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Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer

While curcumin has a range of therapeutic benefits, its potent anticancer activity remains an attractive avenue for anticancer research owing to the multifactorial nature of cancer itself. The structure of curcumin has thus been used as a lead to design more potent analogues, and diarylpentanoids in...

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Main Authors: Paulraj, Felicia Simone, Abas, Faridah, Lajis, Nordin, Othman, Iekhsan, Naidu, Rakesh
Format: Article
Language:English
Published: MDPI 2019
Online Access:http://psasir.upm.edu.my/id/eprint/38331/1/38331.pdf
http://psasir.upm.edu.my/id/eprint/38331/
https://www.mdpi.com/2218-273X/9/7/270
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spelling my.upm.eprints.383312020-05-04T16:18:22Z http://psasir.upm.edu.my/id/eprint/38331/ Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer Paulraj, Felicia Simone Abas, Faridah Lajis, Nordin Othman, Iekhsan Naidu, Rakesh While curcumin has a range of therapeutic benefits, its potent anticancer activity remains an attractive avenue for anticancer research owing to the multifactorial nature of cancer itself. The structure of curcumin has thus been used as a lead to design more potent analogues, and diarylpentanoids in particular have shown improved cytotoxicity over curcumin. Investigations of diarylpentanoids have demonstrated that these compounds exert anti-cancer effects through several signalling pathways that are associated with cancer. This review focuses on selected diarylpentanoids and highlights molecular targets that modulate key pathways involved in cancer such as NF-κB, MAPK/ERK, and STAT signalling. Future research will need to focus on drug interactions to explore potential synergistic actions of diarylpentanoids and further establish the use of diverse animal models. MDPI 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/38331/1/38331.pdf Paulraj, Felicia Simone and Abas, Faridah and Lajis, Nordin and Othman, Iekhsan and Naidu, Rakesh (2019) Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer. Biomolecules, 9 (7). art. no. 270. pp. 1-14. ISSN 2218-273X https://www.mdpi.com/2218-273X/9/7/270 10.3390/biom9070270
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description While curcumin has a range of therapeutic benefits, its potent anticancer activity remains an attractive avenue for anticancer research owing to the multifactorial nature of cancer itself. The structure of curcumin has thus been used as a lead to design more potent analogues, and diarylpentanoids in particular have shown improved cytotoxicity over curcumin. Investigations of diarylpentanoids have demonstrated that these compounds exert anti-cancer effects through several signalling pathways that are associated with cancer. This review focuses on selected diarylpentanoids and highlights molecular targets that modulate key pathways involved in cancer such as NF-κB, MAPK/ERK, and STAT signalling. Future research will need to focus on drug interactions to explore potential synergistic actions of diarylpentanoids and further establish the use of diverse animal models.
format Article
author Paulraj, Felicia Simone
Abas, Faridah
Lajis, Nordin
Othman, Iekhsan
Naidu, Rakesh
spellingShingle Paulraj, Felicia Simone
Abas, Faridah
Lajis, Nordin
Othman, Iekhsan
Naidu, Rakesh
Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer
author_facet Paulraj, Felicia Simone
Abas, Faridah
Lajis, Nordin
Othman, Iekhsan
Naidu, Rakesh
author_sort Paulraj, Felicia Simone
title Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer
title_short Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer
title_full Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer
title_fullStr Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer
title_full_unstemmed Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer
title_sort molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer
publisher MDPI
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/38331/1/38331.pdf
http://psasir.upm.edu.my/id/eprint/38331/
https://www.mdpi.com/2218-273X/9/7/270
_version_ 1665895976000290816
score 13.211869

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