Cover Image

Effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function

Cognitive dysfunction is linked to chronic low-grade inflammatory stress that contributes to cell-mediated immunity in creating an oxidative environment. Food is a vitally important energy source; it affects brain function and provides direct energy. Several studies have indicated that high-fat cons...

Full description

Saved in:
Bibliographic Details
Main Authors: Tan, Bee Ling, Mohd Esa, Norhaizan
Format: Article
Language:English
Published: MDPI 2019
Online Access:http://psasir.upm.edu.my/id/eprint/38225/1/38225.pdf
http://psasir.upm.edu.my/id/eprint/38225/
https://www.mdpi.com/2072-6643/11/11/2579
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.38225
record_format eprints
spelling my.upm.eprints.382252020-05-04T16:00:25Z http://psasir.upm.edu.my/id/eprint/38225/ Effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function Tan, Bee Ling Mohd Esa, Norhaizan Cognitive dysfunction is linked to chronic low-grade inflammatory stress that contributes to cell-mediated immunity in creating an oxidative environment. Food is a vitally important energy source; it affects brain function and provides direct energy. Several studies have indicated that high-fat consumption causes overproduction of circulating free fatty acids and systemic inflammation. Immune cells, free fatty acids, and circulating cytokines reach the hypothalamus and initiate local inflammation through processes such as microglial proliferation. Therefore, the role of high-fat diet (HFD) in promoting oxidative stress and neurodegeneration is worthy of further discussion. Of particular interest in this article, we highlight the associations and molecular mechanisms of HFD in the modulation of inflammation and cognitive deficits. Taken together, a better understanding of the role of oxidative stress in cognitive impairment following HFD consumption would provide a useful approach for the prevention of cognitive dysfunction. MDPI 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/38225/1/38225.pdf Tan, Bee Ling and Mohd Esa, Norhaizan (2019) Effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function. Nutrients, 11 (11). art. no. 2579. pp. 1-22. ISSN 2072-6643 https://www.mdpi.com/2072-6643/11/11/2579 10.3390/nu11112579
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Cognitive dysfunction is linked to chronic low-grade inflammatory stress that contributes to cell-mediated immunity in creating an oxidative environment. Food is a vitally important energy source; it affects brain function and provides direct energy. Several studies have indicated that high-fat consumption causes overproduction of circulating free fatty acids and systemic inflammation. Immune cells, free fatty acids, and circulating cytokines reach the hypothalamus and initiate local inflammation through processes such as microglial proliferation. Therefore, the role of high-fat diet (HFD) in promoting oxidative stress and neurodegeneration is worthy of further discussion. Of particular interest in this article, we highlight the associations and molecular mechanisms of HFD in the modulation of inflammation and cognitive deficits. Taken together, a better understanding of the role of oxidative stress in cognitive impairment following HFD consumption would provide a useful approach for the prevention of cognitive dysfunction.
format Article
author Tan, Bee Ling
Mohd Esa, Norhaizan
spellingShingle Tan, Bee Ling
Mohd Esa, Norhaizan
Effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function
author_facet Tan, Bee Ling
Mohd Esa, Norhaizan
author_sort Tan, Bee Ling
title Effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function
title_short Effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function
title_full Effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function
title_fullStr Effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function
title_full_unstemmed Effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function
title_sort effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function
publisher MDPI
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/38225/1/38225.pdf
http://psasir.upm.edu.my/id/eprint/38225/
https://www.mdpi.com/2072-6643/11/11/2579
_version_ 1665895965745217536
score 13.211869

Similar Items