Cover Image

The effect of Malaysian cocoa extract on glucose levels and lipid profiles in diabetic rats

The present study aims to investigate the effect of cocoa extract on serum glucose levels and lipid profiles in streptozotocin-diabetic rats. Cocoa extract (contained 285.6 mg total polyphenol per gram extract) was prepared from fermented and roasted (140 °C, 20 min) beans by extracting using 80% et...

Full description

Saved in:
Bibliographic Details
Main Authors: Mohd Mokhtar, Ruzaidi Azli, Ismail, Amin, Abdul Ghani, Nawalyah, Hamid, Muhajir, H. A., Faizul
Format: Article
Language:English
Published: Elsevier 2005
Online Access:http://psasir.upm.edu.my/id/eprint/40318/1/The%20effect%20of%20Malaysian%20cocoa%20extract%20on%20glucose%20levels%20and%20lipid%20profiles%20in%20diabetic%20rats.pdf
http://psasir.upm.edu.my/id/eprint/40318/
http://www.sciencedirect.com/science/article/pii/S0378874105000140#
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.40318
record_format eprints
spelling my.upm.eprints.403182015-09-17T01:08:05Z http://psasir.upm.edu.my/id/eprint/40318/ The effect of Malaysian cocoa extract on glucose levels and lipid profiles in diabetic rats Mohd Mokhtar, Ruzaidi Azli Ismail, Amin Abdul Ghani, Nawalyah Hamid, Muhajir H. A., Faizul The present study aims to investigate the effect of cocoa extract on serum glucose levels and lipid profiles in streptozotocin-diabetic rats. Cocoa extract (contained 285.6 mg total polyphenol per gram extract) was prepared from fermented and roasted (140 °C, 20 min) beans by extracting using 80% ethanol in the ratio of 1–10. The extract of three dosages (1, 2, and 3%) was fed to normal and diabetic rats for a period of 4 weeks. In hyperglycaemic group, cocoa extract (1 and 3%) diets were found to significantly lower (p < 0.05) the serum glucose levels compared to the control. Furthermore, supplementation of 1 and 3% cocoa extract had significantly reduced (p < 0.05) the level of total cholesterol in diabetic rats. In addition, 1, 2, and 3% cocoa extract diets had significantly lowered (p < 0.05) the total triglycerides. Interestingly, this study found that serum HDL-cholesterol had increased significantly (p < 0.05) in diabetic rats fed with 2% cocoa extract, while the LDL-cholesterol had decreased significantly (p < 0.05) in the 1% treated group. These results indicate that cocoa extract may possess potential hypoglycaemic and hypocholestrolemic effects on serum glucose levels and lipid profiles, respectively. The results also found that the effect of cocoa extract was dose-dependent. Elsevier 2005-04 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40318/1/The%20effect%20of%20Malaysian%20cocoa%20extract%20on%20glucose%20levels%20and%20lipid%20profiles%20in%20diabetic%20rats.pdf Mohd Mokhtar, Ruzaidi Azli and Ismail, Amin and Abdul Ghani, Nawalyah and Hamid, Muhajir and H. A., Faizul (2005) The effect of Malaysian cocoa extract on glucose levels and lipid profiles in diabetic rats. Journal of Ethnopharmacology, 98 (1-2). pp. 55-60. ISSN 0378-8741; ESSN: 1872-7573 http://www.sciencedirect.com/science/article/pii/S0378874105000140# 10.1016/j.jep.2004.12.018
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The present study aims to investigate the effect of cocoa extract on serum glucose levels and lipid profiles in streptozotocin-diabetic rats. Cocoa extract (contained 285.6 mg total polyphenol per gram extract) was prepared from fermented and roasted (140 °C, 20 min) beans by extracting using 80% ethanol in the ratio of 1–10. The extract of three dosages (1, 2, and 3%) was fed to normal and diabetic rats for a period of 4 weeks. In hyperglycaemic group, cocoa extract (1 and 3%) diets were found to significantly lower (p < 0.05) the serum glucose levels compared to the control. Furthermore, supplementation of 1 and 3% cocoa extract had significantly reduced (p < 0.05) the level of total cholesterol in diabetic rats. In addition, 1, 2, and 3% cocoa extract diets had significantly lowered (p < 0.05) the total triglycerides. Interestingly, this study found that serum HDL-cholesterol had increased significantly (p < 0.05) in diabetic rats fed with 2% cocoa extract, while the LDL-cholesterol had decreased significantly (p < 0.05) in the 1% treated group. These results indicate that cocoa extract may possess potential hypoglycaemic and hypocholestrolemic effects on serum glucose levels and lipid profiles, respectively. The results also found that the effect of cocoa extract was dose-dependent.
format Article
author Mohd Mokhtar, Ruzaidi Azli
Ismail, Amin
Abdul Ghani, Nawalyah
Hamid, Muhajir
H. A., Faizul
spellingShingle Mohd Mokhtar, Ruzaidi Azli
Ismail, Amin
Abdul Ghani, Nawalyah
Hamid, Muhajir
H. A., Faizul
The effect of Malaysian cocoa extract on glucose levels and lipid profiles in diabetic rats
author_facet Mohd Mokhtar, Ruzaidi Azli
Ismail, Amin
Abdul Ghani, Nawalyah
Hamid, Muhajir
H. A., Faizul
author_sort Mohd Mokhtar, Ruzaidi Azli
title The effect of Malaysian cocoa extract on glucose levels and lipid profiles in diabetic rats
title_short The effect of Malaysian cocoa extract on glucose levels and lipid profiles in diabetic rats
title_full The effect of Malaysian cocoa extract on glucose levels and lipid profiles in diabetic rats
title_fullStr The effect of Malaysian cocoa extract on glucose levels and lipid profiles in diabetic rats
title_full_unstemmed The effect of Malaysian cocoa extract on glucose levels and lipid profiles in diabetic rats
title_sort effect of malaysian cocoa extract on glucose levels and lipid profiles in diabetic rats
publisher Elsevier
publishDate 2005
url http://psasir.upm.edu.my/id/eprint/40318/1/The%20effect%20of%20Malaysian%20cocoa%20extract%20on%20glucose%20levels%20and%20lipid%20profiles%20in%20diabetic%20rats.pdf
http://psasir.upm.edu.my/id/eprint/40318/
http://www.sciencedirect.com/science/article/pii/S0378874105000140#
_version_ 1643832681381756928
score 13.211869

Similar Items