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Genetic polymorphisms and drug interactions leading to clopidogrel resistance: why the Asian population requires special attention

Ischemic heart disease and stroke are the two leading causes of death worldwide. Antiplatelet therapy plays the most significant role in the management of these cardiovascular and cerebrovascular occlusive events to prevent recurrent ischemic attack. Clopidogrel, an antiplatelet drug, is widely pres...

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Main Authors: Hasan, Md. Shariful, Basri, Hamidon, Lim, Poh Hin, Stanslas, Johnson
Format: Article
Language:English
Published: Informa Healthcare 2013
Online Access:http://psasir.upm.edu.my/id/eprint/40431/1/Genetic%20polymorphisms%20and%20drug%20interactions%20leading%20to%20clopidogrel%20resistance%20why%20the%20Asian%20population%20requires%20special%20attention.pdf
http://psasir.upm.edu.my/id/eprint/40431/
http://www.tandfonline.com/doi/abs/10.3109/00207454.2012.744308?journalCode=ines20
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spelling my.upm.eprints.404312015-09-18T02:52:17Z http://psasir.upm.edu.my/id/eprint/40431/ Genetic polymorphisms and drug interactions leading to clopidogrel resistance: why the Asian population requires special attention Hasan, Md. Shariful Basri, Hamidon Lim, Poh Hin Stanslas, Johnson Ischemic heart disease and stroke are the two leading causes of death worldwide. Antiplatelet therapy plays the most significant role in the management of these cardiovascular and cerebrovascular occlusive events to prevent recurrent ischemic attack. Clopidogrel, an antiplatelet drug, is widely prescribed either alone or in combination with aspirin as dual antiplatelet therapy for the prevention of vascular occlusive events. The antiplatelet response to clopidogrel varies widely. Hyporesponders and nonresponders are likely to have adverse cardiovascular events during follow-up. Some drugs, such as proton pump inhibitors (omeprazole), calcium channel blockers, selective serotonin reuptake inhibitors (nefazadone), coumarin derivatives (phenprocoumon), benzodiazepines, sulfonylurea, erythromycin, and itraconazole, decrease the antiplatelet effect of clopidogrel when administered concomitantly. Decreased response to clopidogrel is common among Asians due to genetic polymorphisms associated with clopidogrel resistance, and it is nearly 70% in some of the Asian communities. It is necessary to study Asian populations, because there are a large number of Asians throughout the world due to increased migration. Current guidelines do not make genetic testing or platelet response testing mandatory prior to clopidogrel prescription. Therefore, it is important for clinicians treating Asian patients to keep in mind the interindividual variability in response to clopidogrel when prescribing the drug. Informa Healthcare 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40431/1/Genetic%20polymorphisms%20and%20drug%20interactions%20leading%20to%20clopidogrel%20resistance%20why%20the%20Asian%20population%20requires%20special%20attention.pdf Hasan, Md. Shariful and Basri, Hamidon and Lim, Poh Hin and Stanslas, Johnson (2013) Genetic polymorphisms and drug interactions leading to clopidogrel resistance: why the Asian population requires special attention. International Journal of Neuroscience, 123 (3). pp. 143-154. ISSN 0020-7454; ESSN: 1563-5279 http://www.tandfonline.com/doi/abs/10.3109/00207454.2012.744308?journalCode=ines20 10.3109/00207454.2012.744308
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Ischemic heart disease and stroke are the two leading causes of death worldwide. Antiplatelet therapy plays the most significant role in the management of these cardiovascular and cerebrovascular occlusive events to prevent recurrent ischemic attack. Clopidogrel, an antiplatelet drug, is widely prescribed either alone or in combination with aspirin as dual antiplatelet therapy for the prevention of vascular occlusive events. The antiplatelet response to clopidogrel varies widely. Hyporesponders and nonresponders are likely to have adverse cardiovascular events during follow-up. Some drugs, such as proton pump inhibitors (omeprazole), calcium channel blockers, selective serotonin reuptake inhibitors (nefazadone), coumarin derivatives (phenprocoumon), benzodiazepines, sulfonylurea, erythromycin, and itraconazole, decrease the antiplatelet effect of clopidogrel when administered concomitantly. Decreased response to clopidogrel is common among Asians due to genetic polymorphisms associated with clopidogrel resistance, and it is nearly 70% in some of the Asian communities. It is necessary to study Asian populations, because there are a large number of Asians throughout the world due to increased migration. Current guidelines do not make genetic testing or platelet response testing mandatory prior to clopidogrel prescription. Therefore, it is important for clinicians treating Asian patients to keep in mind the interindividual variability in response to clopidogrel when prescribing the drug.
format Article
author Hasan, Md. Shariful
Basri, Hamidon
Lim, Poh Hin
Stanslas, Johnson
spellingShingle Hasan, Md. Shariful
Basri, Hamidon
Lim, Poh Hin
Stanslas, Johnson
Genetic polymorphisms and drug interactions leading to clopidogrel resistance: why the Asian population requires special attention
author_facet Hasan, Md. Shariful
Basri, Hamidon
Lim, Poh Hin
Stanslas, Johnson
author_sort Hasan, Md. Shariful
title Genetic polymorphisms and drug interactions leading to clopidogrel resistance: why the Asian population requires special attention
title_short Genetic polymorphisms and drug interactions leading to clopidogrel resistance: why the Asian population requires special attention
title_full Genetic polymorphisms and drug interactions leading to clopidogrel resistance: why the Asian population requires special attention
title_fullStr Genetic polymorphisms and drug interactions leading to clopidogrel resistance: why the Asian population requires special attention
title_full_unstemmed Genetic polymorphisms and drug interactions leading to clopidogrel resistance: why the Asian population requires special attention
title_sort genetic polymorphisms and drug interactions leading to clopidogrel resistance: why the asian population requires special attention
publisher Informa Healthcare
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/40431/1/Genetic%20polymorphisms%20and%20drug%20interactions%20leading%20to%20clopidogrel%20resistance%20why%20the%20Asian%20population%20requires%20special%20attention.pdf
http://psasir.upm.edu.my/id/eprint/40431/
http://www.tandfonline.com/doi/abs/10.3109/00207454.2012.744308?journalCode=ines20
_version_ 1643832714162339840
score 13.244413

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