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Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats

The influence of copper (Cu) overload on hepatic lipid peroxidation and antioxidation defense capacity was studied by overloading rats with copper sulphate orally (500 mg Cu/kg bw) 5 d/w for 8 w. Malondialdehyde (MDA), Cu-Zn superoxide dismutase (SOD), and Se-glutathione peroxidase (GSH-Px) were mea...

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Main Authors: Zhang, S. S., Mohamed Mustapha, Noordin, Rahman, Shakilur O. A., Haron, Md. Jelas
Format: Article
Language:English
Published: American College of Veterinary Toxicologists 2000
Online Access:http://psasir.upm.edu.my/id/eprint/40378/1/Effects%20of%20copper%20overload%20on%20hepatic%20lipid%20peroxidation%20and%20antioxidant%20defense%20in%20rats.pdf
http://psasir.upm.edu.my/id/eprint/40378/
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spelling my.upm.eprints.403782016-11-21T07:10:39Z http://psasir.upm.edu.my/id/eprint/40378/ Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats Zhang, S. S. Mohamed Mustapha, Noordin Rahman, Shakilur O. A. Haron, Md. Jelas The influence of copper (Cu) overload on hepatic lipid peroxidation and antioxidation defense capacity was studied by overloading rats with copper sulphate orally (500 mg Cu/kg bw) 5 d/w for 8 w. Malondialdehyde (MDA), Cu-Zn superoxide dismutase (SOD), and Se-glutathione peroxidase (GSH-Px) were measured in serum and liver homogenate at 2, 4 and 8 w of dosing. Liver Cu concentration and alanine aminotransferase (ALT) activity were also determined. As Cu loading progressed, there were multiparameter changes with significant ALT elevation, increased MDA concentrations in serum and liver homogenate, and dramatic declines of SOD and GSH-Px activities in erythrocytes and whole blood respectively, along with marked elevation of hepatic Cu in the Cu-dosed group. Excessive Cu accumulation in the liver depressed SOD and GSH-Px activities and resulted in high MDA in serum and liver homogenate due to the lipid peroxidation induced by the Cu overload. American College of Veterinary Toxicologists 2000 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40378/1/Effects%20of%20copper%20overload%20on%20hepatic%20lipid%20peroxidation%20and%20antioxidant%20defense%20in%20rats.pdf Zhang, S. S. and Mohamed Mustapha, Noordin and Rahman, Shakilur O. A. and Haron, Md. Jelas (2000) Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats. Veterinary and Human Toxicology, 42 (5). pp. 261-264. ISSN 0145-6296
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The influence of copper (Cu) overload on hepatic lipid peroxidation and antioxidation defense capacity was studied by overloading rats with copper sulphate orally (500 mg Cu/kg bw) 5 d/w for 8 w. Malondialdehyde (MDA), Cu-Zn superoxide dismutase (SOD), and Se-glutathione peroxidase (GSH-Px) were measured in serum and liver homogenate at 2, 4 and 8 w of dosing. Liver Cu concentration and alanine aminotransferase (ALT) activity were also determined. As Cu loading progressed, there were multiparameter changes with significant ALT elevation, increased MDA concentrations in serum and liver homogenate, and dramatic declines of SOD and GSH-Px activities in erythrocytes and whole blood respectively, along with marked elevation of hepatic Cu in the Cu-dosed group. Excessive Cu accumulation in the liver depressed SOD and GSH-Px activities and resulted in high MDA in serum and liver homogenate due to the lipid peroxidation induced by the Cu overload.
format Article
author Zhang, S. S.
Mohamed Mustapha, Noordin
Rahman, Shakilur O. A.
Haron, Md. Jelas
spellingShingle Zhang, S. S.
Mohamed Mustapha, Noordin
Rahman, Shakilur O. A.
Haron, Md. Jelas
Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats
author_facet Zhang, S. S.
Mohamed Mustapha, Noordin
Rahman, Shakilur O. A.
Haron, Md. Jelas
author_sort Zhang, S. S.
title Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats
title_short Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats
title_full Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats
title_fullStr Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats
title_full_unstemmed Effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats
title_sort effects of copper overload on hepatic lipid peroxidation and antioxidant defense in rats
publisher American College of Veterinary Toxicologists
publishDate 2000
url http://psasir.upm.edu.my/id/eprint/40378/1/Effects%20of%20copper%20overload%20on%20hepatic%20lipid%20peroxidation%20and%20antioxidant%20defense%20in%20rats.pdf
http://psasir.upm.edu.my/id/eprint/40378/
_version_ 1643832699345960960
score 13.211869

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