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Endothelial dysfunction in obesity-induced inflammation: molecular mechanisms and clinical implications

Obesity is characterized by the excessive deposition of fat that may interfere with the normal metabolic process of the body. It is a chronic condition associated with various metabolic syndromes, whose prevalence is grossly increasing, and affects both children and adults. Accumulation of excessive...

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Main Authors: Kwaifa, Ibrahim Kalle, Bahari, Hasnah, Yong, Yoke Keong, Md Noor, Sabariah
Format: Article
Language:English
Published: MDPI 2020
Online Access:http://psasir.upm.edu.my/id/eprint/38151/1/38151.pdf
http://psasir.upm.edu.my/id/eprint/38151/
https://www.mdpi.com/2218-273X/10/2/291
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spelling my.upm.eprints.381512020-05-03T22:59:27Z http://psasir.upm.edu.my/id/eprint/38151/ Endothelial dysfunction in obesity-induced inflammation: molecular mechanisms and clinical implications Kwaifa, Ibrahim Kalle Bahari, Hasnah Yong, Yoke Keong Md Noor, Sabariah Obesity is characterized by the excessive deposition of fat that may interfere with the normal metabolic process of the body. It is a chronic condition associated with various metabolic syndromes, whose prevalence is grossly increasing, and affects both children and adults. Accumulation of excessive macronutrients on the adipose tissues promotes the secretion and release of inflammatory mediators, including interleukin-6 (IL-6), interleukin 1β, tumor necrotic factor-α (TNF-α), leptin, and stimulation of monocyte chemoattractant protein-1 (MCP-1), which subsequently reduce the production of adiponectin thereby initiating a proinflammatory state. During obesity, adipose tissue synthesizes and releases a large number of hormones and cytokines that alter the metabolic processes, with a profound influence on endothelial dysfunction, a situation associated with the formation of atherosclerotic plaque. Endothelial cells respond to inflammation and stimulation of MCP-1, which is described as the activation of adhesion molecules leading to proliferation and transmigration of leukocytes, which facilitates their increase in atherogenic and thromboembolic potentials. Endothelial dysfunction forms the cornerstone of this discussion, as it has been considered as the initiator in the progression of cardiovascular diseases in obesity. Overexpression of proinflammatory cytokines with subsequent reduction of anti-inflammatory markers in obesity, is considered to be the link between obesity-induced inflammation and endothelial dysfunction. Inhibition of inflammatory mechanisms and management and control of obesity can assist in reducing the risks associated with cardiovascular complications. MDPI 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/38151/1/38151.pdf Kwaifa, Ibrahim Kalle and Bahari, Hasnah and Yong, Yoke Keong and Md Noor, Sabariah (2020) Endothelial dysfunction in obesity-induced inflammation: molecular mechanisms and clinical implications. Biomolecules, 10 (2). art. no. 291. pp. 1-21. ISSN 2218-273X https://www.mdpi.com/2218-273X/10/2/291 10.3390/biom10020291
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Obesity is characterized by the excessive deposition of fat that may interfere with the normal metabolic process of the body. It is a chronic condition associated with various metabolic syndromes, whose prevalence is grossly increasing, and affects both children and adults. Accumulation of excessive macronutrients on the adipose tissues promotes the secretion and release of inflammatory mediators, including interleukin-6 (IL-6), interleukin 1β, tumor necrotic factor-α (TNF-α), leptin, and stimulation of monocyte chemoattractant protein-1 (MCP-1), which subsequently reduce the production of adiponectin thereby initiating a proinflammatory state. During obesity, adipose tissue synthesizes and releases a large number of hormones and cytokines that alter the metabolic processes, with a profound influence on endothelial dysfunction, a situation associated with the formation of atherosclerotic plaque. Endothelial cells respond to inflammation and stimulation of MCP-1, which is described as the activation of adhesion molecules leading to proliferation and transmigration of leukocytes, which facilitates their increase in atherogenic and thromboembolic potentials. Endothelial dysfunction forms the cornerstone of this discussion, as it has been considered as the initiator in the progression of cardiovascular diseases in obesity. Overexpression of proinflammatory cytokines with subsequent reduction of anti-inflammatory markers in obesity, is considered to be the link between obesity-induced inflammation and endothelial dysfunction. Inhibition of inflammatory mechanisms and management and control of obesity can assist in reducing the risks associated with cardiovascular complications.
format Article
author Kwaifa, Ibrahim Kalle
Bahari, Hasnah
Yong, Yoke Keong
Md Noor, Sabariah
spellingShingle Kwaifa, Ibrahim Kalle
Bahari, Hasnah
Yong, Yoke Keong
Md Noor, Sabariah
Endothelial dysfunction in obesity-induced inflammation: molecular mechanisms and clinical implications
author_facet Kwaifa, Ibrahim Kalle
Bahari, Hasnah
Yong, Yoke Keong
Md Noor, Sabariah
author_sort Kwaifa, Ibrahim Kalle
title Endothelial dysfunction in obesity-induced inflammation: molecular mechanisms and clinical implications
title_short Endothelial dysfunction in obesity-induced inflammation: molecular mechanisms and clinical implications
title_full Endothelial dysfunction in obesity-induced inflammation: molecular mechanisms and clinical implications
title_fullStr Endothelial dysfunction in obesity-induced inflammation: molecular mechanisms and clinical implications
title_full_unstemmed Endothelial dysfunction in obesity-induced inflammation: molecular mechanisms and clinical implications
title_sort endothelial dysfunction in obesity-induced inflammation: molecular mechanisms and clinical implications
publisher MDPI
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/38151/1/38151.pdf
http://psasir.upm.edu.my/id/eprint/38151/
https://www.mdpi.com/2218-273X/10/2/291
_version_ 1665895958518431744
score 13.211869

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