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Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions

An increasing number of studies suggest an important role of host immunity as a barrier to tumor formation and progression. Complex mechanisms and multiple pathways are involved in evading innate and adaptive immune responses, with a broad spectrum of chemicals displaying the potential to adversely...

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Main Authors: Kravchenko, Julia, Corsini, Emanuela, Williams, Marc A., Decker, William, Manjili, Masoud H., Otsuki, Takemi, Singh, Neetu, Al-Mulla, Faha, Al-Temaimi, Rabeah, Amedei, Amedeo, Colacci, Anna Maria, Vaccari, Monica, Mondello, Chiara, Scovassi, A. Ivana, Raju, Jayadev, A. Hamid, Roslida, Memeo, Lorenzo, Forte, Stefano, Roy, Rabindra, Woodrick, Jordan, Salem, Hosni K.
Format: Article
Language:English
Published: Oxford University Press 2015
Online Access:http://psasir.upm.edu.my/id/eprint/44049/1/Chemical%20compounds%20from%20anthropogenic%20environment%20and%20immune%20evasion%20mechanisms%20potential%20interactions.pdf
http://psasir.upm.edu.my/id/eprint/44049/
https://academic.oup.com/carcin/article/36/Suppl_1/S111/313145
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spelling my.upm.eprints.440492022-03-14T04:16:23Z http://psasir.upm.edu.my/id/eprint/44049/ Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions Kravchenko, Julia Corsini, Emanuela Williams, Marc A. Decker, William Manjili, Masoud H. Otsuki, Takemi Singh, Neetu Al-Mulla, Faha Al-Temaimi, Rabeah Amedei, Amedeo Colacci, Anna Maria Vaccari, Monica Mondello, Chiara Scovassi, A. Ivana Raju, Jayadev A. Hamid, Roslida Memeo, Lorenzo Forte, Stefano Roy, Rabindra Woodrick, Jordan Salem, Hosni K. An increasing number of studies suggest an important role of host immunity as a barrier to tumor formation and progression. Complex mechanisms and multiple pathways are involved in evading innate and adaptive immune responses, with a broad spectrum of chemicals displaying the potential to adversely influence immunosurveillance. The evaluation of the cumulative effects of low-dose exposures from the occupational and natural environment, especially if multiple chemicals target the same gene(s) or pathway(s), is a challenge. We reviewed common environmental chemicals and discussed their potential effects on immunosurveillance. Our overarching objective was to review related signaling pathways influencing immune surveillance such as the pathways involving PI3K/Akt, chemokines, TGF-β, FAK, IGF-1, HIF-1α, IL-6, IL-1α, CTLA-4 and PD-1/PDL-1 could individually or collectively impact immunosurveillance. A number of chemicals that are common in the anthropogenic environment such as fungicides (maneb, fluoxastrobin and pyroclostrobin), herbicides (atrazine), insecticides (pyridaben and azamethiphos), the components of personal care products (triclosan and bisphenol A) and diethylhexylphthalate with pathways critical to tumor immunosurveillance. At this time, these chemicals are not recognized as human carcinogens; however, it is known that they these chemicalscan simultaneously persist in the environment and appear to have some potential interfere with the host immune response, therefore potentially contributing to promotion interacting with of immune evasion mechanisms, and promoting subsequent tumor growth and progression. Oxford University Press 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/44049/1/Chemical%20compounds%20from%20anthropogenic%20environment%20and%20immune%20evasion%20mechanisms%20potential%20interactions.pdf Kravchenko, Julia and Corsini, Emanuela and Williams, Marc A. and Decker, William and Manjili, Masoud H. and Otsuki, Takemi and Singh, Neetu and Al-Mulla, Faha and Al-Temaimi, Rabeah and Amedei, Amedeo and Colacci, Anna Maria and Vaccari, Monica and Mondello, Chiara and Scovassi, A. Ivana and Raju, Jayadev and A. Hamid, Roslida and Memeo, Lorenzo and Forte, Stefano and Roy, Rabindra and Woodrick, Jordan and Salem, Hosni K. (2015) Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions. Carcinogenesis, 36 (suppl. 1). pp. 111-127. ISSN 0143-3334; ESSN: 1460-2180 https://academic.oup.com/carcin/article/36/Suppl_1/S111/313145 10.1093/carcin/bgv033
