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Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations

As multiple sclerosis (MS) has long been known to be associated with Leber, hereditary optic neuropathy (LHON), a disease caused by mitochondrial (mtDNA) mutations, in this study we assessed possible involvement of mtDNA point mutation in MS patients. Fifty-two MS patients whose disease was confirme...

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Main Authors: Ghabaee, Mojdeh, Omranisikaroudi, Motahar, Amrisaroukolaei, Shahla, Meysamie, Alipasha, Sahraian, Mohammad Ali, Bayati, Asghar, Sanati, Mohammad Hossein, Houshman, Mossoud, Sadeghian, Homa, Vajihazaman, Khalili
Format: Article
Language:English
Published: Springer 2009
Online Access:http://psasir.upm.edu.my/id/eprint/40430/1/Mitochondrial%20mutation%20in%20iranian%20patients%20with%20multiple%20sclerosis%2C%20correlation%20between%20haplogroups%20H%2C%20A%20and%20clinical%20manifestations.pdf
http://psasir.upm.edu.my/id/eprint/40430/
http://link.springer.com/article/10.1007%2Fs10571-008-9325-7
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spelling my.upm.eprints.404302015-09-18T02:48:30Z http://psasir.upm.edu.my/id/eprint/40430/ Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations Ghabaee, Mojdeh Omranisikaroudi, Motahar Amrisaroukolaei, Shahla Meysamie, Alipasha Sahraian, Mohammad Ali Bayati, Asghar Sanati, Mohammad Hossein Houshman, Mossoud Sadeghian, Homa Vajihazaman, Khalili As multiple sclerosis (MS) has long been known to be associated with Leber, hereditary optic neuropathy (LHON), a disease caused by mitochondrial (mtDNA) mutations, in this study we assessed possible involvement of mtDNA point mutation in MS patients. Fifty-two MS patients whose disease was confirmed with revised McDonald criteria and referred to Iranian Center of Neurological Research of Imam Khomeini hospital during 2006–2007 entered the study. Secondary mtDNA mutations, age, gender, clinical disability according to expanded disability status scale (EDSS), course of the disease, and presenting symptoms were the variables investigated in this study. DNA purification was performed by Diatom DNA Extraction Kit. Analysis of data was done by SPSS V11.5. The prevalent mutations with frequency of 19.2% were J, L, and T haplogroups. Haplotype A was more prevalent in patients with younger age of onset (P-value = 0.012) and high proportion of haplogroup H was associated with optic nerve involvement (P-value = 0.015). No motor symptoms were seen in haplogroup H patients. There is no significant relationship between duration of the disease and EDSS in different mutation of mtDNA. Springer 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40430/1/Mitochondrial%20mutation%20in%20iranian%20patients%20with%20multiple%20sclerosis%2C%20correlation%20between%20haplogroups%20H%2C%20A%20and%20clinical%20manifestations.pdf Ghabaee, Mojdeh and Omranisikaroudi, Motahar and Amrisaroukolaei, Shahla and Meysamie, Alipasha and Sahraian, Mohammad Ali and Bayati, Asghar and Sanati, Mohammad Hossein and Houshman, Mossoud and Sadeghian, Homa and Vajihazaman, Khalili (2009) Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations. Cellular and Molecular Neurobiology, 29 (3). pp. 341-346. ISSN 0272-4340; ESSN: 1573-6830 http://link.springer.com/article/10.1007%2Fs10571-008-9325-7 10.1007/s10571-008-9325-7
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description As multiple sclerosis (MS) has long been known to be associated with Leber, hereditary optic neuropathy (LHON), a disease caused by mitochondrial (mtDNA) mutations, in this study we assessed possible involvement of mtDNA point mutation in MS patients. Fifty-two MS patients whose disease was confirmed with revised McDonald criteria and referred to Iranian Center of Neurological Research of Imam Khomeini hospital during 2006–2007 entered the study. Secondary mtDNA mutations, age, gender, clinical disability according to expanded disability status scale (EDSS), course of the disease, and presenting symptoms were the variables investigated in this study. DNA purification was performed by Diatom DNA Extraction Kit. Analysis of data was done by SPSS V11.5. The prevalent mutations with frequency of 19.2% were J, L, and T haplogroups. Haplotype A was more prevalent in patients with younger age of onset (P-value = 0.012) and high proportion of haplogroup H was associated with optic nerve involvement (P-value = 0.015). No motor symptoms were seen in haplogroup H patients. There is no significant relationship between duration of the disease and EDSS in different mutation of mtDNA.
format Article
author Ghabaee, Mojdeh
Omranisikaroudi, Motahar
Amrisaroukolaei, Shahla
Meysamie, Alipasha
Sahraian, Mohammad Ali
Bayati, Asghar
Sanati, Mohammad Hossein
Houshman, Mossoud
Sadeghian, Homa
Vajihazaman, Khalili
spellingShingle Ghabaee, Mojdeh
Omranisikaroudi, Motahar
Amrisaroukolaei, Shahla
Meysamie, Alipasha
Sahraian, Mohammad Ali
Bayati, Asghar
Sanati, Mohammad Hossein
Houshman, Mossoud
Sadeghian, Homa
Vajihazaman, Khalili
Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations
author_facet Ghabaee, Mojdeh
Omranisikaroudi, Motahar
Amrisaroukolaei, Shahla
Meysamie, Alipasha
Sahraian, Mohammad Ali
Bayati, Asghar
Sanati, Mohammad Hossein
Houshman, Mossoud
Sadeghian, Homa
Vajihazaman, Khalili
author_sort Ghabaee, Mojdeh
title Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations
title_short Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations
title_full Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations
title_fullStr Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations
title_full_unstemmed Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations
title_sort mitochondrial mutation in iranian patients with multiple sclerosis, correlation between haplogroups h, a and clinical manifestations
publisher Springer
publishDate 2009
url http://psasir.upm.edu.my/id/eprint/40430/1/Mitochondrial%20mutation%20in%20iranian%20patients%20with%20multiple%20sclerosis%2C%20correlation%20between%20haplogroups%20H%2C%20A%20and%20clinical%20manifestations.pdf
http://psasir.upm.edu.my/id/eprint/40430/
http://link.springer.com/article/10.1007%2Fs10571-008-9325-7
_version_ 1643832713865592832
score 13.211869

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