Cover Image

Primary membranous glomerulonephritis: the role of serum and urine biomarkers in patient management

The detection of phospholipase A2 receptor (PLA2R) and thrombospondin domain containing 7A THSD7A among primary membranous glomerulonephritis (MGN) patients transformed the diagnosis, treatment monitoring, and prognosis. Anti-PLA2R can be detected in 70–90% of primary MGN patients while anti-THSD7A...

Full description

Saved in:
Bibliographic Details
Main Authors: Maifata, Sadiq Mu'azu, Hod, Rafidah, Zakaria, Nor Fadhlina, Abd. Ghani, Fauzah
Format: Article
Language:English
Published: MDPI 2019
Online Access:http://psasir.upm.edu.my/id/eprint/38222/1/38222.pdf
http://psasir.upm.edu.my/id/eprint/38222/
https://www.mdpi.com/2227-9059/7/4/86
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.38222
record_format eprints
spelling my.upm.eprints.382222020-05-04T16:00:08Z http://psasir.upm.edu.my/id/eprint/38222/ Primary membranous glomerulonephritis: the role of serum and urine biomarkers in patient management Maifata, Sadiq Mu'azu Hod, Rafidah Zakaria, Nor Fadhlina Abd. Ghani, Fauzah The detection of phospholipase A2 receptor (PLA2R) and thrombospondin domain containing 7A THSD7A among primary membranous glomerulonephritis (MGN) patients transformed the diagnosis, treatment monitoring, and prognosis. Anti-PLA2R can be detected in 70–90% of primary MGN patients while anti-THSD7A in 2–3% of anti-PLA2R negative primary MGN patients depending on the technique used. Serum and urine samples are less invasive and non-invasive, respectively, and thus can detect the presence of anti-PLA2R and anti-THSD7A with higher sensitivity and specificity, which is significant in patient monitoring and prognosis. It is better than exposing patients to a frequent biopsy, which is an invasive procedure. Different techniques of detection of PLA2R and THSD7A in patients’ urine and sera were reviewed to provide newer and alternative techniques. We proposed the use of biomarkers (PLA2R and THSD7A) in the diagnosis, treatment decision, and follow-up of patients with primary MGN. In addition, other prognostic renal biomarkers like retinol binding protein (RBP) and beta-2 microglobulin were reviewed to detect the progression of renal damage for early intervention. MDPI 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/38222/1/38222.pdf Maifata, Sadiq Mu'azu and Hod, Rafidah and Zakaria, Nor Fadhlina and Abd. Ghani, Fauzah (2019) Primary membranous glomerulonephritis: the role of serum and urine biomarkers in patient management. Biomedicines, 7 (4). art. no. 86. pp. 1-14. ISSN 2227-9059 https://www.mdpi.com/2227-9059/7/4/86 10.3390/biomedicines7040086
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The detection of phospholipase A2 receptor (PLA2R) and thrombospondin domain containing 7A THSD7A among primary membranous glomerulonephritis (MGN) patients transformed the diagnosis, treatment monitoring, and prognosis. Anti-PLA2R can be detected in 70–90% of primary MGN patients while anti-THSD7A in 2–3% of anti-PLA2R negative primary MGN patients depending on the technique used. Serum and urine samples are less invasive and non-invasive, respectively, and thus can detect the presence of anti-PLA2R and anti-THSD7A with higher sensitivity and specificity, which is significant in patient monitoring and prognosis. It is better than exposing patients to a frequent biopsy, which is an invasive procedure. Different techniques of detection of PLA2R and THSD7A in patients’ urine and sera were reviewed to provide newer and alternative techniques. We proposed the use of biomarkers (PLA2R and THSD7A) in the diagnosis, treatment decision, and follow-up of patients with primary MGN. In addition, other prognostic renal biomarkers like retinol binding protein (RBP) and beta-2 microglobulin were reviewed to detect the progression of renal damage for early intervention.
format Article
author Maifata, Sadiq Mu'azu
Hod, Rafidah
Zakaria, Nor Fadhlina
Abd. Ghani, Fauzah
spellingShingle Maifata, Sadiq Mu'azu
Hod, Rafidah
Zakaria, Nor Fadhlina
Abd. Ghani, Fauzah
Primary membranous glomerulonephritis: the role of serum and urine biomarkers in patient management
author_facet Maifata, Sadiq Mu'azu
Hod, Rafidah
Zakaria, Nor Fadhlina
Abd. Ghani, Fauzah
author_sort Maifata, Sadiq Mu'azu
title Primary membranous glomerulonephritis: the role of serum and urine biomarkers in patient management
title_short Primary membranous glomerulonephritis: the role of serum and urine biomarkers in patient management
title_full Primary membranous glomerulonephritis: the role of serum and urine biomarkers in patient management
title_fullStr Primary membranous glomerulonephritis: the role of serum and urine biomarkers in patient management
title_full_unstemmed Primary membranous glomerulonephritis: the role of serum and urine biomarkers in patient management
title_sort primary membranous glomerulonephritis: the role of serum and urine biomarkers in patient management
publisher MDPI
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/38222/1/38222.pdf
http://psasir.upm.edu.my/id/eprint/38222/
https://www.mdpi.com/2227-9059/7/4/86
_version_ 1665895965457907712
score 13.211869

Similar Items