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Serotonin transporter polymorphisms and clinical response to sertraline across ethnicities

The aim of this pilot study was to examine the relationship between clinical response, adverse effects, sertraline (SERT) plasma concentrations and the genetic polymorphism of the serotonin transporter gene-linked polymorphic region (5HTTLPR) in 2 ethnic patient groups. The study involved 45 patient...

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Main Authors: Ng, Chee Hong, Easteal, Simon, Tan, Susan, Schweitzer, Isaac, Kong, Brian Wai Ho, Aziz, Salina
Format: Article
Language:English
Published: Elsevier 2006
Online Access:http://psasir.upm.edu.my/id/eprint/40421/1/Serotonin%20transporter%20polymorphisms%20and%20clinical%20response%20to%20sertraline%20across%20ethnicities.pdf
http://psasir.upm.edu.my/id/eprint/40421/
http://www.sciencedirect.com/science/article/pii/S027858460600073X
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spelling my.upm.eprints.404212015-09-18T02:13:27Z http://psasir.upm.edu.my/id/eprint/40421/ Serotonin transporter polymorphisms and clinical response to sertraline across ethnicities Ng, Chee Hong Easteal, Simon Tan, Susan Schweitzer, Isaac Kong, Brian Wai Ho Aziz, Salina The aim of this pilot study was to examine the relationship between clinical response, adverse effects, sertraline (SERT) plasma concentrations and the genetic polymorphism of the serotonin transporter gene-linked polymorphic region (5HTTLPR) in 2 ethnic patient groups. The study involved 45 patients in a clinical trial who received a fixed dose regimen of 50 mg SERT for one week, then a variable-dose regimen for a further 6 weeks for major depressive disorder. At weeks 1 and 6, the following assessments were completed: Hamilton Depression Rating Scale (HDRS), Clinical Global Impression (CGI), drug adverse reaction scale and measurement of plasma SERT levels. Genomic analysis for the long and short allele variants of the 5HTTLPR polymorphism was also carried out. Caucasian subjects had a higher rate of l/l genotype while Chinese subjects had higher frequencies of l/s and s/s genotypes. Comparison of the subjects with the 5HTTLPR s/s genotype and those with the l/l and l/s genotypes found no significant differences in the HDRS scores, CGI scores, response rates, adverse effects and SERT plasma concentrations at week 6. Elsevier 2006-07 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40421/1/Serotonin%20transporter%20polymorphisms%20and%20clinical%20response%20to%20sertraline%20across%20ethnicities.pdf Ng, Chee Hong and Easteal, Simon and Tan, Susan and Schweitzer, Isaac and Kong, Brian Wai Ho and Aziz, Salina (2006) Serotonin transporter polymorphisms and clinical response to sertraline across ethnicities. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 30 (5). pp. 953-957. ISSN 0278-5846; ESSN: 1878-4216 http://www.sciencedirect.com/science/article/pii/S027858460600073X 10.1016/j.pnpbp.2006.02.015
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The aim of this pilot study was to examine the relationship between clinical response, adverse effects, sertraline (SERT) plasma concentrations and the genetic polymorphism of the serotonin transporter gene-linked polymorphic region (5HTTLPR) in 2 ethnic patient groups. The study involved 45 patients in a clinical trial who received a fixed dose regimen of 50 mg SERT for one week, then a variable-dose regimen for a further 6 weeks for major depressive disorder. At weeks 1 and 6, the following assessments were completed: Hamilton Depression Rating Scale (HDRS), Clinical Global Impression (CGI), drug adverse reaction scale and measurement of plasma SERT levels. Genomic analysis for the long and short allele variants of the 5HTTLPR polymorphism was also carried out. Caucasian subjects had a higher rate of l/l genotype while Chinese subjects had higher frequencies of l/s and s/s genotypes. Comparison of the subjects with the 5HTTLPR s/s genotype and those with the l/l and l/s genotypes found no significant differences in the HDRS scores, CGI scores, response rates, adverse effects and SERT plasma concentrations at week 6.
format Article
author Ng, Chee Hong
Easteal, Simon
Tan, Susan
Schweitzer, Isaac
Kong, Brian Wai Ho
Aziz, Salina
spellingShingle Ng, Chee Hong
Easteal, Simon
Tan, Susan
Schweitzer, Isaac
Kong, Brian Wai Ho
Aziz, Salina
Serotonin transporter polymorphisms and clinical response to sertraline across ethnicities
author_facet Ng, Chee Hong
Easteal, Simon
Tan, Susan
Schweitzer, Isaac
Kong, Brian Wai Ho
Aziz, Salina
author_sort Ng, Chee Hong
title Serotonin transporter polymorphisms and clinical response to sertraline across ethnicities
title_short Serotonin transporter polymorphisms and clinical response to sertraline across ethnicities
title_full Serotonin transporter polymorphisms and clinical response to sertraline across ethnicities
title_fullStr Serotonin transporter polymorphisms and clinical response to sertraline across ethnicities
title_full_unstemmed Serotonin transporter polymorphisms and clinical response to sertraline across ethnicities
title_sort serotonin transporter polymorphisms and clinical response to sertraline across ethnicities
publisher Elsevier
publishDate 2006
url http://psasir.upm.edu.my/id/eprint/40421/1/Serotonin%20transporter%20polymorphisms%20and%20clinical%20response%20to%20sertraline%20across%20ethnicities.pdf
http://psasir.upm.edu.my/id/eprint/40421/
http://www.sciencedirect.com/science/article/pii/S027858460600073X
_version_ 1643832711192772608
score 13.211869

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