Staff View: Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages

Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages

The mitochondrial DNA (mtDNA) sequence variation of the South American Ticuna, the Central American Maya, and the North American Pima was analyzed by restriction-endonuclease digestion and oligonucleotide hybridization. The analysis revealed that Amerindian populations have high frequencies of mtDNA...

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Main Authors:	Schurr, Theodore G., Ballinger, Scott W., Gan, Yik Yuen, Hodge, Judith A., Merriwether, David Andrew, Lawrence, Dale N., Knowler, William C., Weiss, Kenneth M., Wallace, Douglas C.
Format:	Article
Language:	English
Published:	American Society of Human Genetic 1990
Online Access:	http://psasir.upm.edu.my/id/eprint/40020/1/Amerindian%20mitochondrial%20DNAs%20have%20rare%20Asian%20mutations%20at%20high%20frequencies%2C%20suggesting%20they%20derived%20from%20four%20primary%20maternal%20lineages.pdf http://psasir.upm.edu.my/id/eprint/40020/
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id	my.upm.eprints.40020
record_format	eprints
spelling	my.upm.eprints.400202015-08-26T06:19:41Z http://psasir.upm.edu.my/id/eprint/40020/ Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages Schurr, Theodore G. Ballinger, Scott W. Gan, Yik Yuen Hodge, Judith A. Merriwether, David Andrew Lawrence, Dale N. Knowler, William C. Weiss, Kenneth M. Wallace, Douglas C. The mitochondrial DNA (mtDNA) sequence variation of the South American Ticuna, the Central American Maya, and the North American Pima was analyzed by restriction-endonuclease digestion and oligonucleotide hybridization. The analysis revealed that Amerindian populations have high frequencies of mtDNAs containing the rare Asian RFLP HincII morph 6, a rare HaeIII site gain, and a unique AluI site gain. In addition, the Asian-specific deletion between the cytochrome c oxidase subunit II (COII) and tRNA(Lys) genes was also prevalent in both the Pima and the Maya. These data suggest that Amerindian mtDNAs derived from at least four primary maternal lineages, that new tribal-specific variants accumulated as these mtDNAs became distributed throughout the Americas, and that some genetic variation may have been lost when the progenitors of the Ticuna separated from the North and Central American populations. American Society of Human Genetic 1990-03 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40020/1/Amerindian%20mitochondrial%20DNAs%20have%20rare%20Asian%20mutations%20at%20high%20frequencies%2C%20suggesting%20they%20derived%20from%20four%20primary%20maternal%20lineages.pdf Schurr, Theodore G. and Ballinger, Scott W. and Gan, Yik Yuen and Hodge, Judith A. and Merriwether, David Andrew and Lawrence, Dale N. and Knowler, William C. and Weiss, Kenneth M. and Wallace, Douglas C. (1990) Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages. American Journal of Human Genetics, 46 (3). pp. 613-623. ISSN 0002-9297
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
language	English
description	The mitochondrial DNA (mtDNA) sequence variation of the South American Ticuna, the Central American Maya, and the North American Pima was analyzed by restriction-endonuclease digestion and oligonucleotide hybridization. The analysis revealed that Amerindian populations have high frequencies of mtDNAs containing the rare Asian RFLP HincII morph 6, a rare HaeIII site gain, and a unique AluI site gain. In addition, the Asian-specific deletion between the cytochrome c oxidase subunit II (COII) and tRNA(Lys) genes was also prevalent in both the Pima and the Maya. These data suggest that Amerindian mtDNAs derived from at least four primary maternal lineages, that new tribal-specific variants accumulated as these mtDNAs became distributed throughout the Americas, and that some genetic variation may have been lost when the progenitors of the Ticuna separated from the North and Central American populations.
format	Article
author	Schurr, Theodore G. Ballinger, Scott W. Gan, Yik Yuen Hodge, Judith A. Merriwether, David Andrew Lawrence, Dale N. Knowler, William C. Weiss, Kenneth M. Wallace, Douglas C.
spellingShingle	Schurr, Theodore G. Ballinger, Scott W. Gan, Yik Yuen Hodge, Judith A. Merriwether, David Andrew Lawrence, Dale N. Knowler, William C. Weiss, Kenneth M. Wallace, Douglas C. Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages
author_facet	Schurr, Theodore G. Ballinger, Scott W. Gan, Yik Yuen Hodge, Judith A. Merriwether, David Andrew Lawrence, Dale N. Knowler, William C. Weiss, Kenneth M. Wallace, Douglas C.
author_sort	Schurr, Theodore G.
title	Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages
title_short	Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages
title_full	Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages
title_fullStr	Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages
title_full_unstemmed	Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages
title_sort	amerindian mitochondrial dnas have rare asian mutations at high frequencies, suggesting they derived from four primary maternal lineages
publisher	American Society of Human Genetic
publishDate	1990
url	http://psasir.upm.edu.my/id/eprint/40020/1/Amerindian%20mitochondrial%20DNAs%20have%20rare%20Asian%20mutations%20at%20high%20frequencies%2C%20suggesting%20they%20derived%20from%20four%20primary%20maternal%20lineages.pdf http://psasir.upm.edu.my/id/eprint/40020/
_version_	1643832593347510272
score	13.211869

Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages

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