu.my/id/eprint/45/
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spelling my.upm.eprints.452015-08-06T02:06:22Z http://psasir.upm.edu.my/id/eprint/45/ The Efficacy of Selected Herbs in Delaying the Ageing Process as Indicated by the Reduction in Plasma Malondialdehyde Levels Ismail, Imilia Effects of selected herbs in delaying ageing in rats were studied by measuring the activity of plasma malondialdehyde (MDA) as an index of lipid peroxidation status. Likewise, the activities of anti-oxidative enzymes such as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were also assessed as indices of anti-oxidant. Descriptive histological changes in the brain, liver, kidney and heart were also performed, while, quantitative histology was determined by counting the necrotic cells and lipofuscin pigments in the liver, the glomeruli in the kidney, and the neuron cells in the brain. Fifty male Sprague-Dawley rats each of the 4-week and 10-month old respectively were used. All rats were divided equally into 10 groups. While the control group was given the basal diet, other groups were fed the basal diet containing 5% of Sireh (Piper betle; S), Bunga Kantan (Pheaomeria speciosa; BK), Dukong Anak (Phyllanthus niruri; DA) or Pucuk Gajus (Anacardium occidentale L.; PG). Blood 4 samples for biochemical analysis were taken every three weeks by intracardiac puncture. The results showed that at almost all instances, the concentration of MDA in the controls were significantly (p<0.05) higher than any other groups. The concentration of MDA was been markedly reduced by herbal supplementation. Likewise, supplementation had also exerted its protective effect against ageing by increasing the activity of anti-oxidant enzymes. Such effective scavenging mechanism in the herbal supplemented group had led to less ageing lesion development in these rats. In conclusion, the selected herbs especially those of DA and PG were able to alleviate ageing-induced injuries in rats via boosting the scavenging system or generating anti-oxidant-like compounds. 2004-12 Thesis NonPeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/45/1/1000548959_fpv_2004_20.pdf Ismail, Imilia (2004) The Efficacy of Selected Herbs in Delaying the Ageing Process as Indicated by the Reduction in Plasma Malondialdehyde Levels. Masters thesis, Universiti Putra Malaysia.
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Effects of selected herbs in delaying ageing in rats were studied by measuring the activity of plasma malondialdehyde (MDA) as an index of lipid peroxidation status. Likewise, the activities of anti-oxidative enzymes such as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were also assessed as indices of anti-oxidant. Descriptive histological changes in the brain, liver, kidney and heart were also performed, while, quantitative histology was determined by counting the necrotic cells and lipofuscin pigments in the liver, the glomeruli in the kidney, and the neuron cells in the brain. Fifty male Sprague-Dawley rats each of the 4-week and 10-month old respectively were used. All rats were divided equally into 10 groups. While the control group was given the basal diet, other groups were fed the basal diet containing 5% of Sireh (Piper betle; S), Bunga Kantan (Pheaomeria speciosa; BK), Dukong Anak (Phyllanthus niruri; DA) or Pucuk Gajus (Anacardium occidentale L.; PG). Blood 4 samples for biochemical analysis were taken every three weeks by intracardiac puncture. The results showed that at almost all instances, the concentration of MDA in the controls were significantly (p<0.05) higher than any other groups. The concentration of MDA was been markedly reduced by herbal supplementation. Likewise, supplementation had also exerted its protective effect against ageing by increasing the activity of anti-oxidant enzymes. Such effective scavenging mechanism in the herbal supplemented group had led to less ageing lesion development in these rats. In conclusion, the selected herbs especially those of DA and PG were able to alleviate ageing-induced injuries in rats via boosting the scavenging system or generating anti-oxidant-like compounds.
format Thesis
author Ismail, Imilia
spellingShingle Ismail, Imilia
The Efficacy of Selected Herbs in Delaying the Ageing Process as Indicated by the Reduction in Plasma Malondialdehyde Levels
author_facet Ismail, Imilia
author_sort Ismail, Imilia
title The Efficacy of Selected Herbs in Delaying the Ageing Process as Indicated by the Reduction in Plasma Malondialdehyde Levels
title_short The Efficacy of Selected Herbs in Delaying the Ageing Process as Indicated by the Reduction in Plasma Malondialdehyde Levels
title_full The Efficacy of Selected Herbs in Delaying the Ageing Process as Indicated by the Reduction in Plasma Malondialdehyde Levels
title_fullStr The Efficacy of Selected Herbs in Delaying the Ageing Process as Indicated by the Reduction in Plasma Malondialdehyde Levels
title_full_unstemmed The Efficacy of Selected Herbs in Delaying the Ageing Process as Indicated by the Reduction in Plasma Malondialdehyde Levels
title_sort efficacy of selected herbs in delaying the ageing process as indicated by the reduction in plasma malondialdehyde levels
publishDate 2004
url http://psasir.upm.edu.my/id/eprint/45/1/1000548959_fpv_2004_20.pdf
http://psasir.upm.edu.my/id/eprint/45/
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score 13.211869

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