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Role of serum and urine biomarkers (PLA2R and THSD7A) in diagnosis, monitoring and prognostication of primary membranous glomerulonephritis

Differentiating primary and secondary membranous glomerulonephritis (MGN) using biomarkers for MGN is essential in patients’ diagnosis, treatment and follow-up. Although biopsy has been the primary tool in making the diagnosis, not all patients can withstand it due to its invasive nature, and it can...

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Main Authors: Maifata, Sadiq Mu'azu, Hod, Rafidah, Zakaria, Nor Fadhlina, Abd. Ghani, Fauzah
Format: Article
Language:English
Published: MDPI 2020
Online Access:http://psasir.upm.edu.my/id/eprint/38143/1/38143.pdf
http://psasir.upm.edu.my/id/eprint/38143/
https://www.mdpi.com/2218-273X/10/2/319
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spelling my.upm.eprints.381432020-05-03T22:57:41Z http://psasir.upm.edu.my/id/eprint/38143/ Role of serum and urine biomarkers (PLA2R and THSD7A) in diagnosis, monitoring and prognostication of primary membranous glomerulonephritis Maifata, Sadiq Mu'azu Hod, Rafidah Zakaria, Nor Fadhlina Abd. Ghani, Fauzah Differentiating primary and secondary membranous glomerulonephritis (MGN) using biomarkers for MGN is essential in patients’ diagnosis, treatment and follow-up. Although biopsy has been the primary tool in making the diagnosis, not all patients can withstand it due to its invasive nature, and it cannot be used to monitor treatment. Hence, there is the need for less invasive or even non-invasive biomarkers for effective diagnosis, treatment monitoring and prognostication. This study aimed at providing an alternative way of differentiating primary and secondary MGN using enzyme-linked immunosorbent assay (ELISA) technique for serum and urine biomarkers (M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A)) for prompt diagnosis, treatment and prognosis. A total of 125 subjects, including 81 primary and 44 secondary MGN subjects, were diagnosed from January 2012 to October 2019 at Hospital Serdang and Hospital Kuala Lumpur from which 69 subjects consisting of 47 primary and 22 secondary MGN subjects participated in the study. Of these, 13 primary MGN subjects were positive for both serum and urine anti-PLA2R antibodies (Ab) whereas only one secondary MGN subject associated with hepatitis B virus was positive for both serum and urine anti-PLA2R Ab. At the same time, anti-THSD7A Ab was found positive in four primary MGN subjects and two secondary MGN subjects with malignancy. MDPI 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/38143/1/38143.pdf Maifata, Sadiq Mu'azu and Hod, Rafidah and Zakaria, Nor Fadhlina and Abd. Ghani, Fauzah (2020) Role of serum and urine biomarkers (PLA2R and THSD7A) in diagnosis, monitoring and prognostication of primary membranous glomerulonephritis. Biomolecules, 10 (2). art. no. 319. pp. 1-14. ISSN 2218-273X https://www.mdpi.com/2218-273X/10/2/319 10.3390/biom10020319
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Differentiating primary and secondary membranous glomerulonephritis (MGN) using biomarkers for MGN is essential in patients’ diagnosis, treatment and follow-up. Although biopsy has been the primary tool in making the diagnosis, not all patients can withstand it due to its invasive nature, and it cannot be used to monitor treatment. Hence, there is the need for less invasive or even non-invasive biomarkers for effective diagnosis, treatment monitoring and prognostication. This study aimed at providing an alternative way of differentiating primary and secondary MGN using enzyme-linked immunosorbent assay (ELISA) technique for serum and urine biomarkers (M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A)) for prompt diagnosis, treatment and prognosis. A total of 125 subjects, including 81 primary and 44 secondary MGN subjects, were diagnosed from January 2012 to October 2019 at Hospital Serdang and Hospital Kuala Lumpur from which 69 subjects consisting of 47 primary and 22 secondary MGN subjects participated in the study. Of these, 13 primary MGN subjects were positive for both serum and urine anti-PLA2R antibodies (Ab) whereas only one secondary MGN subject associated with hepatitis B virus was positive for both serum and urine anti-PLA2R Ab. At the same time, anti-THSD7A Ab was found positive in four primary MGN subjects and two secondary MGN subjects with malignancy.
format Article
author Maifata, Sadiq Mu'azu
Hod, Rafidah
Zakaria, Nor Fadhlina
Abd. Ghani, Fauzah
spellingShingle Maifata, Sadiq Mu'azu
Hod, Rafidah
Zakaria, Nor Fadhlina
Abd. Ghani, Fauzah
Role of serum and urine biomarkers (PLA2R and THSD7A) in diagnosis, monitoring and prognostication of primary membranous glomerulonephritis
author_facet Maifata, Sadiq Mu'azu
Hod, Rafidah
Zakaria, Nor Fadhlina
Abd. Ghani, Fauzah
author_sort Maifata, Sadiq Mu'azu
title Role of serum and urine biomarkers (PLA2R and THSD7A) in diagnosis, monitoring and prognostication of primary membranous glomerulonephritis
title_short Role of serum and urine biomarkers (PLA2R and THSD7A) in diagnosis, monitoring and prognostication of primary membranous glomerulonephritis
title_full Role of serum and urine biomarkers (PLA2R and THSD7A) in diagnosis, monitoring and prognostication of primary membranous glomerulonephritis
title_fullStr Role of serum and urine biomarkers (PLA2R and THSD7A) in diagnosis, monitoring and prognostication of primary membranous glomerulonephritis
title_full_unstemmed Role of serum and urine biomarkers (PLA2R and THSD7A) in diagnosis, monitoring and prognostication of primary membranous glomerulonephritis
title_sort role of serum and urine biomarkers (pla2r and thsd7a) in diagnosis, monitoring and prognostication of primary membranous glomerulonephritis
publisher MDPI
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/38143/1/38143.pdf
http://psasir.upm.edu.my/id/eprint/38143/
https://www.mdpi.com/2218-273X/10/2/319
_version_ 1665895957743534080
score 13.211869

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