Cover Image

Understanding glioblastoma biomarkers: knocking a mountain with a hammer

Gliomas are the most frequent and deadly form of human primary brain tumors. Among them, the most common and aggressive type is the high-grade glioblastoma multiforme (GBM), which rapidly grows and renders patients a very poor prognosis. Meanwhile, cancer stem cells (CSCs) have been determined in gl...

Full description

Saved in:
Bibliographic Details
Main Authors: Mesrati, Malak Hassn, Behrooz, Amir Barzegar, Abuhamad, Asmaa Y., Amir Hamzah, Amir Syahir
Format: Article
Language:English
Published: MDPI 2020
Online Access:http://psasir.upm.edu.my/id/eprint/36976/1/36976.pdf
http://psasir.upm.edu.my/id/eprint/36976/
https://www.mdpi.com/2073-4409/9/5/1236
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.36976
record_format eprints
spelling my.upm.eprints.369762020-06-16T06:39:32Z http://psasir.upm.edu.my/id/eprint/36976/ Understanding glioblastoma biomarkers: knocking a mountain with a hammer Mesrati, Malak Hassn Behrooz, Amir Barzegar Abuhamad, Asmaa Y. Amir Hamzah, Amir Syahir Gliomas are the most frequent and deadly form of human primary brain tumors. Among them, the most common and aggressive type is the high-grade glioblastoma multiforme (GBM), which rapidly grows and renders patients a very poor prognosis. Meanwhile, cancer stem cells (CSCs) have been determined in gliomas and play vital roles in driving tumor growth due to their competency in self-renewal and proliferation. Studies of gliomas have recognized CSCs via specific markers. This review comprehensively examines the current knowledge of the most significant CSCs markers in gliomas in general and in glioblastoma in particular and specifically focuses on their outlook and importance in gliomas CSCs research. We suggest that CSCs should be the superior therapeutic approach by directly targeting the markers. In addition, we highlight the association of these markers with each other in relation to their cascading pathways, and interactions with functional miRNAs, providing the role of the networks axes in glioblastoma signaling pathways. MDPI 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/36976/1/36976.pdf Mesrati, Malak Hassn and Behrooz, Amir Barzegar and Abuhamad, Asmaa Y. and Amir Hamzah, Amir Syahir (2020) Understanding glioblastoma biomarkers: knocking a mountain with a hammer. Cells, 9 (5). art. no. 1236. pp. 1-18. ISSN 2073-4409 https://www.mdpi.com/2073-4409/9/5/1236 10.3390/cells9051236
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Gliomas are the most frequent and deadly form of human primary brain tumors. Among them, the most common and aggressive type is the high-grade glioblastoma multiforme (GBM), which rapidly grows and renders patients a very poor prognosis. Meanwhile, cancer stem cells (CSCs) have been determined in gliomas and play vital roles in driving tumor growth due to their competency in self-renewal and proliferation. Studies of gliomas have recognized CSCs via specific markers. This review comprehensively examines the current knowledge of the most significant CSCs markers in gliomas in general and in glioblastoma in particular and specifically focuses on their outlook and importance in gliomas CSCs research. We suggest that CSCs should be the superior therapeutic approach by directly targeting the markers. In addition, we highlight the association of these markers with each other in relation to their cascading pathways, and interactions with functional miRNAs, providing the role of the networks axes in glioblastoma signaling pathways.
format Article
author Mesrati, Malak Hassn
Behrooz, Amir Barzegar
Abuhamad, Asmaa Y.
Amir Hamzah, Amir Syahir
spellingShingle Mesrati, Malak Hassn
Behrooz, Amir Barzegar
Abuhamad, Asmaa Y.
Amir Hamzah, Amir Syahir
Understanding glioblastoma biomarkers: knocking a mountain with a hammer
author_facet Mesrati, Malak Hassn
Behrooz, Amir Barzegar
Abuhamad, Asmaa Y.
Amir Hamzah, Amir Syahir
author_sort Mesrati, Malak Hassn
title Understanding glioblastoma biomarkers: knocking a mountain with a hammer
title_short Understanding glioblastoma biomarkers: knocking a mountain with a hammer
title_full Understanding glioblastoma biomarkers: knocking a mountain with a hammer
title_fullStr Understanding glioblastoma biomarkers: knocking a mountain with a hammer
title_full_unstemmed Understanding glioblastoma biomarkers: knocking a mountain with a hammer
title_sort understanding glioblastoma biomarkers: knocking a mountain with a hammer
publisher MDPI
publishDate 2020
url http://psasir.upm.edu.my/id/eprint/36976/1/36976.pdf
http://psasir.upm.edu.my/id/eprint/36976/
https://www.mdpi.com/2073-4409/9/5/1236
_version_ 1671341082081755136
score 13.211869

Similar Items