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Acute and sub-chronic toxicity of a trypsin-modulating oostatic factor (TMOF) on the growth, body composition and histopathology of red hybrid tilapia, Oreochromis sp. as a non-target organism

Trypsin-modulating oostatic factors (TMOF) have been shown to be an effective larvicide to mosquitos as a means of controlling their populations and spread of diseases, however there is limited information on its effects to fish, a non-target organism. Two experiments were performed to assess the ac...

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Main Authors: Romano, Nicholas Paul, Ayob, Noor Mursyida, Sarker, S. M. Nurul Amin Harmuj Ali, Kamarudin, Mohd Salleh
Format: Article
Language:English
Published: Crop Protection Research Centre, Manonmaniam Sundaranar University 2015
Online Access:http://psasir.upm.edu.my/id/eprint/43651/1/Acute%20and%20sub-chronic%20toxicity%20of%20a%20trypsin-modulating%20oostatic%20factor%20.pdf
http://psasir.upm.edu.my/id/eprint/43651/
http://www.jbiopest.com/users/LW8/efiles/vol_8_1_45-51.pdf
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spelling my.upm.eprints.436512017-09-25T13:45:13Z http://psasir.upm.edu.my/id/eprint/43651/ Acute and sub-chronic toxicity of a trypsin-modulating oostatic factor (TMOF) on the growth, body composition and histopathology of red hybrid tilapia, Oreochromis sp. as a non-target organism Romano, Nicholas Paul Ayob, Noor Mursyida Sarker, S. M. Nurul Amin Harmuj Ali Kamarudin, Mohd Salleh Trypsin-modulating oostatic factors (TMOF) have been shown to be an effective larvicide to mosquitos as a means of controlling their populations and spread of diseases, however there is limited information on its effects to fish, a non-target organism. Two experiments were performed to assess the acute and sub-chronic toxicity of a TMOF product to tilapia. For the acute toxicity test, treatments consisted of a control (0), 100, 500, 1000, 1500 and 2000 mg/L TMOF, which were triplicated with 10 fish/replicate according to the static renewal method. For the sub-chronic test, there were four triplicated treatments (50 fish/replicate) consisting of a control, TMOF at 60 mg/L, TMOF treated diets and a combination of these and the test was conducted for 35 days. After 35 days, growth performance, hepatosomatic index (HSI), vicersomatic index (VSI), whole-body proximate composition, and histopathology of the gills, liver and intestine were recorded. No LC50 values were obtained, even when using TMOF at saturated levels, within 96 hours. Meanwhile, after 35 days no significant differences in all of the measured parameters were detected among the treatments. Based on these findings, the TMOF product showed no acute or sub-chronic toxicity to tilapia and is safe to this non-target organism. Crop Protection Research Centre, Manonmaniam Sundaranar University 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/43651/1/Acute%20and%20sub-chronic%20toxicity%20of%20a%20trypsin-modulating%20oostatic%20factor%20.pdf Romano, Nicholas Paul and Ayob, Noor Mursyida and Sarker, S. M. Nurul Amin Harmuj Ali and Kamarudin, Mohd Salleh (2015) Acute and sub-chronic toxicity of a trypsin-modulating oostatic factor (TMOF) on the growth, body composition and histopathology of red hybrid tilapia, Oreochromis sp. as a non-target organism. Journal of Biopesticides, 8 (1). pp. 45-51. ISSN 0974-391X http://www.jbiopest.com/users/LW8/efiles/vol_8_1_45-51.pdf
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Trypsin-modulating oostatic factors (TMOF) have been shown to be an effective larvicide to mosquitos as a means of controlling their populations and spread of diseases, however there is limited information on its effects to fish, a non-target organism. Two experiments were performed to assess the acute and sub-chronic toxicity of a TMOF product to tilapia. For the acute toxicity test, treatments consisted of a control (0), 100, 500, 1000, 1500 and 2000 mg/L TMOF, which were triplicated with 10 fish/replicate according to the static renewal method. For the sub-chronic test, there were four triplicated treatments (50 fish/replicate) consisting of a control, TMOF at 60 mg/L, TMOF treated diets and a combination of these and the test was conducted for 35 days. After 35 days, growth performance, hepatosomatic index (HSI), vicersomatic index (VSI), whole-body proximate composition, and histopathology of the gills, liver and intestine were recorded. No LC50 values were obtained, even when using TMOF at saturated levels, within 96 hours. Meanwhile, after 35 days no significant differences in all of the measured parameters were detected among the treatments. Based on these findings, the TMOF product showed no acute or sub-chronic toxicity to tilapia and is safe to this non-target organism.
format Article
author Romano, Nicholas Paul
Ayob, Noor Mursyida
Sarker, S. M. Nurul Amin Harmuj Ali
Kamarudin, Mohd Salleh
spellingShingle Romano, Nicholas Paul
Ayob, Noor Mursyida
Sarker, S. M. Nurul Amin Harmuj Ali
Kamarudin, Mohd Salleh
Acute and sub-chronic toxicity of a trypsin-modulating oostatic factor (TMOF) on the growth, body composition and histopathology of red hybrid tilapia, Oreochromis sp. as a non-target organism
author_facet Romano, Nicholas Paul
Ayob, Noor Mursyida
Sarker, S. M. Nurul Amin Harmuj Ali
Kamarudin, Mohd Salleh
author_sort Romano, Nicholas Paul
title Acute and sub-chronic toxicity of a trypsin-modulating oostatic factor (TMOF) on the growth, body composition and histopathology of red hybrid tilapia, Oreochromis sp. as a non-target organism
title_short Acute and sub-chronic toxicity of a trypsin-modulating oostatic factor (TMOF) on the growth, body composition and histopathology of red hybrid tilapia, Oreochromis sp. as a non-target organism
title_full Acute and sub-chronic toxicity of a trypsin-modulating oostatic factor (TMOF) on the growth, body composition and histopathology of red hybrid tilapia, Oreochromis sp. as a non-target organism
title_fullStr Acute and sub-chronic toxicity of a trypsin-modulating oostatic factor (TMOF) on the growth, body composition and histopathology of red hybrid tilapia, Oreochromis sp. as a non-target organism
title_full_unstemmed Acute and sub-chronic toxicity of a trypsin-modulating oostatic factor (TMOF) on the growth, body composition and histopathology of red hybrid tilapia, Oreochromis sp. as a non-target organism
title_sort acute and sub-chronic toxicity of a trypsin-modulating oostatic factor (tmof) on the growth, body composition and histopathology of red hybrid tilapia, oreochromis sp. as a non-target organism
publisher Crop Protection Research Centre, Manonmaniam Sundaranar University
publishDate 2015
url http://psasir.upm.edu.my/id/eprint/43651/1/Acute%20and%20sub-chronic%20toxicity%20of%20a%20trypsin-modulating%20oostatic%20factor%20.pdf
http://psasir.upm.edu.my/id/eprint/43651/
http://www.jbiopest.com/users/LW8/efiles/vol_8_1_45-51.pdf
_version_ 1643833628672655360
score 13.211869

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