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High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study)

A total of 685 clinical Streptococcus pneumoniae isolates from patients with pneumococcal diseases were collected from 14 centers in 11 Asian countries from January 2000 to June 2001. The in vitro susceptibilities of the isolates to 14 antimicrobial agents were determined by the broth microdilution...

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Main Authors: Song, Jae Hoon, Jung, Sook In, Ko, Kwan Soo, Kim, Na Young, Son, Jun Seong, Chang, Hyun Ha, Ki, Hyun Kyun, Oh, Won Sup, Suh, Ji Yoeun, Peck, Kyong Ran, Lee, Nam Yong, Yang, Yonghong, Lu, Quan, Chongthaleong, Anan, Chiu, Cheng Hsun, Lalitha, Mukkai Kesavan, Perera, Jennifer A., Yee, Ti Teow, Kumarasinghe, Gamini, Jamal, Farida, Kamarulzaman, Adeeba, Parasakthi, Navaratnam, Van Hung, Pham, Carlos, Celia Carpio, So, Thomas Man-Kit, Ng, Tak Keung, Shibl, Atef M.
Format: Article
Language:English
Published: American Society for Microbiology 2004
Online Access:http://psasir.upm.edu.my/id/eprint/40040/1/High%20prevalence%20of%20antimicrobial%20resistance%20among%20clinical%20Streptococcus%20pneumoniae%20isolates%20in%20Asia%20%28an%20ANSORP%20study%29.pdf
http://psasir.upm.edu.my/id/eprint/40040/
http://aac.asm.org/content/48/6/2101.abstract
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spelling my.upm.eprints.400402015-08-27T01:10:04Z http://psasir.upm.edu.my/id/eprint/40040/ High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study) Song, Jae Hoon Jung, Sook In Ko, Kwan Soo Kim, Na Young Son, Jun Seong Chang, Hyun Ha Ki, Hyun Kyun Oh, Won Sup Suh, Ji Yoeun Peck, Kyong Ran Lee, Nam Yong Yang, Yonghong Lu, Quan Chongthaleong, Anan Chiu, Cheng Hsun Lalitha, Mukkai Kesavan Perera, Jennifer A. Yee, Ti Teow Kumarasinghe, Gamini Jamal, Farida Kamarulzaman, Adeeba Parasakthi, Navaratnam Van Hung, Pham Carlos, Celia Carpio So, Thomas Man-Kit Ng, Tak Keung Shibl, Atef M. A total of 685 clinical Streptococcus pneumoniae isolates from patients with pneumococcal diseases were collected from 14 centers in 11 Asian countries from January 2000 to June 2001. The in vitro susceptibilities of the isolates to 14 antimicrobial agents were determined by the broth microdilution test. Among the isolates tested, 483 (52.4%) were not susceptible to penicillin, 23% were intermediate, and 29.4% were penicillin resistant (MICs ≥ 2 mg/liter). Isolates from Vietnam showed the highest prevalence of penicillin resistance (71.4%), followed by those from Korea (54.8%), Hong Kong (43.2%), and Taiwan (38.6%). The penicillin MICs at which 90% of isolates are inhibited (MIC90s) were 4 mg/liter among isolates from Vietnam, Hong Kong, Korea, and Taiwan. The prevalence of erythromycin resistance was also very high in Vietnam (92.1%), Taiwan (86%), Korea (80.6%), Hong Kong (76.8%), and China (73.9%). The MIC90s of erythromycin were >32 mg/liter among isolates from Korea, Vietnam, China, Taiwan, Singapore, Malaysia, and Hong Kong. Isolates from Hong Kong showed the highest rate of ciprofloxacin resistance (11.8%), followed by isolates from Sri Lanka (9.5%), the Philippines (9.1%), and Korea (6.5%). Multilocus sequence typing showed that the spread of the Taiwan19F clone and the Spain23F clone could be one of the major reasons for the rapid increases in antimicrobial resistance among S. pneumoniae isolates in Asia. Data from the multinational surveillance study clearly documented distinctive increases in the prevalence rates and the levels of antimicrobial resistance among S. pneumoniae isolates in many Asian countries, which are among the highest in the world published to date. American Society for Microbiology 2004-06 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40040/1/High%20prevalence%20of%20antimicrobial%20resistance%20among%20clinical%20Streptococcus%20pneumoniae%20isolates%20in%20Asia%20%28an%20ANSORP%20study%29.pdf Song, Jae Hoon and Jung, Sook In and Ko, Kwan Soo and Kim, Na Young and Son, Jun Seong and Chang, Hyun Ha and Ki, Hyun Kyun and Oh, Won Sup and Suh, Ji Yoeun and Peck, Kyong Ran and Lee, Nam Yong and Yang, Yonghong and Lu, Quan and Chongthaleong, Anan and Chiu, Cheng Hsun and Lalitha, Mukkai Kesavan and Perera, Jennifer A. and Yee, Ti Teow and Kumarasinghe, Gamini and Jamal, Farida and Kamarulzaman, Adeeba and Parasakthi, Navaratnam and Van Hung, Pham and Carlos, Celia Carpio and So, Thomas Man-Kit and Ng, Tak Keung and Shibl, Atef M. (2004) High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study). Antimicrobial Agents and Chemotherapy, 48 (6). pp. 2101-2107. ISSN 0066-4804; ESSN: 1098-6596 http://aac.asm.org/content/48/6/2101.abstract 10.1128/AAC.48.6.2101-2107.2004
