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Carotenoids: how effective are they to prevent age-related diseases?

Despite an increase in life expectancy that indicates positive human development, a new challenge is arising. Aging is positively associated with biological and cognitive degeneration, for instance cognitive decline, psychological impairment, and physical frailty. The elderly population is prone to...

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Main Authors: Tan, Bee Ling, Mohd Esa, Norhaizan
Format: Article
Language:English
Published: MDPI 2019
Online Access:http://psasir.upm.edu.my/id/eprint/38371/1/38371.pdf
http://psasir.upm.edu.my/id/eprint/38371/
https://www.mdpi.com/1420-3049/24/9/1801
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spelling my.upm.eprints.383712020-05-04T16:24:51Z http://psasir.upm.edu.my/id/eprint/38371/ Carotenoids: how effective are they to prevent age-related diseases? Tan, Bee Ling Mohd Esa, Norhaizan Despite an increase in life expectancy that indicates positive human development, a new challenge is arising. Aging is positively associated with biological and cognitive degeneration, for instance cognitive decline, psychological impairment, and physical frailty. The elderly population is prone to oxidative stress due to the inefficiency of their endogenous antioxidant systems. As many studies showed an inverse relationship between carotenoids and age-related diseases (ARD) by reducing oxidative stress through interrupting the propagation of free radicals, carotenoid has been foreseen as a potential intervention for age-associated pathologies. Therefore, the role of carotenoids that counteract oxidative stress and promote healthy aging is worthy of further discussion. In this review, we discussed the underlying mechanisms of carotenoids involved in the prevention of ARD. Collectively, understanding the role of carotenoids in ARD would provide insights into a potential intervention that may affect the aging process, and subsequently promote healthy longevity. MDPI 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/38371/1/38371.pdf Tan, Bee Ling and Mohd Esa, Norhaizan (2019) Carotenoids: how effective are they to prevent age-related diseases? Molecules, 24 (9). art. no. 1801. pp. 1-23. ISSN 1420-3049 https://www.mdpi.com/1420-3049/24/9/1801 10.3390/molecules24091801
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Despite an increase in life expectancy that indicates positive human development, a new challenge is arising. Aging is positively associated with biological and cognitive degeneration, for instance cognitive decline, psychological impairment, and physical frailty. The elderly population is prone to oxidative stress due to the inefficiency of their endogenous antioxidant systems. As many studies showed an inverse relationship between carotenoids and age-related diseases (ARD) by reducing oxidative stress through interrupting the propagation of free radicals, carotenoid has been foreseen as a potential intervention for age-associated pathologies. Therefore, the role of carotenoids that counteract oxidative stress and promote healthy aging is worthy of further discussion. In this review, we discussed the underlying mechanisms of carotenoids involved in the prevention of ARD. Collectively, understanding the role of carotenoids in ARD would provide insights into a potential intervention that may affect the aging process, and subsequently promote healthy longevity.
format Article
author Tan, Bee Ling
Mohd Esa, Norhaizan
spellingShingle Tan, Bee Ling
Mohd Esa, Norhaizan
Carotenoids: how effective are they to prevent age-related diseases?
author_facet Tan, Bee Ling
Mohd Esa, Norhaizan
author_sort Tan, Bee Ling
title Carotenoids: how effective are they to prevent age-related diseases?
title_short Carotenoids: how effective are they to prevent age-related diseases?
title_full Carotenoids: how effective are they to prevent age-related diseases?
title_fullStr Carotenoids: how effective are they to prevent age-related diseases?
title_full_unstemmed Carotenoids: how effective are they to prevent age-related diseases?
title_sort carotenoids: how effective are they to prevent age-related diseases?
publisher MDPI
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/38371/1/38371.pdf
http://psasir.upm.edu.my/id/eprint/38371/
https://www.mdpi.com/1420-3049/24/9/1801
_version_ 1665895979860099072
score 13.211869

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