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Candida isolates from pregnant women and their antifungal susceptibility in a Malaysian tertiary-care hospital

Objective: Pregnant women are susceptible to vaginal colonization and infection by yeast. The purpose of the study was to determine the prevalence of Candida spp in high vaginal swabs of pregnant women and their antifungal susceptibility. Methods: High vaginal swab samples received from Serdang Hosp...

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Main Authors: Masri, Siti Norbaya, Md Noor, Sabariah, Mat Nor, Lailatul Akmar, Osman, Malina, Rahman, Md Mostafizur
Format: Article
Language:English
Published: Professional Medical Publications 2015
Online Access:http://psasir.upm.edu.my/id/eprint/43990/1/Candida%20isolates%20from%20pregnant%20women%20and%20their%20antifungal%20susceptibility%20in%20a%20Malaysian%20tertiary-care%20hospital.pdf
http://psasir.upm.edu.my/id/eprint/43990/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485290/
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spelling my.upm.eprints.439902022-02-10T01:01:15Z http://psasir.upm.edu.my/id/eprint/43990/ Candida isolates from pregnant women and their antifungal susceptibility in a Malaysian tertiary-care hospital Masri, Siti Norbaya Md Noor, Sabariah Mat Nor, Lailatul Akmar Osman, Malina Rahman, Md Mostafizur Objective: Pregnant women are susceptible to vaginal colonization and infection by yeast. The purpose of the study was to determine the prevalence of Candida spp in high vaginal swabs of pregnant women and their antifungal susceptibility. Methods: High vaginal swab samples received from Serdang Hospital, Selangor, Malaysia during 2011 initially had microscopic examination, Gram-staining and fungal culture. These were finally confirmed by growth in chromogenic medium (CHROMagarCandida; Difco BBL, USA) and commercial biochemical identification kit (API 20C AUX; bioMérieux, Lyon, France). Antifungal susceptibility was performed by E-test method. Results: Out of 1163 specimens 200 (17.2%) candida spp were confirmed from high vaginal swabs of pregnant women. Candida albicans (83.5%) is the most common species detected followed by Candida glabrata (16%) and Candida famata (0.05%). All C.albicans and C.famata isolates were susceptible to fluconazole while C.glabrata isolates were dose dependent susceptibility. First and second trimester, and diabetes were considered significant factors in patients for the vaginal candidiasis (p < 0.001). Conclusions: In pregnant women, C. albicans was the frequently isolated yeast from high vaginal swabs. Routine screening and treatment are important of pregnant women regardless of symptoms. Professional Medical Publications 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/43990/1/Candida%20isolates%20from%20pregnant%20women%20and%20their%20antifungal%20susceptibility%20in%20a%20Malaysian%20tertiary-care%20hospital.pdf Masri, Siti Norbaya and Md Noor, Sabariah and Mat Nor, Lailatul Akmar and Osman, Malina and Rahman, Md Mostafizur (2015) Candida isolates from pregnant women and their antifungal susceptibility in a Malaysian tertiary-care hospital. Pakistan Journal of Medical Sciences, 31 (3). pp. 658-661. ISSN 1682-024X; ESSN: 1681-715X https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485290/ 10.12669/pjms.313.7072
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Objective: Pregnant women are susceptible to vaginal colonization and infection by yeast. The purpose of the study was to determine the prevalence of Candida spp in high vaginal swabs of pregnant women and their antifungal susceptibility. Methods: High vaginal swab samples received from Serdang Hospital, Selangor, Malaysia during 2011 initially had microscopic examination, Gram-staining and fungal culture. These were finally confirmed by growth in chromogenic medium (CHROMagarCandida; Difco BBL, USA) and commercial biochemical identification kit (API 20C AUX; bioMérieux, Lyon, France). Antifungal susceptibility was performed by E-test method. Results: Out of 1163 specimens 200 (17.2%) candida spp were confirmed from high vaginal swabs of pregnant women. Candida albicans (83.5%) is the most common species detected followed by Candida glabrata (16%) and Candida famata (0.05%). All C.albicans and C.famata isolates were susceptible to fluconazole while C.glabrata isolates were dose dependent susceptibility. First and second trimester, and diabetes were considered significant factors in patients for the vaginal candidiasis (p < 0.001). Conclusions: In pregnant women, C. albicans was the frequently isolated yeast from high vaginal swabs. Routine screening and treatment are important of pregnant women regardless of symptoms.
format Article
author Masri, Siti Norbaya
Md Noor, Sabariah
Mat Nor, Lailatul Akmar
Osman, Malina
Rahman, Md Mostafizur
spellingShingle Masri, Siti Norbaya
Md Noor, Sabariah
Mat Nor, Lailatul Akmar
Osman, Malina
Rahman, Md Mostafizur
Candida isolates from pregnant women and their antifungal susceptibility in a Malaysian tertiary-care hospital
author_facet Masri, Siti Norbaya
Md Noor, Sabariah
Mat Nor, Lailatul Akmar
Osman, Malina
Rahman, Md Mostafizur
author_sort Masri, Siti Norbaya
title Candida isolates from pregnant women and their antifungal susceptibility in a Malaysian tertiary-care hospital
title_short Candida isolates from pregnant women and their antifungal susceptibility in a Malaysian tertiary-care hospital
title_full Candida isolates from pregnant women and their antifungal susceptibility in a Malaysian tertiary-care hospital
title_fullStr Candida isolates from pregnant women and their antifungal susceptibility in a Malaysian tertiary-care hospital
title_full_unstemmed Candida isolates from pregnant women and their antifungal susceptibility in a Malaysian tertiary-care hospital
title_sort candida isolates from pregnant women and their antifungal susceptibility in a malaysian tertiary-care hospital
publisher Professional Medical Publications
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/43990/1/Candida%20isolates%20from%20pregnant%20women%20and%20their%20antifungal%20susceptibility%20in%20a%20Malaysian%20tertiary-care%20hospital.pdf
http://psasir.upm.edu.my/id/eprint/43990/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485290/
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score 13.211869

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