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Impact of total activity variation in 18F-FDG injected with the overall PET image quality in oncology patients

The preliminary study aims to investigate whether variation on dose activity 18F -FDG will influence the overall PET image quality in oncology patients. This is a retrospective analysis of 10 oncology patients who were injected with an average of 337.40 ± 38.43 MBq of 18F -FDG for PET/CT whole body...

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Main Authors: Hassan, Muhammad Hishar, Ahmad Saad, Fathinul Fikri, Hitam, Salasiah, Mohd Noor, Noramaliza, Nordin, Abdul Jalil
Format: Conference or Workshop Item
Language:English
Published: AIP Publishing LLC 2012
Online Access:http://psasir.upm.edu.my/id/eprint/41271/1/Impact%20of%20total%20activity%20variation%20in%2018F-FDG%20injected%20with%20the%20overall%20PET%20image%20quality%20in%20oncology%20patients.pdf
http://psasir.upm.edu.my/id/eprint/41271/
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spelling my.upm.eprints.412712017-09-11T04:30:29Z http://psasir.upm.edu.my/id/eprint/41271/ Impact of total activity variation in 18F-FDG injected with the overall PET image quality in oncology patients Hassan, Muhammad Hishar Ahmad Saad, Fathinul Fikri Hitam, Salasiah Mohd Noor, Noramaliza Nordin, Abdul Jalil The preliminary study aims to investigate whether variation on dose activity 18F -FDG will influence the overall PET image quality in oncology patients. This is a retrospective analysis of 10 oncology patients who were injected with an average of 337.40 ± 38.43 MBq of 18F -FDG for PET/CT whole body examination. Patients were divided into 2 groups based on total activity of 18F -FDG injected: less than 333 MBq (302.96±12.65 MBq) (group 1) and more than 333 MBq (371.85±14.00 MBq) (group 2). Multiple Image Projection (MIP) PET images were scored visually by two qualified nuclear radiologists using a two-point scoring scale (poor and excellent). The agreement between radiologists was analysed using kappa measure of agreement (K). The prediction on poor-to-excellent PET image by the total activity of 18F-FDG injected was analysed using a Chi-squared test (x 2). A p value of < 0.05 was considered significant. Agreement on PET image scoring was substantial, with a kappa value of 0.737. However, the prediction of the PET image quality by the total activity injected has been found to be insignificant (p > 0.05). Therefore, there is no strong evidence suggest that the dose injected will influence the PET image quality. Hence, it is recommended to use low-dosed of 18F -FDG technique as it also potentially yields a comparable PET image and reduces radiation burden to the patients. AIP Publishing LLC 2012 Conference or Workshop Item PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/41271/1/Impact%20of%20total%20activity%20variation%20in%2018F-FDG%20injected%20with%20the%20overall%20PET%20image%20quality%20in%20oncology%20patients.pdf Hassan, Muhammad Hishar and Ahmad Saad, Fathinul Fikri and Hitam, Salasiah and Mohd Noor, Noramaliza and Nordin, Abdul Jalil (2012) Impact of total activity variation in 18F-FDG injected with the overall PET image quality in oncology patients. In: 2012 National Physics Conference (PERFIK 2012), 19-21 Nov. 2012, Colmar Tropicale, Bukit Tinggi, Pahang, Malaysia. (pp. 412-416). 10.1063/1.4803636
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The preliminary study aims to investigate whether variation on dose activity 18F -FDG will influence the overall PET image quality in oncology patients. This is a retrospective analysis of 10 oncology patients who were injected with an average of 337.40 ± 38.43 MBq of 18F -FDG for PET/CT whole body examination. Patients were divided into 2 groups based on total activity of 18F -FDG injected: less than 333 MBq (302.96±12.65 MBq) (group 1) and more than 333 MBq (371.85±14.00 MBq) (group 2). Multiple Image Projection (MIP) PET images were scored visually by two qualified nuclear radiologists using a two-point scoring scale (poor and excellent). The agreement between radiologists was analysed using kappa measure of agreement (K). The prediction on poor-to-excellent PET image by the total activity of 18F-FDG injected was analysed using a Chi-squared test (x 2). A p value of < 0.05 was considered significant. Agreement on PET image scoring was substantial, with a kappa value of 0.737. However, the prediction of the PET image quality by the total activity injected has been found to be insignificant (p > 0.05). Therefore, there is no strong evidence suggest that the dose injected will influence the PET image quality. Hence, it is recommended to use low-dosed of 18F -FDG technique as it also potentially yields a comparable PET image and reduces radiation burden to the patients.
format Conference or Workshop Item
author Hassan, Muhammad Hishar
Ahmad Saad, Fathinul Fikri
Hitam, Salasiah
Mohd Noor, Noramaliza
Nordin, Abdul Jalil
spellingShingle Hassan, Muhammad Hishar
Ahmad Saad, Fathinul Fikri
Hitam, Salasiah
Mohd Noor, Noramaliza
Nordin, Abdul Jalil
Impact of total activity variation in 18F-FDG injected with the overall PET image quality in oncology patients
author_facet Hassan, Muhammad Hishar
Ahmad Saad, Fathinul Fikri
Hitam, Salasiah
Mohd Noor, Noramaliza
Nordin, Abdul Jalil
author_sort Hassan, Muhammad Hishar
title Impact of total activity variation in 18F-FDG injected with the overall PET image quality in oncology patients
title_short Impact of total activity variation in 18F-FDG injected with the overall PET image quality in oncology patients
title_full Impact of total activity variation in 18F-FDG injected with the overall PET image quality in oncology patients
title_fullStr Impact of total activity variation in 18F-FDG injected with the overall PET image quality in oncology patients
title_full_unstemmed Impact of total activity variation in 18F-FDG injected with the overall PET image quality in oncology patients
title_sort impact of total activity variation in 18f-fdg injected with the overall pet image quality in oncology patients
publisher AIP Publishing LLC
publishDate 2012
url http://psasir.upm.edu.my/id/eprint/41271/1/Impact%20of%20total%20activity%20variation%20in%2018F-FDG%20injected%20with%20the%20overall%20PET%20image%20quality%20in%20oncology%20patients.pdf
http://psasir.upm.edu.my/id/eprint/41271/
_version_ 1643832950058385408
score 13.211869

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