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Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trail

Zerumbone (ZER) is a naturally occurring dietary compound, present in many natural foods consumed today. The compound derived from several plant species of the Zingiberaceae family that has been found to possess multiple biomedical properties, such as antiproliferative, antioxidant, anti-inflammator...

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Main Authors: Rahman, Heshu Sulaiman, Abdullah, Rasedee, Swee, Keong Yeap, Othman, Hemn Hassan, Chartrand, Max Stanley, Namvar, Farideh, Abdul, Ahmad Bustamam, Chee, Wun How
Format: Article
Language:English
Published: Hindawi Publishing Corporation 2014
Online Access:http://psasir.upm.edu.my/id/eprint/36662/1/Biomedical%20properties%20of%20a%20natural%20dietary%20plant%20metabolite.pdf
http://psasir.upm.edu.my/id/eprint/36662/
http://www.hindawi.com/journals/bmri/2014/920742/
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spelling my.upm.eprints.366622015-10-29T07:44:34Z http://psasir.upm.edu.my/id/eprint/36662/ Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trail Rahman, Heshu Sulaiman Abdullah, Rasedee Swee, Keong Yeap Othman, Hemn Hassan Chartrand, Max Stanley Namvar, Farideh Abdul, Ahmad Bustamam Chee, Wun How Zerumbone (ZER) is a naturally occurring dietary compound, present in many natural foods consumed today. The compound derived from several plant species of the Zingiberaceae family that has been found to possess multiple biomedical properties, such as antiproliferative, antioxidant, anti-inflammatory, and anticancer activities. However, evidence of efficacy is sparse, pointing to the need for a more systematic review for assessing scientific evidence to support therapeutic claims made for ZER and to identify future research needs. This review provides an updated overview of in vitro and in vivo investigations of ZER, its cancer chemopreventive properties, and mechanisms of action. Therapeutic effects of ZER were found to be scientifically plausible and could be explained partially by in vivo and in vitro pharmacological activities. Much of the research outlined in this paper will serve as a foundation to explain ZER anticancer bioactivity, which will open the door for the development of strategies in the treatment of malignancies using ZER. Hindawi Publishing Corporation 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36662/1/Biomedical%20properties%20of%20a%20natural%20dietary%20plant%20metabolite.pdf Rahman, Heshu Sulaiman and Abdullah, Rasedee and Swee, Keong Yeap and Othman, Hemn Hassan and Chartrand, Max Stanley and Namvar, Farideh and Abdul, Ahmad Bustamam and Chee, Wun How (2014) Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trail. BioMed Research International, 2014. art. no. 920742. pp. 1-20. ISSN 2314-6133; ESSN: 2314-6141 http://www.hindawi.com/journals/bmri/2014/920742/ 10.1155/2014/920742
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Zerumbone (ZER) is a naturally occurring dietary compound, present in many natural foods consumed today. The compound derived from several plant species of the Zingiberaceae family that has been found to possess multiple biomedical properties, such as antiproliferative, antioxidant, anti-inflammatory, and anticancer activities. However, evidence of efficacy is sparse, pointing to the need for a more systematic review for assessing scientific evidence to support therapeutic claims made for ZER and to identify future research needs. This review provides an updated overview of in vitro and in vivo investigations of ZER, its cancer chemopreventive properties, and mechanisms of action. Therapeutic effects of ZER were found to be scientifically plausible and could be explained partially by in vivo and in vitro pharmacological activities. Much of the research outlined in this paper will serve as a foundation to explain ZER anticancer bioactivity, which will open the door for the development of strategies in the treatment of malignancies using ZER.
format Article
author Rahman, Heshu Sulaiman
Abdullah, Rasedee
Swee, Keong Yeap
Othman, Hemn Hassan
Chartrand, Max Stanley
Namvar, Farideh
Abdul, Ahmad Bustamam
Chee, Wun How
spellingShingle Rahman, Heshu Sulaiman
Abdullah, Rasedee
Swee, Keong Yeap
Othman, Hemn Hassan
Chartrand, Max Stanley
Namvar, Farideh
Abdul, Ahmad Bustamam
Chee, Wun How
Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trail
author_facet Rahman, Heshu Sulaiman
Abdullah, Rasedee
Swee, Keong Yeap
Othman, Hemn Hassan
Chartrand, Max Stanley
Namvar, Farideh
Abdul, Ahmad Bustamam
Chee, Wun How
author_sort Rahman, Heshu Sulaiman
title Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trail
title_short Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trail
title_full Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trail
title_fullStr Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trail
title_full_unstemmed Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trail
title_sort biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trail
publisher Hindawi Publishing Corporation
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/36662/1/Biomedical%20properties%20of%20a%20natural%20dietary%20plant%20metabolite.pdf
http://psasir.upm.edu.my/id/eprint/36662/
http://www.hindawi.com/journals/bmri/2014/920742/
_version_ 1643831799477960704
score 13.211869

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