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Effects on of dexamethasone on vaccination responses against pneumonic pasteurellosis in goats

A study was conducted to compare the effect of dexamethasone treatment prior to, during and post-vaccination on antibody response and protection against experimental challenge with Mannhaemia haemolytica. Sixteen goats of about 7 months old were divided into 4 equal groups. All goats were vaccinated...

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Main Authors: Abdul Razak, Intan Shameha, Saad, Mohd Zamri
Format: Article
Language:English
Published: Veterinary Association Malaysia 2005
Online Access:http://psasir.upm.edu.my/id/eprint/41480/1/0001.pdf
http://psasir.upm.edu.my/id/eprint/41480/
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spelling my.upm.eprints.414802015-12-21T08:33:30Z http://psasir.upm.edu.my/id/eprint/41480/ Effects on of dexamethasone on vaccination responses against pneumonic pasteurellosis in goats Abdul Razak, Intan Shameha Saad, Mohd Zamri A study was conducted to compare the effect of dexamethasone treatment prior to, during and post-vaccination on antibody response and protection against experimental challenge with Mannhaemia haemolytica. Sixteen goats of about 7 months old were divided into 4 equal groups. All goats were vaccinated twice intranasally with 1 ml inoculum containing 106 colony forming unit (cfu) of formalin-killed Mannhaemia haemolytica A2/ml. The two doses were administered at 2-week intervals. Goats in group 1 were treated with dexamethasone prior to vaccination, group 2 was treated during vaccination, group 3 was treated at 1 week-post vaccination while group 4 remained as the vaccinated control. Serum samples were collected weekly for a period of 5 weeks to detect antibody using an ELISA. Two weeks post-vaccination, all goats were challenged intratracheally with 4 ml inoculum containing live Mannhaemia haemolytica at a concentration of 109 cfu/ml before slaughtering at 2 weeks post-challenge. The extent of pneumonic lung lesions was determined. Generally, animals without dexamethasone treatment had significantly (p<0.05) high antibody response compared to other groups while the extent of pneumonic lung lesions was significantly (p<0.05) lowest. Although group 1 showed the second highest antibody response and a lower percentage of lesions, the differences were significant (p<0.05) compared to the control group. Group 2 which showed the second lowest antibody response recorded significantly (p<0.05) extensive lung lesions while group 3, which showed the lowest antibody level had insignificantly (p<0.05) more extensive lung lesions. There were strong correlations between the antibody response and the severity of lesions. The results emphasise that vaccination will not be efficient if carried out when the animal is under stressful conditions. Veterinary Association Malaysia 2005-12 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/41480/1/0001.pdf Abdul Razak, Intan Shameha and Saad, Mohd Zamri (2005) Effects on of dexamethasone on vaccination responses against pneumonic pasteurellosis in goats. Jurnal Veterinar Malaysia, 17 (2). pp. 19-23. ISSN 9128-2506
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description A study was conducted to compare the effect of dexamethasone treatment prior to, during and post-vaccination on antibody response and protection against experimental challenge with Mannhaemia haemolytica. Sixteen goats of about 7 months old were divided into 4 equal groups. All goats were vaccinated twice intranasally with 1 ml inoculum containing 106 colony forming unit (cfu) of formalin-killed Mannhaemia haemolytica A2/ml. The two doses were administered at 2-week intervals. Goats in group 1 were treated with dexamethasone prior to vaccination, group 2 was treated during vaccination, group 3 was treated at 1 week-post vaccination while group 4 remained as the vaccinated control. Serum samples were collected weekly for a period of 5 weeks to detect antibody using an ELISA. Two weeks post-vaccination, all goats were challenged intratracheally with 4 ml inoculum containing live Mannhaemia haemolytica at a concentration of 109 cfu/ml before slaughtering at 2 weeks post-challenge. The extent of pneumonic lung lesions was determined. Generally, animals without dexamethasone treatment had significantly (p<0.05) high antibody response compared to other groups while the extent of pneumonic lung lesions was significantly (p<0.05) lowest. Although group 1 showed the second highest antibody response and a lower percentage of lesions, the differences were significant (p<0.05) compared to the control group. Group 2 which showed the second lowest antibody response recorded significantly (p<0.05) extensive lung lesions while group 3, which showed the lowest antibody level had insignificantly (p<0.05) more extensive lung lesions. There were strong correlations between the antibody response and the severity of lesions. The results emphasise that vaccination will not be efficient if carried out when the animal is under stressful conditions.
format Article
author Abdul Razak, Intan Shameha
Saad, Mohd Zamri
spellingShingle Abdul Razak, Intan Shameha
Saad, Mohd Zamri
Effects on of dexamethasone on vaccination responses against pneumonic pasteurellosis in goats
author_facet Abdul Razak, Intan Shameha
Saad, Mohd Zamri
author_sort Abdul Razak, Intan Shameha
title Effects on of dexamethasone on vaccination responses against pneumonic pasteurellosis in goats
title_short Effects on of dexamethasone on vaccination responses against pneumonic pasteurellosis in goats
title_full Effects on of dexamethasone on vaccination responses against pneumonic pasteurellosis in goats
title_fullStr Effects on of dexamethasone on vaccination responses against pneumonic pasteurellosis in goats
title_full_unstemmed Effects on of dexamethasone on vaccination responses against pneumonic pasteurellosis in goats
title_sort effects on of dexamethasone on vaccination responses against pneumonic pasteurellosis in goats
publisher Veterinary Association Malaysia
publishDate 2005
url http://psasir.upm.edu.my/id/eprint/41480/1/0001.pdf
http://psasir.upm.edu.my/id/eprint/41480/
_version_ 1643833009472798720
score 13.211869

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