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Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng

Murraya koenigii (L.) (Rutaceae) is an indigenous medicinally important herb of Indian origin and now is widely distributed throughout southern Asia. The stem bark, leaves and roots of Malayan Murraya koenigii were selected for phytochemical investigation. Eight carbazole alkaloids was isolated and...

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Main Authors: Ahmad, Kartini, Tan, Siow Ping, Md. Sukari, Mohd. Aspollah, Ali, Abdul Manaf, Nafiah, Mohd Azlan
Format: Article
Language:English
Published: Scientific Research Publishing 2014
Online Access:http://psasir.upm.edu.my/id/eprint/36953/1/Cytotoxic%20and%20anti.pdf
http://psasir.upm.edu.my/id/eprint/36953/
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=49653#.VYd3jkb8bEY
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spelling my.upm.eprints.369532015-08-21T04:08:37Z http://psasir.upm.edu.my/id/eprint/36953/ Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng Ahmad, Kartini Tan, Siow Ping Md. Sukari, Mohd. Aspollah Ali, Abdul Manaf Nafiah, Mohd Azlan Murraya koenigii (L.) (Rutaceae) is an indigenous medicinally important herb of Indian origin and now is widely distributed throughout southern Asia. The stem bark, leaves and roots of Malayan Murraya koenigii were selected for phytochemical investigation. Eight carbazole alkaloids was isolated and identified using spectroscopic methods including NMR, IR, UV, MS spectra data. Crude extract and isolated compounds from the roots of this plant were screened for cytotoxic activity and antitumor promoting activity. All crude extracts of the roots including the isolated compounds, mahanimbine, mahanine and murrayafoline-A exhibited significant cytotoxic activity against CEM-SS cell line with IC50 3mg/mL. Girinimbine inhibited EBV-activation in the antitumor promoting assay. Scientific Research Publishing 2014-09 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36953/1/Cytotoxic%20and%20anti.pdf Ahmad, Kartini and Tan, Siow Ping and Md. Sukari, Mohd. Aspollah and Ali, Abdul Manaf and Nafiah, Mohd Azlan (2014) Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng. American Journal of Plant Sciences, 5 (19). pp. 2869-2877. ISSN 2158-2742; ESSN: 2158-2750 http://www.scirp.org/journal/PaperInformation.aspx?PaperID=49653#.VYd3jkb8bEY 10.4236/ajps.2014.519302
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Murraya koenigii (L.) (Rutaceae) is an indigenous medicinally important herb of Indian origin and now is widely distributed throughout southern Asia. The stem bark, leaves and roots of Malayan Murraya koenigii were selected for phytochemical investigation. Eight carbazole alkaloids was isolated and identified using spectroscopic methods including NMR, IR, UV, MS spectra data. Crude extract and isolated compounds from the roots of this plant were screened for cytotoxic activity and antitumor promoting activity. All crude extracts of the roots including the isolated compounds, mahanimbine, mahanine and murrayafoline-A exhibited significant cytotoxic activity against CEM-SS cell line with IC50 3mg/mL. Girinimbine inhibited EBV-activation in the antitumor promoting assay.
format Article
author Ahmad, Kartini
Tan, Siow Ping
Md. Sukari, Mohd. Aspollah
Ali, Abdul Manaf
Nafiah, Mohd Azlan
spellingShingle Ahmad, Kartini
Tan, Siow Ping
Md. Sukari, Mohd. Aspollah
Ali, Abdul Manaf
Nafiah, Mohd Azlan
Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng
author_facet Ahmad, Kartini
Tan, Siow Ping
Md. Sukari, Mohd. Aspollah
Ali, Abdul Manaf
Nafiah, Mohd Azlan
author_sort Ahmad, Kartini
title Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng
title_short Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng
title_full Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng
title_fullStr Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng
title_full_unstemmed Cytotoxic and anti-tumour promoting activities of carbazole alkaloids from Malayan Murraya koenigii (L.) Spreng
title_sort cytotoxic and anti-tumour promoting activities of carbazole alkaloids from malayan murraya koenigii (l.) spreng
publisher Scientific Research Publishing
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/36953/1/Cytotoxic%20and%20anti.pdf
http://psasir.upm.edu.my/id/eprint/36953/
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=49653#.VYd3jkb8bEY
_version_ 1643831876517888000
score 13.211869

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