Formulation and evaluation of galantamine gel as drug reservoir in transdermal patch delivery system
Galantamine hydrobromide is formulated in tablets and capsules prescribed through oral delivery for the treatment of Alzheimer’s disease. However, oral delivery of drugs can cause severe side effects such as nausea, vomiting, and gastrointestinal disturbance. Transdermal delivery of galantamine hy...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/44846/1/Formulation%20and%20evaluation%20of%20galantamine%20gel%20as%20drug%20reservoir%20in%20transdermal%20patch%20delivery%20system%20.pdf http://psasir.upm.edu.my/id/eprint/44846/ https://www.hindawi.com/journals/tswj/2015/495271/ |
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| Summary: | Galantamine hydrobromide is formulated in tablets and capsules prescribed through oral delivery for the treatment of
Alzheimer’s disease. However, oral delivery of drugs can cause severe side effects such as nausea, vomiting, and gastrointestinal
disturbance. Transdermal delivery of galantamine hydrobromide could avoid these unwanted side effects. In this work, galantamine
hydrobromide was formulated in gel drug reservoir which was then fabricated in the transdermal patch. The in vitro drug release
studies revealed that the drug release from the donor chamber to receptor chamber of Franz diffusion cell was affected by the
amount of polymer, amount of neutralizer, amount of drug, types of permeation enhancer, and amount of permeation enhancer.
Visual observations of the gels showed that all formulated gels are translucent, homogeneous, smooth, and stable. These gels have
pH in the suitable range for skin. The gel also showed high drug content uniformity. Hence, this formulation can be further used
in the preparation of transdermal patch drug delivery system. |
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