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Mechanistic understanding of curcumin's therapeutic effects in lung cancer

Lung cancer is among the most common cancers with a high mortality rate worldwide. Despite the significant advances in diagnostic and therapeutic approaches, lung cancer prognoses and survival rates remain poor due to late diagnosis, drug resistance, and adverse effects. Therefore, new intervention...

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Main Authors: Wan Mohd Tajuddin, Wan Nur Baitty, Lajis, Nordin, Abas, Faridah, Othman, Iekhsan, Naidu, Rakesh
Format: Article
Language:English
Published: MDPI 2019
Online Access:http://psasir.upm.edu.my/id/eprint/38203/1/38203.pdf
http://psasir.upm.edu.my/id/eprint/38203/
https://www.mdpi.com/2072-6643/11/12/2989
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spelling my.upm.eprints.382032020-05-04T15:53:07Z http://psasir.upm.edu.my/id/eprint/38203/ Mechanistic understanding of curcumin's therapeutic effects in lung cancer Wan Mohd Tajuddin, Wan Nur Baitty Lajis, Nordin Abas, Faridah Othman, Iekhsan Naidu, Rakesh Lung cancer is among the most common cancers with a high mortality rate worldwide. Despite the significant advances in diagnostic and therapeutic approaches, lung cancer prognoses and survival rates remain poor due to late diagnosis, drug resistance, and adverse effects. Therefore, new intervention therapies, such as the use of natural compounds with decreased toxicities, have been considered in lung cancer therapy. Curcumin, a natural occurring polyphenol derived from turmeric (Curcuma longa) has been studied extensively in recent years for its therapeutic effects. It has been shown that curcumin demonstrates anti-cancer effects in lung cancer through various mechanisms, including inhibition of cell proliferation, invasion, and metastasis, induction of apoptosis, epigenetic alterations, and regulation of microRNA expression. Several in vitro and in vivo studies have shown that these mechanisms are modulated by multiple molecular targets such as STAT3, EGFR, FOXO3a, TGF-β, eIF2α, COX-2, Bcl-2, PI3KAkt/mTOR, ROS, Fas/FasL, Cdc42, E-cadherin, MMPs, and adiponectin. In addition, limitations, strategies to overcome curcumin bioavailability, and potential side effects as well as clinical trials were also reviewed. MDPI 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/38203/1/38203.pdf Wan Mohd Tajuddin, Wan Nur Baitty and Lajis, Nordin and Abas, Faridah and Othman, Iekhsan and Naidu, Rakesh (2019) Mechanistic understanding of curcumin's therapeutic effects in lung cancer. Nutrients, 11 (12). art. no. 2989. pp. 1-29. ISSN 2072-6643 https://www.mdpi.com/2072-6643/11/12/2989 10.3390/nu11122989
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Lung cancer is among the most common cancers with a high mortality rate worldwide. Despite the significant advances in diagnostic and therapeutic approaches, lung cancer prognoses and survival rates remain poor due to late diagnosis, drug resistance, and adverse effects. Therefore, new intervention therapies, such as the use of natural compounds with decreased toxicities, have been considered in lung cancer therapy. Curcumin, a natural occurring polyphenol derived from turmeric (Curcuma longa) has been studied extensively in recent years for its therapeutic effects. It has been shown that curcumin demonstrates anti-cancer effects in lung cancer through various mechanisms, including inhibition of cell proliferation, invasion, and metastasis, induction of apoptosis, epigenetic alterations, and regulation of microRNA expression. Several in vitro and in vivo studies have shown that these mechanisms are modulated by multiple molecular targets such as STAT3, EGFR, FOXO3a, TGF-β, eIF2α, COX-2, Bcl-2, PI3KAkt/mTOR, ROS, Fas/FasL, Cdc42, E-cadherin, MMPs, and adiponectin. In addition, limitations, strategies to overcome curcumin bioavailability, and potential side effects as well as clinical trials were also reviewed.
format Article
author Wan Mohd Tajuddin, Wan Nur Baitty
Lajis, Nordin
Abas, Faridah
Othman, Iekhsan
Naidu, Rakesh
spellingShingle Wan Mohd Tajuddin, Wan Nur Baitty
Lajis, Nordin
Abas, Faridah
Othman, Iekhsan
Naidu, Rakesh
Mechanistic understanding of curcumin's therapeutic effects in lung cancer
author_facet Wan Mohd Tajuddin, Wan Nur Baitty
Lajis, Nordin
Abas, Faridah
Othman, Iekhsan
Naidu, Rakesh
author_sort Wan Mohd Tajuddin, Wan Nur Baitty
title Mechanistic understanding of curcumin's therapeutic effects in lung cancer
title_short Mechanistic understanding of curcumin's therapeutic effects in lung cancer
title_full Mechanistic understanding of curcumin's therapeutic effects in lung cancer
title_fullStr Mechanistic understanding of curcumin's therapeutic effects in lung cancer
title_full_unstemmed Mechanistic understanding of curcumin's therapeutic effects in lung cancer
title_sort mechanistic understanding of curcumin's therapeutic effects in lung cancer
publisher MDPI
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/38203/1/38203.pdf
http://psasir.upm.edu.my/id/eprint/38203/
https://www.mdpi.com/2072-6643/11/12/2989
_version_ 1665895963600879616
score 13.211869

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