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description An increasing number of studies suggest an important role of host immunity as a barrier to tumor formation and progression. Complex mechanisms and multiple pathways are involved in evading innate and adaptive immune responses, with a broad spectrum of chemicals displaying the potential to adversely influence immunosurveillance. The evaluation of the cumulative effects of low-dose exposures from the occupational and natural environment, especially if multiple chemicals target the same gene(s) or pathway(s), is a challenge. We reviewed common environmental chemicals and discussed their potential effects on immunosurveillance. Our overarching objective was to review related signaling pathways influencing immune surveillance such as the pathways involving PI3K/Akt, chemokines, TGF-β, FAK, IGF-1, HIF-1α, IL-6, IL-1α, CTLA-4 and PD-1/PDL-1 could individually or collectively impact immunosurveillance. A number of chemicals that are common in the anthropogenic environment such as fungicides (maneb, fluoxastrobin and pyroclostrobin), herbicides (atrazine), insecticides (pyridaben and azamethiphos), the components of personal care products (triclosan and bisphenol A) and diethylhexylphthalate with pathways critical to tumor immunosurveillance. At this time, these chemicals are not recognized as human carcinogens; however, it is known that they these chemicalscan simultaneously persist in the environment and appear to have some potential interfere with the host immune response, therefore potentially contributing to promotion interacting with of immune evasion mechanisms, and promoting subsequent tumor growth and progression.
format Article
author Kravchenko, Julia
Corsini, Emanuela
Williams, Marc A.
Decker, William
Manjili, Masoud H.
Otsuki, Takemi
Singh, Neetu
Al-Mulla, Faha
Al-Temaimi, Rabeah
Amedei, Amedeo
Colacci, Anna Maria
Vaccari, Monica
Mondello, Chiara
Scovassi, A. Ivana
Raju, Jayadev
A. Hamid, Roslida
Memeo, Lorenzo
Forte, Stefano
Roy, Rabindra
Woodrick, Jordan
Salem, Hosni K.
spellingShingle Kravchenko, Julia
Corsini, Emanuela
Williams, Marc A.
Decker, William
Manjili, Masoud H.
Otsuki, Takemi
Singh, Neetu
Al-Mulla, Faha
Al-Temaimi, Rabeah
Amedei, Amedeo
Colacci, Anna Maria
Vaccari, Monica
Mondello, Chiara
Scovassi, A. Ivana
Raju, Jayadev
A. Hamid, Roslida
Memeo, Lorenzo
Forte, Stefano
Roy, Rabindra
Woodrick, Jordan
Salem, Hosni K.
Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions
author_facet Kravchenko, Julia
Corsini, Emanuela
Williams, Marc A.
Decker, William
Manjili, Masoud H.
Otsuki, Takemi
Singh, Neetu
Al-Mulla, Faha
Al-Temaimi, Rabeah
Amedei, Amedeo
Colacci, Anna Maria
Vaccari, Monica
Mondello, Chiara
Scovassi, A. Ivana
Raju, Jayadev
A. Hamid, Roslida
Memeo, Lorenzo
Forte, Stefano
Roy, Rabindra
Woodrick, Jordan
Salem, Hosni K.
author_sort Kravchenko, Julia
title Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions
title_short Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions
title_full Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions
title_fullStr Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions
title_full_unstemmed Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions
title_sort chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions
publisher Oxford University Press
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/44049/1/Chemical%20compounds%20from%20anthropogenic%20environment%20and%20immune%20evasion%20mechanisms%20potential%20interactions.pdf
http://psasir.upm.edu.my/id/eprint/44049/
https://academic.oup.com/carcin/article/36/Suppl_1/S111/313145
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score 13.211869

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