Cover Image

Effect of pomegranate on metabolic indexes and inflammatory biomarkers in STZ-NA induced diabetic rats

Type 2 Diabetes is associated not only with hyperinsulinaemia and hyperglycemia but also with other disorders such as atherosclerosis, hypertension, inflammatory disorders and abnormal lipid profiles in dyslipidemia. Fruit extracts have been used universally in treatment of chronic diseases, because...

Full description

Saved in:
Bibliographic Details
Main Authors: Rouhi, Seyedeh Zeinab Taheri, Rahmat, Asmah, Othman, Fauziah
Format: Conference or Workshop Item
Language:English
Published: Department of Biology, Faculty of Science, Universiti Putra Malaysia 2014
Online Access:http://psasir.upm.edu.my/id/eprint/38059/1/BIO%202014-80.pdf
http://psasir.upm.edu.my/id/eprint/38059/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.38059
record_format eprints
spelling my.upm.eprints.380592020-04-14T14:19:00Z http://psasir.upm.edu.my/id/eprint/38059/ Effect of pomegranate on metabolic indexes and inflammatory biomarkers in STZ-NA induced diabetic rats Rouhi, Seyedeh Zeinab Taheri Rahmat, Asmah Othman, Fauziah Type 2 Diabetes is associated not only with hyperinsulinaemia and hyperglycemia but also with other disorders such as atherosclerosis, hypertension, inflammatory disorders and abnormal lipid profiles in dyslipidemia. Fruit extracts have been used universally in treatment of chronic diseases, because they are natural, safe, and readily accessible. Pomegranate (Punica granatum Linn) has been used, as pomegranate fractions have therapeutic potential stated by multitudinous scientists using various in vitro assay systems which is due to the presence of unique bioactive compounds and polyphenolic constituents. This study was performed to evaluate the pomegranate juice and seed consumption and their potential effect on treatment of diabetes and its associated complications such as abnormalities in plasma glucose, insulin, inflammatory factors, lipid profile level and pancreatic tissue in STZ-NA induced diabetic rats. Forty adult healthy male Sprague Dawley rats were dedicated in 5 groups of 8 rats each. Diabetes mellitus was induced in 4 groups by administration of streptozotocin-nicotinamide. Diabetic animals were further treated differently for 21 days, by using oral gavage by force-feed with needle. Rats in all groups were sacrificed on day 22. The results of the study suggests that the antioxidant flavonoids and Polyphenolic active constituents present in pomegranate are possibly responsible for hypolipidemic and anti-inflammatory effect in diabetic rats which can help the cure and management of diabetes. Although the biochemical mechanisms underlying Pomegranate seed and juice activities are not yet clear, our results demonstrated that Punica granatum has a suppressor effect versus lipid abnormalities and overexpression of inflammatory cytokines which are side effects of diabetes. Department of Biology, Faculty of Science, Universiti Putra Malaysia 2014 Conference or Workshop Item PeerReviewed text en http://psasir.upm.edu.my/id/eprint/38059/1/BIO%202014-80.pdf Rouhi, Seyedeh Zeinab Taheri and Rahmat, Asmah and Othman, Fauziah (2014) Effect of pomegranate on metabolic indexes and inflammatory biomarkers in STZ-NA induced diabetic rats. In: Malaysia International Biological Symposium 2014, 28-29 Oct. 2014, Putrajaya, Malaysia. (p. 309).
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Type 2 Diabetes is associated not only with hyperinsulinaemia and hyperglycemia but also with other disorders such as atherosclerosis, hypertension, inflammatory disorders and abnormal lipid profiles in dyslipidemia. Fruit extracts have been used universally in treatment of chronic diseases, because they are natural, safe, and readily accessible. Pomegranate (Punica granatum Linn) has been used, as pomegranate fractions have therapeutic potential stated by multitudinous scientists using various in vitro assay systems which is due to the presence of unique bioactive compounds and polyphenolic constituents. This study was performed to evaluate the pomegranate juice and seed consumption and their potential effect on treatment of diabetes and its associated complications such as abnormalities in plasma glucose, insulin, inflammatory factors, lipid profile level and pancreatic tissue in STZ-NA induced diabetic rats. Forty adult healthy male Sprague Dawley rats were dedicated in 5 groups of 8 rats each. Diabetes mellitus was induced in 4 groups by administration of streptozotocin-nicotinamide. Diabetic animals were further treated differently for 21 days, by using oral gavage by force-feed with needle. Rats in all groups were sacrificed on day 22. The results of the study suggests that the antioxidant flavonoids and Polyphenolic active constituents present in pomegranate are possibly responsible for hypolipidemic and anti-inflammatory effect in diabetic rats which can help the cure and management of diabetes. Although the biochemical mechanisms underlying Pomegranate seed and juice activities are not yet clear, our results demonstrated that Punica granatum has a suppressor effect versus lipid abnormalities and overexpression of inflammatory cytokines which are side effects of diabetes.
format Conference or Workshop Item
author Rouhi, Seyedeh Zeinab Taheri
Rahmat, Asmah
Othman, Fauziah
spellingShingle Rouhi, Seyedeh Zeinab Taheri
Rahmat, Asmah
Othman, Fauziah
Effect of pomegranate on metabolic indexes and inflammatory biomarkers in STZ-NA induced diabetic rats
author_facet Rouhi, Seyedeh Zeinab Taheri
Rahmat, Asmah
Othman, Fauziah
author_sort Rouhi, Seyedeh Zeinab Taheri
title Effect of pomegranate on metabolic indexes and inflammatory biomarkers in STZ-NA induced diabetic rats
title_short Effect of pomegranate on metabolic indexes and inflammatory biomarkers in STZ-NA induced diabetic rats
title_full Effect of pomegranate on metabolic indexes and inflammatory biomarkers in STZ-NA induced diabetic rats
title_fullStr Effect of pomegranate on metabolic indexes and inflammatory biomarkers in STZ-NA induced diabetic rats
title_full_unstemmed Effect of pomegranate on metabolic indexes and inflammatory biomarkers in STZ-NA induced diabetic rats
title_sort effect of pomegranate on metabolic indexes and inflammatory biomarkers in stz-na induced diabetic rats
publisher Department of Biology, Faculty of Science, Universiti Putra Malaysia
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/38059/1/BIO%202014-80.pdf
http://psasir.upm.edu.my/id/eprint/38059/
_version_ 1665895949563592704
score 13.211869

Similar Items