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Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats

Type 2 diabetes is a chronic disease with growing public health concern globally. Finding remedies to assist this health issue requires recruiting appropriate animal model for experimental studies. This study was designated to evaluate metabolic and immunologic changes in streptozotocin-nicotinamide...

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Main Authors: Mojani, Mansooreh Sadat, Sarmadi, Vahid Hosseinpour, Vellasamy, Shalini, Sandrasaigaran, Pratheep, Rahmat, Asmah, Loh, Su Peng, Ramasamy, Rajesh
Format: Article
Language:English
Published: Elsevier 2014
Online Access:http://psasir.upm.edu.my/id/eprint/37534/1/Evaluation%20of%20metabolic%20and%20immunological%20changes%20in%20streptozotocin.pdf
http://psasir.upm.edu.my/id/eprint/37534/
http://www.sciencedirect.com/science/article/pii/S0008874914000690
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spelling my.upm.eprints.375342015-10-06T03:44:07Z http://psasir.upm.edu.my/id/eprint/37534/ Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats Mojani, Mansooreh Sadat Sarmadi, Vahid Hosseinpour Vellasamy, Shalini Sandrasaigaran, Pratheep Rahmat, Asmah Loh, Su Peng Ramasamy, Rajesh Type 2 diabetes is a chronic disease with growing public health concern globally. Finding remedies to assist this health issue requires recruiting appropriate animal model for experimental studies. This study was designated to evaluate metabolic and immunologic changes in streptozotocin-nicotinamide induced diabetic rats as a model of type 2 diabetes. Male rats were induced diabetes using nicotinamide (110 mg/kg) and streptozotocin (65 mg/kg). Following 42 days, biochemical and immunological tests showed that diabetic rats had higher levels of blood glucose, WBC, certain abnormalities in lipid profile and insufficient mitogenic responses of lymphocytes (p < 0.05). However, the status of the total antioxidant, inflammatory biomarkers and other parameters of full blood count (except HCT) were not significantly altered. Phenotyping assay indicated insignificant lymphocyte subtype imbalances excluding a significant rise in the level of CD4+CD25+ marker (p < 0.05). This model of diabetic animals may represent some but not all symptoms of human type 2 diabetes. Elsevier 2014-05 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/37534/1/Evaluation%20of%20metabolic%20and%20immunological%20changes%20in%20streptozotocin.pdf Mojani, Mansooreh Sadat and Sarmadi, Vahid Hosseinpour and Vellasamy, Shalini and Sandrasaigaran, Pratheep and Rahmat, Asmah and Loh, Su Peng and Ramasamy, Rajesh (2014) Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats. Cellular Immunology, 289 (1-2). pp. 145-149. ISSN 0008-8749; ESSN: 1090-2163 http://www.sciencedirect.com/science/article/pii/S0008874914000690 10.1016/j.cellimm.2014.04.004
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Type 2 diabetes is a chronic disease with growing public health concern globally. Finding remedies to assist this health issue requires recruiting appropriate animal model for experimental studies. This study was designated to evaluate metabolic and immunologic changes in streptozotocin-nicotinamide induced diabetic rats as a model of type 2 diabetes. Male rats were induced diabetes using nicotinamide (110 mg/kg) and streptozotocin (65 mg/kg). Following 42 days, biochemical and immunological tests showed that diabetic rats had higher levels of blood glucose, WBC, certain abnormalities in lipid profile and insufficient mitogenic responses of lymphocytes (p < 0.05). However, the status of the total antioxidant, inflammatory biomarkers and other parameters of full blood count (except HCT) were not significantly altered. Phenotyping assay indicated insignificant lymphocyte subtype imbalances excluding a significant rise in the level of CD4+CD25+ marker (p < 0.05). This model of diabetic animals may represent some but not all symptoms of human type 2 diabetes.
format Article
author Mojani, Mansooreh Sadat
Sarmadi, Vahid Hosseinpour
Vellasamy, Shalini
Sandrasaigaran, Pratheep
Rahmat, Asmah
Loh, Su Peng
Ramasamy, Rajesh
spellingShingle Mojani, Mansooreh Sadat
Sarmadi, Vahid Hosseinpour
Vellasamy, Shalini
Sandrasaigaran, Pratheep
Rahmat, Asmah
Loh, Su Peng
Ramasamy, Rajesh
Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats
author_facet Mojani, Mansooreh Sadat
Sarmadi, Vahid Hosseinpour
Vellasamy, Shalini
Sandrasaigaran, Pratheep
Rahmat, Asmah
Loh, Su Peng
Ramasamy, Rajesh
author_sort Mojani, Mansooreh Sadat
title Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats
title_short Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats
title_full Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats
title_fullStr Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats
title_full_unstemmed Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats
title_sort evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats
publisher Elsevier
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/37534/1/Evaluation%20of%20metabolic%20and%20immunological%20changes%20in%20streptozotocin.pdf
http://psasir.upm.edu.my/id/eprint/37534/
http://www.sciencedirect.com/science/article/pii/S0008874914000690
_version_ 1643832007503904768
score 13.211869

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