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description A total of 685 clinical Streptococcus pneumoniae isolates from patients with pneumococcal diseases were collected from 14 centers in 11 Asian countries from January 2000 to June 2001. The in vitro susceptibilities of the isolates to 14 antimicrobial agents were determined by the broth microdilution test. Among the isolates tested, 483 (52.4%) were not susceptible to penicillin, 23% were intermediate, and 29.4% were penicillin resistant (MICs ≥ 2 mg/liter). Isolates from Vietnam showed the highest prevalence of penicillin resistance (71.4%), followed by those from Korea (54.8%), Hong Kong (43.2%), and Taiwan (38.6%). The penicillin MICs at which 90% of isolates are inhibited (MIC90s) were 4 mg/liter among isolates from Vietnam, Hong Kong, Korea, and Taiwan. The prevalence of erythromycin resistance was also very high in Vietnam (92.1%), Taiwan (86%), Korea (80.6%), Hong Kong (76.8%), and China (73.9%). The MIC90s of erythromycin were >32 mg/liter among isolates from Korea, Vietnam, China, Taiwan, Singapore, Malaysia, and Hong Kong. Isolates from Hong Kong showed the highest rate of ciprofloxacin resistance (11.8%), followed by isolates from Sri Lanka (9.5%), the Philippines (9.1%), and Korea (6.5%). Multilocus sequence typing showed that the spread of the Taiwan19F clone and the Spain23F clone could be one of the major reasons for the rapid increases in antimicrobial resistance among S. pneumoniae isolates in Asia. Data from the multinational surveillance study clearly documented distinctive increases in the prevalence rates and the levels of antimicrobial resistance among S. pneumoniae isolates in many Asian countries, which are among the highest in the world published to date.
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author Song, Jae Hoon
Jung, Sook In
Ko, Kwan Soo
Kim, Na Young
Son, Jun Seong
Chang, Hyun Ha
Ki, Hyun Kyun
Oh, Won Sup
Suh, Ji Yoeun
Peck, Kyong Ran
Lee, Nam Yong
Yang, Yonghong
Lu, Quan
Chongthaleong, Anan
Chiu, Cheng Hsun
Lalitha, Mukkai Kesavan
Perera, Jennifer A.
Yee, Ti Teow
Kumarasinghe, Gamini
Jamal, Farida
Kamarulzaman, Adeeba
Parasakthi, Navaratnam
Van Hung, Pham
Carlos, Celia Carpio
So, Thomas Man-Kit
Ng, Tak Keung
Shibl, Atef M.
spellingShingle Song, Jae Hoon
Jung, Sook In
Ko, Kwan Soo
Kim, Na Young
Son, Jun Seong
Chang, Hyun Ha
Ki, Hyun Kyun
Oh, Won Sup
Suh, Ji Yoeun
Peck, Kyong Ran
Lee, Nam Yong
Yang, Yonghong
Lu, Quan
Chongthaleong, Anan
Chiu, Cheng Hsun
Lalitha, Mukkai Kesavan
Perera, Jennifer A.
Yee, Ti Teow
Kumarasinghe, Gamini
Jamal, Farida
Kamarulzaman, Adeeba
Parasakthi, Navaratnam
Van Hung, Pham
Carlos, Celia Carpio
So, Thomas Man-Kit
Ng, Tak Keung
Shibl, Atef M.
High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study)
author_facet Song, Jae Hoon
Jung, Sook In
Ko, Kwan Soo
Kim, Na Young
Son, Jun Seong
Chang, Hyun Ha
Ki, Hyun Kyun
Oh, Won Sup
Suh, Ji Yoeun
Peck, Kyong Ran
Lee, Nam Yong
Yang, Yonghong
Lu, Quan
Chongthaleong, Anan
Chiu, Cheng Hsun
Lalitha, Mukkai Kesavan
Perera, Jennifer A.
Yee, Ti Teow
Kumarasinghe, Gamini
Jamal, Farida
Kamarulzaman, Adeeba
Parasakthi, Navaratnam
Van Hung, Pham
Carlos, Celia Carpio
So, Thomas Man-Kit
Ng, Tak Keung
Shibl, Atef M.
author_sort Song, Jae Hoon
title High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study)
title_short High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study)
title_full High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study)
title_fullStr High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study)
title_full_unstemmed High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study)
title_sort high prevalence of antimicrobial resistance among clinical streptococcus pneumoniae isolates in asia (an ansorp study)
publisher American Society for Microbiology
publishDate 2004
url http://psasir.upm.edu.my/id/eprint/40040/1/High%20prevalence%20of%20antimicrobial%20resistance%20among%20clinical%20Streptococcus%20pneumoniae%20isolates%20in%20Asia%20%28an%20ANSORP%20study%29.pdf
http://psasir.upm.edu.my/id/eprint/40040/
http://aac.asm.org/content/48/6/2101.abstract
_version_ 1643832599280353280
score 13.211869

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