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Exploring the prospects of engineered Newcastle disease virus in modern vaccinology

Many traditional vaccines have proven to be incapable of controlling newly emerging infectious diseases. They have also achieved limited success in the fight against a variety of human cancers. Thus, innovative vaccine strategies are highly needed to overcome the global burden of these diseases. Adv...

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Main Authors: Bello, Muhammad Bashir, Mohd Yusoff, Khatijah, Ideris, Aini, Bejo, Mohd Hair, Jibril, Abdurrahman Hassan, Peeters, Ben P. H., Omar, Abdul Rahman
Format: Article
Language:English
Published: MDPI 2020
Online Access:http://psasir.upm.edu.my/id/eprint/38363/1/38363.pdf
http://psasir.upm.edu.my/id/eprint/38363/
https://www.mdpi.com/1999-4915/12/4/451
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spelling my.upm.eprints.383632020-05-04T16:23:35Z http://psasir.upm.edu.my/id/eprint/38363/ Exploring the prospects of engineered Newcastle disease virus in modern vaccinology Bello, Muhammad Bashir Mohd Yusoff, Khatijah Ideris, Aini Bejo, Mohd Hair Jibril, Abdurrahman Hassan Peeters, Ben P. H. Omar, Abdul Rahman Many traditional vaccines have proven to be incapable of controlling newly emerging infectious diseases. They have also achieved limited success in the fight against a variety of human cancers. Thus, innovative vaccine strategies are highly needed to overcome the global burden of these diseases. Advances in molecular biology and reverse genetics have completely restructured the concept of vaccinology, leading to the emergence of state-of-the-art technologies for vaccine design, development and delivery. Among these modern vaccine technologies are the recombinant viral vectored vaccines, which are known for their incredible specificity in antigen delivery as well as the induction of robust immune responses in the vaccinated hosts. Although a number of viruses have been used as vaccine vectors, genetically engineered Newcastle disease virus (NDV) possesses some useful attributes that make it a preferable candidate for vectoring vaccine antigens. Here, we review the molecular biology of NDV and discuss the reverse genetics approaches used to engineer the virus into an efficient vaccine vector. We then discuss the prospects of the engineered virus as an efficient vehicle of vaccines against cancer and several infectious diseases of man and animals. MDPI 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/38363/1/38363.pdf Bello, Muhammad Bashir and Mohd Yusoff, Khatijah and Ideris, Aini and Bejo, Mohd Hair and Jibril, Abdurrahman Hassan and Peeters, Ben P. H. and Omar, Abdul Rahman (2020) Exploring the prospects of engineered Newcastle disease virus in modern vaccinology. Viruses, 12 (4). art. no. 451. pp. 1-23. ISSN 1999-4915 https://www.mdpi.com/1999-4915/12/4/451 10.3390/v12040451
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Many traditional vaccines have proven to be incapable of controlling newly emerging infectious diseases. They have also achieved limited success in the fight against a variety of human cancers. Thus, innovative vaccine strategies are highly needed to overcome the global burden of these diseases. Advances in molecular biology and reverse genetics have completely restructured the concept of vaccinology, leading to the emergence of state-of-the-art technologies for vaccine design, development and delivery. Among these modern vaccine technologies are the recombinant viral vectored vaccines, which are known for their incredible specificity in antigen delivery as well as the induction of robust immune responses in the vaccinated hosts. Although a number of viruses have been used as vaccine vectors, genetically engineered Newcastle disease virus (NDV) possesses some useful attributes that make it a preferable candidate for vectoring vaccine antigens. Here, we review the molecular biology of NDV and discuss the reverse genetics approaches used to engineer the virus into an efficient vaccine vector. We then discuss the prospects of the engineered virus as an efficient vehicle of vaccines against cancer and several infectious diseases of man and animals.
format Article
author Bello, Muhammad Bashir
Mohd Yusoff, Khatijah
Ideris, Aini
Bejo, Mohd Hair
Jibril, Abdurrahman Hassan
Peeters, Ben P. H.
Omar, Abdul Rahman
spellingShingle Bello, Muhammad Bashir
Mohd Yusoff, Khatijah
Ideris, Aini
Bejo, Mohd Hair
Jibril, Abdurrahman Hassan
Peeters, Ben P. H.
Omar, Abdul Rahman
Exploring the prospects of engineered Newcastle disease virus in modern vaccinology
author_facet Bello, Muhammad Bashir
Mohd Yusoff, Khatijah
Ideris, Aini
Bejo, Mohd Hair
Jibril, Abdurrahman Hassan
Peeters, Ben P. H.
Omar, Abdul Rahman
author_sort Bello, Muhammad Bashir
title Exploring the prospects of engineered Newcastle disease virus in modern vaccinology
title_short Exploring the prospects of engineered Newcastle disease virus in modern vaccinology
title_full Exploring the prospects of engineered Newcastle disease virus in modern vaccinology
title_fullStr Exploring the prospects of engineered Newcastle disease virus in modern vaccinology
title_full_unstemmed Exploring the prospects of engineered Newcastle disease virus in modern vaccinology
title_sort exploring the prospects of engineered newcastle disease virus in modern vaccinology
publisher MDPI
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/38363/1/38363.pdf
http://psasir.upm.edu.my/id/eprint/38363/
https://www.mdpi.com/1999-4915/12/4/451
_version_ 1665895979092541440
score 13.211869

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