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Enhanced refractive index sensitivity for anomalous reflection of gold to improve performance of bio-molecular detection

Biomolecular detection techniques based on the anomalous reflection (AR) of gold may allow the development of new label-free methods for the study of biomolecular interactions. Such methods measure reflectivity at a normal incidence angle and thus are well suited to practical applications in biochip...

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Main Authors: Amir Hamzah, Amir Syahir, Kajikawa, Kotaro, Mihara, Hisakazu
Format: Article
Published: Elsevier 2014
Online Access:http://psasir.upm.edu.my/id/eprint/37461/
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spelling my.upm.eprints.374612015-05-30T09:14:57Z http://psasir.upm.edu.my/id/eprint/37461/ Enhanced refractive index sensitivity for anomalous reflection of gold to improve performance of bio-molecular detection Amir Hamzah, Amir Syahir Kajikawa, Kotaro Mihara, Hisakazu Biomolecular detection techniques based on the anomalous reflection (AR) of gold may allow the development of new label-free methods for the study of biomolecular interactions. Such methods measure reflectivity at a normal incidence angle and thus are well suited to practical applications in biochip format. Our calculations predicted that the use of an AR substrate with an optimized dielectric constant would improve the sensitivity of this technique compared to that obtained with standard gold substrates. We subsequently fabricated Au–Ag alloy substrates and their corresponding oxide composites (Au–Ag2O) to experimentally confirm the predicted higher sensitivity. The dielectric constants of these new substrates were found to result in the enhanced levels of sensitivity predicted by calculations. Elsevier 2014-01 Article PeerReviewed Amir Hamzah, Amir Syahir and Kajikawa, Kotaro and Mihara, Hisakazu (2014) Enhanced refractive index sensitivity for anomalous reflection of gold to improve performance of bio-molecular detection. Sensors and Actuators B: Chemical, 190. pp. 357-362. ISSN 0925-4005 10.1016/j.snb.2013.08.082
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Biomolecular detection techniques based on the anomalous reflection (AR) of gold may allow the development of new label-free methods for the study of biomolecular interactions. Such methods measure reflectivity at a normal incidence angle and thus are well suited to practical applications in biochip format. Our calculations predicted that the use of an AR substrate with an optimized dielectric constant would improve the sensitivity of this technique compared to that obtained with standard gold substrates. We subsequently fabricated Au–Ag alloy substrates and their corresponding oxide composites (Au–Ag2O) to experimentally confirm the predicted higher sensitivity. The dielectric constants of these new substrates were found to result in the enhanced levels of sensitivity predicted by calculations.
format Article
author Amir Hamzah, Amir Syahir
Kajikawa, Kotaro
Mihara, Hisakazu
spellingShingle Amir Hamzah, Amir Syahir
Kajikawa, Kotaro
Mihara, Hisakazu
Enhanced refractive index sensitivity for anomalous reflection of gold to improve performance of bio-molecular detection
author_facet Amir Hamzah, Amir Syahir
Kajikawa, Kotaro
Mihara, Hisakazu
author_sort Amir Hamzah, Amir Syahir
title Enhanced refractive index sensitivity for anomalous reflection of gold to improve performance of bio-molecular detection
title_short Enhanced refractive index sensitivity for anomalous reflection of gold to improve performance of bio-molecular detection
title_full Enhanced refractive index sensitivity for anomalous reflection of gold to improve performance of bio-molecular detection
title_fullStr Enhanced refractive index sensitivity for anomalous reflection of gold to improve performance of bio-molecular detection
title_full_unstemmed Enhanced refractive index sensitivity for anomalous reflection of gold to improve performance of bio-molecular detection
title_sort enhanced refractive index sensitivity for anomalous reflection of gold to improve performance of bio-molecular detection
publisher Elsevier
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/37461/
_version_ 1643831989701181440
score 13.211869

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